Effects of silkworm larvae powder containing manganese superoxide dismutase on immune activity of mice

Yue, Wan‐Fu; Liu, Jianmei; Li, Guangli; Li, Xinghua; Wu, Xiyong; Sun, Jianzhong; Sun, Hongxiang; Miao, Yun‐gen

doi:10.1007/s11033-007-9116-0

Cited by 4 publications

(1 citation statement)

References 14 publications

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“…We have also investigated the effect of silkworm powder containing SOD on the antioxidation and the immune system of the mouse, focusing on hemolysin response, hemagglutination against SRBC, PFC assay and the dose-dependent increase of phagocytic activity. All treated mice showed significant enhancement of immunity (Yue et al, 2007(Yue et al, , 2008.…”

Section: Discussionmentioning

confidence: 94%

Demonstration of protein absorption in the intestinal epithelium of fish and mice by laser scanning confocal microscopy

Yue

Zhou

Malik

et al. 2010

Biological Chemistry

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Selective permeability for small proteins and oligopeptides occurs in the intestinal epithelium of many animal species and humans. Whole proteins are sometimes endocytosed and undergo partial hydrolysis in intestinal epithelial cells with the probable release of essential oligopeptides into the bloodstream. Increased permeability to certain proteins can cause asthma and other metabolic disorders. Permeable proteins have also been successfully used to deliver vaccines or drugs via oral consumption. Protein absorption has been inferred in many cases and demonstrated in some cases by histochemical, tracer, and analytical techniques. However, the nature and importance of protein absorption remains largely unknown. Here, we demonstrate the movement of two lumenal proteins (GFP: 26 kDa and OFP: 23 kDa) across the intestinal epithelium of fish and mice using laser scanning confocal microscopy. The results provide evidence that small proteins can be taken up intact by intestinal epithelial cells, even though large proteins are digested to single amino acids or protein fragments before they are absorbed. Our results suggest that it is possible to orally administer some small proteinous medicines for therapeutic purposes.

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Section: Discussionmentioning

confidence: 94%

Demonstration of protein absorption in the intestinal epithelium of fish and mice by laser scanning confocal microscopy

Yue

Zhou

Malik

et al. 2010

Biological Chemistry

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Silkworm powder containing manganese superoxide dismutase regulated the immunity and inhibited the growth of Hepatoma 22 cell in mice

Yue

Deng

et al. 2007

Mol Biol Rep

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The effects of SOD contained silkworm powder on immune regulation and inhibition against Hepatoma 22 tumor cells in vivo were investigated. The activity of natural killer cell (NK) and the ConA-stimulated spleen proliferation were measured. The results found that the SOD-contained silkworm powder caused an enhancement on NK cell activity, which implied this material modulated the immune system in mice in vivo. The NK cell activities of Hepatoma 22 tumor modeled mice treated with silkworm powder including SOD were increased significantly compared to a modeled control and silkworm powder without SOD, reaching 36.18%. In addition, the ConA-stimulated spleen proliferation of SOD treated mice was higher than that of the controls. The treatment of SOD contained silkworm powder presented 40.3% of average inhibition rate to Hepatoma 22 tumor, showing stronger inhibition against tumor. There were no significant difference in body weight between modeled control and SOD silkworm powder feeding in Hepatoma 22 tumor modeled mice, suggesting the SOD silkworm powder is safety as an inhabitant to tumor. In conclusion, these findings demonstrate that administration of silkworm powder containing SOD results in activation of NK cells and immunity, suggesting the silkworm powder containing SOD plays a positive role in tumor inhibition.

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Experimental investigation of the immunoregulatory and anti-inflammatory effects of the traditional Chinese medicine “Li-Yan Zhi-Ke Granule” for relieving chronic pharyngitis in rats

Sun

Zang

et al. 2010

Mol Biol Rep

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Chronic pharyngitis, a chronic inflammation of the pharyngeal mucous membrane and submucous lymphoid tissues, is often caused by unsatisfactory treatment of acute pharyngitis or repeated occurrences of upper respiratory tract infection and is related to a high-dust environment. Traditional herbal pharmacotherapy is well known for combining plant species to create complex phytochemical mixtures in the attempt to ameliorate pathophysiological processes. The aim of current study is to investigate the effect of immunoregulation and anti-inflammation with the traditional Chinese medicine (TCM) "Li-Yan Zhi-Ke Granule" in rats. Determination of serum hemolysin and the carbon particle clearance test were performed. The results demonstrate that administration of the TCM "Li-Yan Zhi-Ke Granule" may improve the effect of phagocytosis by mononuclear macrophages and immune function in rats, and may also increase the immunoregulatory and anti-inflammatory responses of rats with chronic pharyngitis. This traditional drug could relieve the symptoms of sore throat and cough in rats with chronic pharyngitis.

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Effects of silkworm larvae powder containing manganese superoxide dismutase on immune activity of mice

Cited by 4 publications

References 14 publications

Demonstration of protein absorption in the intestinal epithelium of fish and mice by laser scanning confocal microscopy

Demonstration of protein absorption in the intestinal epithelium of fish and mice by laser scanning confocal microscopy

Silkworm powder containing manganese superoxide dismutase regulated the immunity and inhibited the growth of Hepatoma 22 cell in mice

Experimental investigation of the immunoregulatory and anti-inflammatory effects of the traditional Chinese medicine “Li-Yan Zhi-Ke Granule” for relieving chronic pharyngitis in rats

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