Effects of Short and Medium Term use of Artesunate on Fertility in Male Rats

Jewo, PI; Fadeyibi, IP; Saalu, LC; Amole, O.O.; Izegbu, MC; Ashiru, Oladapo A.

doi:10.4314/njhbs.v7i2.11670

Cited by 2 publications

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“…ART causes embryo-fetal toxicity causing embryo deaths and malformations [10,11]. Toxicity reports on rats indicate that under certain conditions, ART suppresses spermatogenesis in testis [12]. Therefore, it is essential to evaluate the effect of ART on spermatogenesis and sperm DNA integrity.…”

Section: Introductionmentioning

confidence: 98%

The antimalarial agent artesunate causes sperm DNA damage and hepatic antioxidant defense in mice

Singh

Giri

2015

Mutation Research/Genetic Toxicology and Environmental Mutagene

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Section: Introductionmentioning

confidence: 98%

The antimalarial agent artesunate causes sperm DNA damage and hepatic antioxidant defense in mice

Singh

Giri

2015

Mutation Research/Genetic Toxicology and Environmental Mutagene

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“…Recent studies suggest that artesunate could cause some histometrical changes in the rat testes by the sloughing of the germinal epithelium from the basement membrane and reduction in the population of the germ cells. These changes were apparently dose dependent ( Jewo et al 2008 ; Izunya et al 2010 ).…”

Section: Introductionmentioning

confidence: 99%

Ameliorative Effects of Curcumin on Artesunate-Induced Subchronic Toxicity in Testis of Swiss Albino Male Mice

et al. 2015

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India is one of the endemic areas where control of malaria has become a formidable task. Artesunate is the current antimalarial drug used to treat malaria, especially chloroquine resistant. The objective of the present study was to investigate the dose-dependent effect of oral administration of artesunate on the oxidative parameters in testes of adult male Swiss albino mice and ameliorative efficacy of curcumin, a widely used antioxidant. An oral dose of 150 mg/kg body weight (bwt; low dose) and 300 mg/kg bwt (high dose) of artesunate was administered for a period of 45 days to male mice, and ameliorative efficacy of curcumin was also assessed. The results revealed that artesunate caused significant alteration in oxidative parameters in dose-dependent manner. Administration of artesunate brought about significant decrease in activities of superoxide dismutase, glutathione, glutathione peroxidase, and glutathione reductase, whereas lipid peroxidation and glutathione-S-transferase activity were found to be significantly increased. The results obtained show that oxidative insult is incurred upon the intracellular antioxidant system of testis tissue by artesunate treatment. Further, administration of curcumin at the dose level of 80 mg/kg bwt along with both doses of artesunate attenuated adverse effects in male mice.

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Effects of Short and Medium Term use of Artesunate on Fertility in Male Rats

Cited by 2 publications

References 0 publications

The antimalarial agent artesunate causes sperm DNA damage and hepatic antioxidant defense in mice

The antimalarial agent artesunate causes sperm DNA damage and hepatic antioxidant defense in mice

Ameliorative Effects of Curcumin on Artesunate-Induced Subchronic Toxicity in Testis of Swiss Albino Male Mice

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