Effects of simultaneous docosahexaenoic acid and catechin intakes on the plasma and liver lipids in low- and high-fat diet fed mice

Shirai, Nobuyuki; Suzuki, Haruo

doi:10.1016/s0271-5317(03)00079-4

Cited by 6 publications

(7 citation statements)

References 28 publications

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“…It has also been shown that n-3 PUFA have a beneficial effect on cholesterol metabolism in mice ( , ). Previously, we reported that plasma total cholesterol and phospholipid concentrations of mice were reduced by n-3 PUFA intakes ( , ). The reduction of cholesterol levels by fish oil intake may be dependent on the inhibition of absorption and/or on the enhancement of cholesterol excretion ( , ).…”

Section: Discussionmentioning

confidence: 99%

Effects of Dietary Herring Roe Lipids on Plasma Lipid, Glucose, Insulin, and Adiponectin Concentrations in Mice

Higuchi

Shirai

Suzuki

2006

J. Agric. Food Chem.

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The aim of this study was to evaluate the effects of dietary Kazunoko (salted herring roe) lipids, which contain large amounts of cholesterol, phosphatidylcholine, and n-3 polyunsaturated fatty acids, such as eicosapentaenoic acid (EPA, 20:5n-3) and docosahexaenoic acid (DHA, 22:6n-3), on lipid and glucose metabolism in mice. Male Crlj:CD-1 (ICR) mice were fed one of four experimental diets which contained 6% lard, 1% Kazunoko lipids + 5% lard, 3% Kazunoko lipids + 3% lard, and 6% Kazunoko lipids for 12 weeks. Plasma total cholesterol, triacylglycerol, phospholipid, and glucose concentrations were significantly lower in the 3% and 6% Kazunoko lipid diet groups than in lard and 1% Kazunoko lipid diet groups (p < 0.05). Plasma adiponectin concentrations of mice fed the 6% Kazunoko lipid diet were higher than those of animals fed the lard diet group. These results suggest that EPA and DHA rather than cholesterol in the Kazunoko lipids influence the plasma total cholesterol level. The constituent Kazunoko lipids may not only decrease the levels of plasma lipids but also decrease glucose concentrations by enhancing plasma adiponectin levels in mice.

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Section: Discussionmentioning

confidence: 99%

Effects of Dietary Herring Roe Lipids on Plasma Lipid, Glucose, Insulin, and Adiponectin Concentrations in Mice

Higuchi

Shirai

Suzuki

2006

J. Agric. Food Chem.

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“…Numerous studies and clinical investigations indicate that the onset of metabolic syndrome is associated with lifestyle disorders, such as insufficient exercise, smoking, unbalanced diet, and excess drinking and eating (Firdaus, 2005;Gill and Malkova, 2006;Morriss and Mohammed, 2005;Azadbakht et al, 2005;Riccardi et al, 2004). A variety of foods, and their components, have been proposed as useful agents in the prevention of the onset of metabolic syndrome (Shirai et al, 2006c;Shirai and Suzuki, 2003;Kao et al, 2006;Borek, 2006;Murakami et al, 2005). In particular, there is evidence that intake of fish oil containing eicosapentaenoic acid (20:5n-3) and docosahexaenoic acid (22:6n-3) may help prevent CHD and diabetes (Ebbesson et al, 2005;Lombardo and Chicco, 2006;Shirai and Suzuki, 2004;Carpentier et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

A Comparative Study of Lipids Extracted from Herring Roe Products and Fish Oil on Plasma Glucose and Adipocytokine Levels in ICR Aged Mice

Shirai

Higuchi

Suzuki

2008

FSTR

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Male mice (11 months old) were fed 5% lard, fish oil, or kazunoko (salted fish roe product) lipids for 4 months to investigate the effects of diet on plasma glucose and adipocytokines. Plasma glucose levels were significantly lower in the fish oil group than in the lard group and there was a non-significant tendency towards lower levels in the kazunoko lipid group. Plasma leptin and adiponectin levels were also significantly higher in fish oil group than in lard group and resistin levels were significantly lower in the kazunoko lipid group than the lard group, but not the fish oil group. The results suggest that kazunoko lipids might be effective as a dietary component in the prevention of coronary heart disease and diabetes even though the metabolic effects of kazunoko lipids were different from those of fish oil.

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“…In this context, there is a growing interest to increase the intake of n-3 PUFA. Different strategies have been developed consisting in using food enriched in n-3 PUFA [6,7], diets supplemented with marine oils [8,9], free fatty acids (FFA) [10] or ethyl-fatty acid (FA) esters [11][12][13]. Furthermore, some studies have focussed on the difference in the chemical form of the FA esters because it may affect the absorption, distribution and metabolic fate of long-chain PUFA, especially when these are given as triglycerides (TG) or phospholipids (PL) [14][15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Early Dissimilar Fates of Liver Eicosapentaenoic Acid in Rats Fed Liposomes or Fish Oil and Gene Expression Related to Lipid Metabolism

Cansell

Battin

Degrace

et al. 2009

Lipids

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The study was undertaken to determine whether eicosapentaenoic acid (EPA, 20:5 n-3) and docosahexaenoic acid (DHA, 22:6 n-3), esterified in phospholipids (PL) as liposomes or in triglycerides (TG) as oil, exhibited comparable fates in liver lipids and whether these fates were associated with gene expressions related to fatty acid (FA) metabolism. PL and TG mixtures with close contents in EPA and DHA were administered to rats over 2 weeks. Most relevant events occurred after 3 days for both treatments. At that time, liposomes, compared with oil, increased the liver content in PL with a FA composition enriched in n-6 FA, comparable in DHA and much lower in EPA. Moreover, liposomes increased the activity and mRNA levels of carnitine palmitoyltransferase (CPT) I. In contrast, fish oil exerted opposite effects on CPT I and increased the genic expression of lipogenic enzymes. Liposomes, unlike fish oil, apparently increased the mRNA levels of acyl-CoA oxidase and the activity of the peroxisomal FA-oxidising system. Concomitantly, mRNA levels of hepatic lipoprotein receptors were increased with both diets, but intracellular proteins involved in free FA uptake and lipid synthesis were up-regulated only with liposome-treated rats. The quasi absence of EPA in hepatic PL of liposome-treated rats on the short term could result from increased beta-oxidation activities through metabolic regulations induced by more available free EPA and other PUFA.

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Effects of simultaneous docosahexaenoic acid and catechin intakes on the plasma and liver lipids in low- and high-fat diet fed mice

Cited by 6 publications

References 28 publications

Effects of Dietary Herring Roe Lipids on Plasma Lipid, Glucose, Insulin, and Adiponectin Concentrations in Mice

Effects of Dietary Herring Roe Lipids on Plasma Lipid, Glucose, Insulin, and Adiponectin Concentrations in Mice

A Comparative Study of Lipids Extracted from Herring Roe Products and Fish Oil on Plasma Glucose and Adipocytokine Levels in ICR Aged Mice

Early Dissimilar Fates of Liver Eicosapentaenoic Acid in Rats Fed Liposomes or Fish Oil and Gene Expression Related to Lipid Metabolism

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