Effects of Silicone Breast Implants on Human Cell Types In Vitro: A Closer Look on Host and Implant

Atiyeh, Bishara S.; Emsieh, Saif

doi:10.1007/s00266-022-02821-x

Cited by 2 publications

(4 citation statements)

References 10 publications

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“…Moreover, inflammatory reactions to silicone elastomer particulate debris [40], in specific particle shedding from breast implants [41], have been demonstrated. In particular, macrophages and foreign body giant cells (FBGCs) take up silicone [42][43][44]. Together with neutrophils, mast cells, and fibroblasts, these cells have all been implicated in sensing the biomaterial and in producing signals that may alter fibrotic responses [25,42].…”

Section: Of 37mentioning

confidence: 99%

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Quantitative Proteomic Characterization of Foreign Body Response towards Silicone Breast Implants Identifies Chronological Disease-Relevant Biomarker Dynamics

Schoberleitner¹,

Faserl²,

Sarg³

et al. 2022

Preprint

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The etiology of exaggerated fibrous capsule formation around silicone mammary implants (SMI) is multifactorial but primarily induced by immune mechanisms toward the foreign material silicone. The aim of this work was to enlighten the disease progression from implant insertion and immediate tissue damage response reflected in (a) the acute wound proteome, and (b) the adsorption of chronic inflammatory wound proteins at implant surfaces. An intra-individual absolute quantitation TMT-liquid chromatography-tandem mass spectrometry approach was applied to profile wound proteome formed around SMI the first five days post-implantation. Compared to plasma, the acute wound profile resembled a more complex composition comprising plasma-derived and locally differentially expressed proteins (DEPs). DEPs were subjected to functional enrichment analysis, which revealed the dysregulation of signaling pathways mainly involved in immediate inflammation response and ECM turnover. Moreover, we found time-course variations in protein enrichment immediately post-implantation and adsorbed to SMI surfaces after 6-8 months. Characterization of the expander-adhesive proteome by label-free approach uncovered a long-term adsorbed acute wound and the fibrosis-associated proteome. Our findings propose a wound biomarker panel for the early detection and diagnosis of excessive fibrosis that could potentially broaden insights into the characteristics of fibrotic implant encapsulation.

show abstract

Section: Of 37mentioning

confidence: 99%

“…In particular, macrophages and foreign body giant cells (FBGCs) take up silicone [42][43][44]. Together with neutrophils, mast cells, and fibroblasts, these cells have all been implicated in sensing the biomaterial and in producing signals that may alter fibrotic responses [25,42].…”

Section: Of 37mentioning

confidence: 99%

Quantitative Proteomic Characterization of Foreign Body Response towards Silicone Breast Implants Identifies Chronological Disease-Relevant Biomarker Dynamics

Schoberleitner¹,

Faserl²,

Sarg³

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Moreover, inflammatory reactions to silicone elastomer particulate debris [39]-specifically particle shedding from breast implants [40]-have been demonstrated. In particular, macrophages and foreign body giant cells (FBGCs) take up silicone [41][42][43]. Together with neutrophils, mast cells, and fibroblasts, these cells have all been implicated in sensing the biomaterial and in producing signals that may alter fibrotic responses [25,41].…”

Section: Introductionmentioning

confidence: 99%

“…In particular, macrophages and foreign body giant cells (FBGCs) take up silicone [41][42][43]. Together with neutrophils, mast cells, and fibroblasts, these cells have all been implicated in sensing the biomaterial and in producing signals that may alter fibrotic responses [25,41].…”

Section: Introductionmentioning

confidence: 99%

Quantitative Proteomic Characterization of Foreign Body Response towards Silicone Breast Implants Identifies Chronological Disease-Relevant Biomarker Dynamics

et al. 2023

View full text Add to dashboard Cite

The etiology of exaggerated fibrous capsule formation around silicone mammary implants (SMI) is multifactorial but primarily induced by immune mechanisms towards the foreign material silicone. The aim of this work was to understand the disease progression from implant insertion and immediate tissue damage response reflected in (a) the acute wound proteome and (b) the adsorption of chronic inflammatory wound proteins at implant surfaces. An intraindividual relative quantitation TMT-liquid chromatography–tandem mass spectrometry approach was applied to the profile wound proteome formed around SMI in the first five days post-implantation. Compared to plasma, the acute wound profile resembled a more complex composition comprising plasma-derived and locally differentially expressed proteins (DEPs). DEPs were subjected to a functional enrichment analysis, which revealed the dysregulation of signaling pathways mainly involved in immediate inflammation response and ECM turnover. Moreover, we found time-course variations in protein enrichment immediately post-implantation, which were adsorbed to SMI surfaces after 6–8 months. Characterization of the expander-adhesive proteome by a label-free approach uncovered a long-term adsorbed acute wound and the fibrosis-associated proteome. Our findings propose a wound biomarker panel for the early detection and diagnosis of excessive fibrosis that could potentially broaden insights into the characteristics of fibrotic implant encapsulation.

show abstract

Effects of Silicone Breast Implants on Human Cell Types In Vitro: A Closer Look on Host and Implant

Cited by 2 publications

References 10 publications

Quantitative Proteomic Characterization of Foreign Body Response towards Silicone Breast Implants Identifies Chronological Disease-Relevant Biomarker Dynamics

Quantitative Proteomic Characterization of Foreign Body Response towards Silicone Breast Implants Identifies Chronological Disease-Relevant Biomarker Dynamics

Quantitative Proteomic Characterization of Foreign Body Response towards Silicone Breast Implants Identifies Chronological Disease-Relevant Biomarker Dynamics

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