Effects of Short-Term Supplementation with Ascorbate, Folate, and Vitamins B<sub>6</sub> and B<sub>12</sub> on Inflammatory Factors and Estrogen Levels in Obese Postmenopausal Women

Palmas, Walter

doi:10.1024/0300-9831.76.1.34

Cited by 8 publications

(5 citation statements)

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“…In the Nurses' Health Study, among women with no prior history of CAD, users of multivitamins containing folate and vitamin B 6 had a reduced risk of CAD (56) . Very few human studies have been performed to evaluate the modifications of major markers of inflammation during supplementation with B vitamins, including vitamin B 6 , despite the association with either folate and/or vitamin B 12 (57,58) . Furthermore, results from these studies have shown that CRP and pro-inflammatory IL levels are unchanged after vitamin supplementation (57,58) .…”

Section: Vitamin B 6 Supplementation Inflammation and Cvd Preventionmentioning

confidence: 99%

“…Very few human studies have been performed to evaluate the modifications of major markers of inflammation during supplementation with B vitamins, including vitamin B 6 , despite the association with either folate and/or vitamin B 12 (57,58) . Furthermore, results from these studies have shown that CRP and pro-inflammatory IL levels are unchanged after vitamin supplementation (57,58) . Antioxidant activity of vitamin B 6 supplementation has been observed in a study performed on rats, but the exact mechanism is unclear (59) .…”

Section: Vitamin B 6 Supplementation Inflammation and Cvd Preventionmentioning

confidence: 99%

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Vitamin B₆: a challenging link between nutrition and inflammation in CVD

Lotto

Friso

2011

Br J Nutr

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The objective of the present review is to highlight the relationship between low vitamin B 6 status and CVD through its link with inflammation. While overt vitamin B 6 deficiency is uncommon in clinical practice, increasing evidence suggests that marginal vitamin B 6 deficiency is rather frequent in a consistent proportion of the population and is related to an increased risk of inflammation-related diseases. Ample evidence substantiates the theory of atherosclerosis as an inflammatory disease, and low plasma vitamin B 6 concentrations have been related to increased CVD risk. Several studies have also shown that low vitamin B 6 status is associated with rheumatoid arthritis and chronic inflammatory bowel diseases, both of which hold an underlying chronic inflammatory condition. Furthermore, the inverse association observed between inflammation markers and vitamin B 6 supports the notion that inflammation may represent the common link between low vitamin B 6 status and CVD risk. In addition to the epidemiological evidence, there are a number of cell culture and animal studies that have suggested several possible mechanisms relating impaired vitamin B 6 status with chronic inflammation. A mild vitamin B 6 deficiency characterises, in most cases, a subclinical at-risk condition in inflammatory-linked diseases which should be addressed by an appropriate individually tailored nutritional preventive or therapeutic strategy.

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Section: Vitamin B 6 Supplementation Inflammation and Cvd Preventionmentioning

confidence: 99%

Section: Vitamin B 6 Supplementation Inflammation and Cvd Preventionmentioning

confidence: 99%

Vitamin B₆: a challenging link between nutrition and inflammation in CVD

Lotto

Friso

2011

Br J Nutr

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“…On the basis that women have a higher Cbl level than men across age and race categories [71][72][73][74], female gender might be associated with neuroprotection and better clinical prognosis. An increment in serum estradiol caused by shortterm multi-vitamin supplementation including Cbl was reported from a study recruiting 20 postmenopausal women [75]. However, the biological interactions may vary according to exogenous or endogenous properties of sex hormone.…”

Section: Histopathologically Dwmhs But Not Pwmhsmentioning

confidence: 96%

Neurological presentations and therapeutic responses to cobalamin deficiency

Tu¹,

Lo²,

Huang³

et al. 2017

Neuropsychiatry

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BackgroundThe clinical phenotypes of cobalamin (Cbl) deficiency is often overlooked in clinical practice as their presentations vary according to the level of involvement between the hematologic and nervous systems. Although the negative impact of Cbl deficiency on cognition has been underpinned, the reported therapeutic responses after Cbl supplement therapy differ. Therefore, we aimed to describe the neurological presentations of patients with Cbl deficiency and investigate the potential biomarkers in predicting therapeutic responses with emphasis on cognitive aspects. MethodsFifty consecutive neurologically symptomatic patients with Cbl deficiency (serum level ≤ 250 pg/ml) were recruited. Serological data, baseline Mini-Mental Status Examination (MMSE) and Cognitive Abilities Screening Instrument, initial white matter hyperintensities (WMHs), and follow-up cognitive evaluations after Cbl supplementation were analyzed. Comparisons between poor (ΔMMSE < 0) and good (ΔMMSE ≥ 0) responders were performed. ResultsThe most common neurological presentations included cognitive complaints (78%), dementia (38%), anxiety (38%), and cerebrovascular disease (28%). Among the patients with cerebrovascular disease, a high prevalence of recurrence (57.1%) and related major intracranial artery occlusion (35.7%) were noted. Of the 30 patients with follow-up cognitive evaluations, benefits on short-term memory and verbal fluency (both p < 0.05) were noted. Among the good responders, benefits in total MMSE and short-term memory scores were significant (both p < 0.05). The good responders had higher serum folate levels than the poor responders (p < 0.05; Cohen's d = 1.044). The poor responders had a greater total WMH load and deep white matter hyperintensities (DWMHs) [both p < 0.05; Hedges' g of total WMHs = 0.8429; Hedges' g of DWMHs = 0.8890]. ConclusionsAlthough Cbl supplement therapy had positive and domain-specific benefits on cognition, the therapeutic responses were modulated by serum folate levels and initial WMH load. A serum folate level between 16.8 and 24.6 ng/mL had a synergistic benefit on cognition during Neuropsychiatry (London) (2017) 7(3) 186Research Min-Chien Tu and 2.00 µmol/l had neurological improvements after Cbl therapy [11]. In addition, limited studies have stressed the importance of evaluating both cognition and structural brain imaging in patients with a low Cbl status [8,14]. Taken together, changes in cognition related to replacement therapy may be affected by preexisting and relevant brain parenchymal damage. Therefore, in this study we aimed to (i) describe the various neuropsychiatric presentations before and after Cbl supplement treatment, and (ii) elucidate factors predicting therapeutic responses among patients with Cbl deficiency. Materials and Methods Subjects and clinical registryThis study recruited 50 consecutive symptomatic patients with Cbl deficiency (≤ 250 pg/mL) [15], who visited the Department of Neurology of our hospital from March 2012 to March 2015. The initial neurological disease...

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“…With prenatal vitamins being recommended to women, and vitamin enrichment in a vast majority of processed foods, it can become all too easy to get into ranges of exposure to vitamins that may impact estrogen levels. Obese post-menopausal women experienced increases in serum E2 in response to supplementation with vitamins C, B6, B12 and folic acid [185]. Folic acid [102,103] and B12 [129] increase tissue response to estrogens.…”

Section: Environmental Endocrine Disruptorsmentioning

confidence: 99%

Pathogenicity of Endocrine Dysregulation in Autism: The Role of the Melanin-Concentrating Hormone System

Swierczynski¹

2019

SciMed. J.

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The voluminous daily output of autism research has become increasingly disconnected, existing largely within highly specific subspecialty areas, and lacking cross-disciplinary linkages of context, theory, and findings to inform a unified body of knowledge. Robust syntheses of published research across the fields of psychiatry, cellular and molecular biology, neurology, endocrinology, immunology, behavioral and social sciences, and pedagogy may help clarify and extend current knowledge by guiding more efficient future research efforts investigating underlying causes, developmental divergences, novel treatments, and specific, sensitive biological markers in autism. This synthesis of interdisciplinary research indicates the hypothalamic-pituitary-adrenal (HPA) stress axis may be at the center of an interaction among sex steroids, immune function, signaling protein transcriptions, neurogenesis, and dysregulation of brain structures sending or receiving projections from the HPA stress axis. These interactions manifest observably as a range of sexually dimorphic behaviors and functional limitations often falling within the current diagnostic features of Autism Spectrum Disorder (ASD). The pathogenicity of endocrine dysregulation may serve as a valuable model for developing a cohesive theory of ASD by explaining how the HPA and connected brain areas respond to extreme conditions of dysregulated endocrine signaling to cause symptoms associated with autism.

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Effects of Short-Term Supplementation with Ascorbate, Folate, and Vitamins B₆ and B₁₂ on Inflammatory Factors and Estrogen Levels in Obese Postmenopausal Women

Cited by 8 publications

References 0 publications

Vitamin B₆: a challenging link between nutrition and inflammation in CVD

Vitamin B₆: a challenging link between nutrition and inflammation in CVD

Neurological presentations and therapeutic responses to cobalamin deficiency

Pathogenicity of Endocrine Dysregulation in Autism: The Role of the Melanin-Concentrating Hormone System

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Effects of Short-Term Supplementation with Ascorbate, Folate, and Vitamins B6 and B12 on Inflammatory Factors and Estrogen Levels in Obese Postmenopausal Women

Cited by 8 publications

References 0 publications

Vitamin B6: a challenging link between nutrition and inflammation in CVD

Vitamin B6: a challenging link between nutrition and inflammation in CVD

Neurological presentations and therapeutic responses to cobalamin deficiency

Pathogenicity of Endocrine Dysregulation in Autism: The Role of the Melanin-Concentrating Hormone System

Contact Info

Product

Resources

About

Effects of Short-Term Supplementation with Ascorbate, Folate, and Vitamins B₆ and B₁₂ on Inflammatory Factors and Estrogen Levels in Obese Postmenopausal Women

Vitamin B₆: a challenging link between nutrition and inflammation in CVD

Vitamin B₆: a challenging link between nutrition and inflammation in CVD