Effects of Simulated Preparations of Plants used in Nigerian Traditional Medicine on &lt;i&gt;Candida&lt;/i&gt; spp. Associated with Vaginal Candidiasis

Ogunshe, Adenike A. O.; Lawal, Oladipupo A.; Iheakanwa, C. I.

doi:10.17348/era.6.0.373-383

Cited by 11 publications

(7 citation statements)

References 38 publications

(24 reference statements)

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“…According to Mander et al (2007: 190) among South African black population, TM "is thought to be desirable and necessary for treating a range of health problems that Western medicine does not treat adequately". In Nigeria, effective medicinal plants in management of various diseases have been documented (Aiyeola and Bello, 2006;Blench and Dendo, 2006a;2006b;Fasola, 2001;Obute, 2005;Ogunshe et al 2008;Sofowora, 1993;Weintritt, 2007) including those used for the treatment of opportunistic infections associated with HIV/AIDS (Enwereji, 2008). Weintritt (2007) identified at least 522 medicinal species used in the management of numerous ailments in Nigeria.…”

Section: Evidences Of Growing Demandmentioning

confidence: 99%

Trends and Challenges of Traditional Medicine in Africa

Abdullahi¹

2011

Afr. J. Trad. Compl. Alt. Med.

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Prior to the introduction of cosmopolitan medicine, traditional medicine used to be the dominant medical system available to millions of people in Africa in both rural and urban communities. However, the arrival of the Europeans marked a significant turning point in the history of this age-long tradition and culture. This paper examines the trends and challenges of traditional medicine in Africa. The impact of colonialism on African traditional medicine is also examined. Although the paper is on Africa, references are drawn around the world to buttress the growing demand for traditional medicine. The paper concludes that to minimise the current distrust between modern and traditional doctors and to achieve the objective of regulation, standardisation and cooperation, both traditional and modern doctors must acknowledge their areas of strengths and weaknesses from which they operate and be genuinely concerned about the difficult but necessary task of being human.

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Section: Evidences Of Growing Demandmentioning

confidence: 99%

Trends and Challenges of Traditional Medicine in Africa

Abdullahi¹

2011

Afr. J. Trad. Compl. Alt. Med.

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“…In vitro antimycotic susceptibility testing . In vitro susceptibilities / resistance to commonly available antimycotic agents in Nigeria [the imidazoles-mycoten tablets/cream, canesten tablets/cream (i.e., clotrimazoles); tetradox (doxycycline); the polyenes-mycostatine (nystatin), and the metronidazole- flagyl] were determined on SDA at 35°C after 24 and 48 hours ofincubation, using the modified method[ 18 ] of Tagg et al [ 19 ] The concentration of the inoculum suspensions of the test Candida isolates were between 1.6 and 2.4 × 10 3 cells ml -1 .…”

Section: Methodsmentioning

confidence: 99%

Clinical efficacy and health implications of inconsistency in different production batches of antimycotic drugs in a developing country

2011

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Objective:This study aimed at evaluating the in vitro efficacy and health implications of inconsistencies in different production batches of antimycotic drugs.Materials and Methods:in vitro susceptibility profiles of 36 Candida spp. – C. albicans (19.4%), C. glabrata (30.6%), C. tropicalis (33.3%), and C. pseudotropicalis (16.7%) – obtained from human endocervical and high vaginal swabs (ECS/HVS) to two different batches (B1 and B2) of six antimycotic drugs (clotrimazole, doxycycline, iconazole, itraconazole, metronidazole and nystatin) was determined using modified agar well-diffusion method.Results:None of the Candida strains had entirely the same (100%) susceptibility / resistance profiles in both batches of corresponding antimycotic drugs; while, different multiple antifungal susceptibility (MAS) rates were also recorded in batches 1 and 2 for corresponding antifungals. Only 14.3%, 27.3%, 16.7-33.3%, and 8.3-25.0% of C. albicans, C. glabrata, C. pseudotropicalis, and C. tropicalis strains, respectively, had similar susceptibility/resistance profiles toward coressponding antifungal agents in both batches; while up to 57.1% of C. albicans, 45.5% of C. glabrata, 66.7% of C. pseudotropicalis, and 50.0% of C. tropicalis strains were susceptible to one batch of antifungals but resistant to corresponding antifungals in the second batch. As high as 71.4% (C. albicans), 73.0% (C. glabrata), 50.0% (C. pseudotropicalis), and 66.74% (C. tropicalis) strains had differences of ≥ 10.0 mm among corresponding antimycotic agents.Conclusions:Candida strains exhibited different in vitro susceptibility / resistance patterns toward two batches of corresponding antimycotic agents, which has clinical implications on the efficacy of the drugs and treatment of patients. The findings of the present study will be of benefit in providing additional information in support of submission of drugs for registration to appropriate regulatory agencies.

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“…should be done. Non-azole anti-fungal drugs like Boric acid and Flucytosine can be used for non-albicans species (Ogunshe et al, 2008;Vermitsky et al, 2008;Abruquah, 2012).…”

Section: Prevalence Of Vaginal Candidiasismentioning

confidence: 99%

Advanced topical drug delivery system for the management of vaginal candidiasis

et al. 2014

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Vaginal candidiasis or vulvovaginal candidiasis (VC) is a common mucosal infection of vagina, mainly caused by Candida species. The major symptoms of VC are dyspareunia, pruritis, itching, soreness, vagina as well as vulvar erythema and edema. Most common risk factors that lead to the imbalance in the vaginal micro biota are the use of antibiotics, pregnancy, diabetes mellitus, immuno suppression as in AIDS or HIV patients, frequent sexual intercourse, spermicide and intra-uterine devices and vaginal douching. Various anti-fungal drugs are available for effective treatment of VC. Different conventional vaginal formulations (creams, gels, suppositories, powder, ointment, etc.) for VC are available today but have limited efficacy because of lesser residence time on vaginal epithelium due to self-cleansing action of vagina. So to overcome this problem, an extended and intimate contact with vaginal mucosa is desired; which can be accomplished by utilizing mucoadhesive polymers. Mucoadhesive polymers have an excellent binding capacity to mucosal tissues for considerable period of time. This unique property of these polymers significantly enhances retention time of different formulations on mucosal tissues. Currently, various novel formulations such as liposomes, nano-and microparticles, micro-emulsions, bio-adhesive gel and tablets are used to control and treat VC. In this review, we focused on current status of vaginal candidiasis, conventional and nanotechnology inspired formulation approaches.

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Effects of Simulated Preparations of Plants used in Nigerian Traditional Medicine on <i>Candida</i> spp. Associated with Vaginal Candidiasis

Cited by 11 publications

References 38 publications

Trends and Challenges of Traditional Medicine in Africa

Trends and Challenges of Traditional Medicine in Africa

Clinical efficacy and health implications of inconsistency in different production batches of antimycotic drugs in a developing country

Advanced topical drug delivery system for the management of vaginal candidiasis

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