Effects of single dose intranasal oxytocin on social cognition in schizophrenia

Davis, Michael C.; Lee, Jung‐Hee; Horan, William P.; Clarke, Angelika D; McGee, Mark R.; Green, Michael F.; Marder, Stephen R.

doi:10.1016/j.schres.2013.04.023

Cited by 110 publications

(96 citation statements)

References 30 publications

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“…Although these findings demonstrate the unique functional significance of social cognition, our understanding of the scope (e.g., whether automatic processes are also impaired; Lieberman, 2007), and neural correlates of these impairments in schizophrenia is limited (Brunet-Gouet et al, 2011). Guided by findings from social neuroscience, recent studies in schizophrenia have begun to extend work in this area to investigations of empathy (e.g., M. C. Davis et al, 2013;Harvey, Zaki, Lee, Ochsner, & Green, 2013;Smith et al, 2012). Empathy is a multifaceted construct that can be broadly defined as the ability to understand and share the emotional experiences of others (Decety, 2010;Iacoboni, 2009).…”

Section: Introductionmentioning

confidence: 96%

Some markers of mirroring appear intact in schizophrenia: evidence from mu suppression

Horan

Pineda

Wynn

et al. 2014

Cogn Affect Behav Neurosci

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Although schizophrenia is associated with impairments in social cognition, the scope and neural correlates of these disturbances are largely unknown. In this study, we investigated whether schizophrenia patients show impaired functioning of the mirror neuron system (MNS), as indexed by electroencephalographic (EEG) mu (8-13 Hz) suppression, a hypothesized biomarker of MNS activity that is sensitive to the degree of social interaction depicted in visual stimuli. A total of 32 outpatients and 26 healthy controls completed an EEG paradigm that included six action observation or execution conditions that differed in their degrees of social interaction. Participants also completed a validated empathy questionnaire. Across both groups, we found a significant linear increase in mu suppression across the conditions involving greater levels of social engagement and interaction, but no significant group or interaction effects. Patients self-reported diminished empathic concern and perspective taking, which showed some moderate relations to mu suppression levels. Thus, the schizophrenia group showed generally intact modulation of MNS functioning at the electrophysiological level, despite self-reporting empathic disturbances. The disturbances commonly seen on self-report, performance, and neuroimaging measures of mentalizing in schizophrenia may largely reflect difficulties with higher-level inferential processes about others' emotions, rather than a basic incapacity to share in these experiences.

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Section: Introductionmentioning

confidence: 96%

Some markers of mirroring appear intact in schizophrenia: evidence from mu suppression

Horan

Pineda

Wynn

et al. 2014

Cogn Affect Behav Neurosci

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“…Within psychotic disorders such as schizophrenia, broad cognitive deficits have been well documented [5,6,7,8], and oxytocin abnormalities may contribute to these deficits. Further, the link between social cognition and oxytocin in psychotic disorders has garnered attention due to treatment implications (e.g., intranasal oxytocin may improve facial emotion recognition) [9,10,11]. Recent evidence suggests that intranasal oxytocin may also improve general cognition in schizophrenia [12,13,14,15].…”

Section: Introductionmentioning

confidence: 99%

Oxytocin Receptor <b><i>(OXTR)</i></b> Methylation and Cognition in Psychotic Disorders

et al. 2016

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Previous reports have identified an association between cognitive impairment and genetic variation in psychotic disorders. In particular, this association may be related to abnormal regulation of genes responsible for broad cognitive functions such as the oxytocin receptor (OXTR). Within psychotic disorders, it is unknown if OXTR methylation, which can have important implications for gene regulation, is related to cognitive function. The current study examined peripheral blood OXTR methylation and general cognition in people with schizophrenia, schizoaffective disorder, and psychotic disorder not otherwise specified (N = 101). Using hierarchical multiple regression analysis, methylation at the Chr3:8767638 site was significantly associated with composite cognitive performance independent of demographic and medication factors while controlling for multiple testing in this combined diagnostic sample (adjusted p = 0.023).

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“…Across a variety of mammalian models, the administration of oxytocin enhances social recognition and bonding, and reduces anxiety associated with social threat. In schizophrenia, single-dose administration studies have shown effects of oxytocin on social cognition, including lower order facial emotion recognition (Averbeck et al, 2011;Goldman et al, 2011) and higher order social cognitive task performance (such as detection of sarcasm, deception and empathy) (Davis et al, 2013;Woolley et al, 2014). However, currently, a wide variety of tests have been used and a lack of consistency across studies, including failures to replicate (Horta de Macedo et al, 2014), has resulted in debate about the specific benefits from oxytocin treatment across different social cognitive domains in people with schizophrenia.…”

Section: Introductionmentioning

confidence: 99%

A single dose of oxytocin nasal spray improves higher-order social cognition in schizophrenia

Guastella

Ward

Hickie

et al. 2015

Schizophrenia Research

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Effects of single dose intranasal oxytocin on social cognition in schizophrenia

Cited by 110 publications

References 30 publications

Some markers of mirroring appear intact in schizophrenia: evidence from mu suppression

Some markers of mirroring appear intact in schizophrenia: evidence from mu suppression

Oxytocin Receptor <b><i>(OXTR)</i></b> Methylation and Cognition in Psychotic Disorders

A single dose of oxytocin nasal spray improves higher-order social cognition in schizophrenia

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