Effects of single or trickle Haemonchus contortus experimental infection on digestibility and host responses of naïve Creole kids reared indoor

Bambou, Jean-Christophe; Ceï, Willy; Camous, Sylvaine; Archimède, Harry; Decherf, A.; Philibert, Lucien; Barbier, Claude; Mandonnet, Nathalie; García, Eliel González

doi:10.1016/j.vetpar.2012.09.026

Cited by 15 publications

(7 citation statements)

References 28 publications

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“…The anticipated greater lean tissue growth potential and associated protein requirements of growing male lambs may also lead to greater competition for available dietary protein to meet requirements for growth and immune function in males compared to females (Houdjik et al, 2001). The decrease in PCV between measurement times that was observed in this study was consistent with results reported by Burke and Miller (2002) in Dorper and other hair sheep breeds, Bambou et al (2013) in Creole sheep, and Getachew et al (2015) in Ethiopian Menz and Washera sheep. Standard deviations indicated high variability in the Djallonké breed for both FEC and PCV, similar to that reported by Getachew et al (2015) in Ethiopian Menz and Washera lambs experimentally infected with H. contortus.…”

Section: Discussionsupporting

confidence: 85%

Resistance to gastrointestinal parasite infection in Djallonké sheep

Traoré

Notter

Soudré

et al. 2017

Animal

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Gastrointestinal parasitism places serious constraints on small ruminant production. The situation has been exacerbated by development of drug resistance in many parasite populations, leading to interest in identification of animals with genetically mediated resistance or tolerance to nematode infections. This study assessed the response to natural infection with gastrointestinal nematodes (GIN) in Djallonké sheep during the rainy season in the Sudan-Guinea Savannah region of Burkina Faso. Haemonchus contortus is the most prevalent GIN at this site and time. Djallonké lambs ( n = 434) were sampled from 40 households and evaluated at a common location in southern Burkina Faso. Lambs were dewormed with levamisole at 2 to 6 months of age and returned to infected pastures. Fecal egg counts (FEC), packed cell volumes (PCV), and FAffa Malan CHArt (FAMACHA © ) scores were determined 28 and 35 days after deworming. Lamb mortality was monitored throughout the experiment. Least-squares means for BW increased from 13.8 ± 0.2 kg at 28 days to 14.0 ± 0.2 kg at 35 days ( P < 0.01). Simple means and medians for FEC were 615 and 100, respectively, at 28 days and 850 and 175, respectively, at 35 days. The FEC exhibited strong right skewness. Following logarithmic transformation and back-transformation of resulting least-squares means to the original scale, FEC were higher ( P < 0.01) for males (208 ± 27) than females (122 ± 10). Least-squares means for PCV decreased ( P < 0.001) from 28 (36.3 ± 0.5%) to 35 days (33.7 ± 0.5%), and were higher ( P < 0.01) for females (36.0 ± 0.4%) than males (33.9 ± 0.7%). Correlations (r) between repeated measurements of BW, FEC, PCV and FAMACHA scores at 28 and 35 days were all positive ( P < 0.001). The correlation between FAMACHA scores and PCV was negative at 28 ( r = − 0.14) and 35 days ( r = − 0.18) ( P < 0.001). This study revealed that BW was an easily measured predictor of the ability of the lamb to resist infection with GIN and maintain PCV, and confirmed that FAMACHA scores are useful indicators of differences in FEC. Approximately 40% of female and 30% of male lambs did not show detectable levels of infection (i.e. FEC = 0) under field conditions. The great variability that was observed in FEC and PCV suggests potential to use Djallonké sheep in breeding programs to enhance resistance to GIN.

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Section: Discussionsupporting

confidence: 85%

Resistance to gastrointestinal parasite infection in Djallonké sheep

Traoré

Notter

Soudré

et al. 2017

Animal

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“…The gastrointestinal nematode (GIN) Haemonchus contortus is a major health problem, causing immense economic losses in goat production (Baker et al 1998 ; Bambou et al 2013 ; Campos et al 2009 ; Mandonnet et al 2001 ). In Australia, the annual losses due to GIN is estimated at over AUD 400 million (McLeod 1995 ; Sacket et al 2006 ).…”

Section: Introductionmentioning

confidence: 99%

Between-breed variations in resistance/resilience to gastrointestinal nematodes among indigenous goat breeds in Uganda

Onzima

Mukiibi

Ampaire

et al. 2017

Trop Anim Health Prod

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Gastrointestinal nematodes (GINs), Haemonchus contortus, are a major health problem in goat production. Resistance to H. contortus, the most prevalent GIN in Uganda, was studied among three indigenous goat breeds to assess their differences. Twelve male goats of each breed approximately 7 months old of small East African (SEA), Mubende, and Kigezi goats from smallholder farmers in Arua, Mubende, and Kabale were assembled for the study. At the station, they were dewormed with a combination therapy of the broad-spectrum dewormers closantel and albendazole to free the goats of gastrointestinal parasites. During experimentation, the goats were kept indoors and ad libitum fed on clean banana peels and napier grass. On attainment of zero-worm-egg status, the goats were artificially infected with 18,000 third-stage (L3) larvae of H. contortus prepared according to Baermann’s procedure. Data were collected on fecal egg count (FEC), packed cell volume (PCV), and body weight (BW) on a 2-week basis until 12 weeks post infection and carcass weight and total worm count (WC) in the abomasum at termination of the experiment. The data on FEC, PCV, and BW were subjected to repeated-measure analysis of variance and the others by one-way analysis of variance. FEC between breeds was only significantly different at 12 weeks post infection (p = 0.04). Generally, higher FEC was recorded in Kigezi compared to SEA and Mubende goats. Carcass weight was significantly different among breeds (p < 0.05), with Mubende having the highest carcass weight, followed by Kigezi and SEA. PCV and daily weight gains were significantly different between breeds (p < 0.05). WC was not significantly different between the breeds. FEC and PCV were weakly significant at later stages of the experiment with higher parasite burden suggesting potential variation in resistance to H. contortus. These differences could be exploited in designing breeding programs with disease resistance in indigenous goat breeds.

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“…It should be noted that one laboratory study of co-infection with the same rabbit helminths did not find this pattern of interaction during co-infection [ 33 ]. That laboratory study, however, used a single, high-dose infection (rather than the trickle infections we used), which can dramatically alter the form of the elicited immune response [ 57 ], in turn altering the nature of the interspecific interactions.…”

Section: Is the Observed Interaction Robust?mentioning

confidence: 99%

Predicting the effects of parasite co-infection across species boundaries

et al. 2018

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It is normal for hosts to be co-infected by parasites. Interactions among co-infecting species can have profound consequences, including changing parasite transmission dynamics, altering disease severity and confounding attempts at parasite control. Despite the importance of co-infection, there is currently no way to predict how different parasite species may interact with one another, nor the consequences of those interactions. Here, we demonstrate a method that enables such prediction by identifying two nematode parasite groups based on taxonomy and characteristics of the parasitological niche. From an understanding of the interactions between the two defined groups in one host system (wild rabbits), we predict how two different nematode species, from the same defined groups, will interact in co-infections in a different host system (sheep), and then we test this experimentally. We show that, as predicted, in co-infections, the blood-feeding nematode Haemonchus contortus suppresses aspects of the sheep immune response, thereby facilitating the establishment and/or survival of the nematode Trichostrongylus colubriformis; and that the T. colubriformis-induced immune response negatively affects H. contortus. This work is, to our knowledge, the first to use empirical data from one host system to successfully predict the specific outcome of a different co-infection in a second host species. The study therefore takes the first step in defining a practical framework for predicting interspecific parasite interactions in other animal systems.

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Effects of single or trickle Haemonchus contortus experimental infection on digestibility and host responses of naïve Creole kids reared indoor

Cited by 15 publications

References 28 publications

Resistance to gastrointestinal parasite infection in Djallonké sheep

Resistance to gastrointestinal parasite infection in Djallonké sheep

Between-breed variations in resistance/resilience to gastrointestinal nematodes among indigenous goat breeds in Uganda

Predicting the effects of parasite co-infection across species boundaries

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