Effects of ShenLing BaiZhu San Supplementation on Gut Microbiota and Oxidative Stress in Rats with Ulcerative Colitis

Gu, Daxing; Zhou, Shanshan; Yao, Lili; Tan, Ying; Chi, Xingzi; Shi, Dayou; Guo, Shining; Liu, Cui

doi:10.1155/2021/3960989

Cited by 9 publications

(5 citation statements)

References 44 publications

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“…One study evaluated the effects of SLBZP on gut microbiota and antioxidation in a rat model of ulcerative colitis (UC). This study aimed to understand how SLBZP supplementation could influence gut health and oxidative stress in inflammatory bowel conditions ( Gu et al, 2021 ). SLBZP has been demonstrated to exert protective effects against non-alcoholic fatty liver disease (NAFLD).…”

Section: Discussionmentioning

confidence: 99%

Network pharmacology and gut microbiota insights: unraveling Shenling Baizhu powder’s role in psoriasis treatment

Tang,

Zheng,

Luo

et al. 2024

Front. Pharmacol.

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Background: Psoriasis, a chronic skin condition characterized by systemic inflammation and altered gut microbiota, has been a target of Traditional Chinese Medicine (TCM) for centuries. Shenling Baizhu Powder (SLBZP), a TCM formulation, holds promise for treating inflammatory diseases, but its specific role in psoriasis and impact on gut microbiota is not fully understood.Objective: This study aims to elucidate the mechanism of SLBZP in treating psoriasis, integrating component analysis, network pharmacology, and experimental validation in mice models.Methods: We commenced with a detailed component analysis of SLBZP using liquid chromatograph and mass spectrometer (LC-MS). Network pharmacology analysis was used to predict the potential action targets and pathways of SLBZP in psoriasis. An in vivo experiment was conducted with psoriasis mice models, treated with SLBZP. Therapeutic effects were assessed via symptomatology, histopathology, and immunohistochemical analysis. Gut microbiota composition was analyzed using 16S rRNA gene sequencing.Results: A total of 42 main components and quality markers were identified, primarily from licorice and ginseng, including flavonoids, saponins and other markers. PPI topology analysis showed that TNF, IL-6, IL-1β, TP53 and JUN were the core DEPs. 168 signaling pathways including lipid and atherosclerosis, AGE-RAGE signaling pathway, IL-17 signaling pathway and Th17 cell differentiation were enriched by KEGG. SLBZP demonstrated significant therapeutic effects on psoriasis in mice, with alterations in skin pathology and biomarkers. Additionally, notable changes in gut microbiota composition were observed post-treatment, indicating a possible gut-skin axis involvement.Conclusion: This research has pinpointed lipid metabolism as a key pathway in the treatment of psoriasis with SLBZP. It explores how SLBZP’s modulation of gut microbiota and lipid metabolism can alleviate psoriasis, suggesting that balancing gut microbiota may reduce inflammation mediators and offer therapeutic benefits. This underscores lipid metabolism modulation as a potential new strategy in psoriasis treatment.

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Section: Discussionmentioning

confidence: 99%

Network pharmacology and gut microbiota insights: unraveling Shenling Baizhu powder’s role in psoriasis treatment

Tang,

Zheng,

Luo

et al. 2024

Front. Pharmacol.

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“…Zhang et al [ 54 ] found that fecal microbiota transplantation increased the relative abundance of Firmicutes , reduced the abundance of Bacteroidetes , and restored the intestinal microbiota to normal levels. The study found that Shenlingbaizhusan increases the relative abundance of SCFA-producing bacteria at the genus level, including Oscillospira [ 55 ]. In this study, the abundance of Osmospirillum spp.…”

Section: Discussionmentioning

confidence: 99%

Trans-Anethole Alleviates DSS-Induced Ulcerative Colitis by Remodeling the Intestinal Flora to Regulate Immunity and Bile Acid Metabolism

Li,

Liu,

2023

Mediators of Inflammation

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Ulcerative colitis (UC) is the most common inflammatory bowel disease (IBD); it is incurable, and the treatment is expensive. Trans-anethole (TA), the main component of fennel, exhibits various biological activities. An increasing number of studies have demonstrated the efficacy of herbal active ingredients in the treatment of UC. This study aimed to investigate the effect and mechanism of TA in UC. In this study, we have experimented on mice with dextran sulfate sodium salt (DSS)-induced UC. The TA group was gavaged with 62.5 mg/kg TA by gavage once daily on days 8–14. To observe the effect of TA on the colon tissue, various investigations were performed, including western blot and immunohistochemistry for intestinal barrier protein expression, TUNEL staining for apoptosis, western blot, and ELISA for inflammation level, flow cytometry for Th17/Treg, LC–MS for blood bile acid content, GC–MS for blood fatty acid content, and 16s RNA for intestinal contents. TA alleviated weight loss in mice with UC; increased colon length; alleviated intestinal mucosal damage; upregulated claudin-1, occludin, and ZO-1 protein expression levels; reduced inflammatory factors in the colon and serum; and alleviated apoptosis. TA reduced fatty acid and bile acid levels by inhibiting colony abundance and reducing Th17/Treg cell differentiation in the colon. We found that TA alleviates DSS-induced UC by remodeling the intestinal flora to regulate immunity and bile acid metabolism.

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“…Shenling Baizhu powder has the potential to enhance the prevalence of the SCFA-producing bacteria Puccinia and Treponema and decrease the prevalence of the opportunistic pathogens Vibrio desulfuricans and Cholera spp. It significantly reduces the level of myeloperoxidase, increases the levels of catalase and SOD in the serum of rats, and exerts antimicrobial effects by enhancing the antioxidant capacity and modulating the intestinal microbiota ( Gu et al, 2021 ).…”

Section: Therapeutic Intervention For Amd With Tcmmentioning

confidence: 99%

Role of traditional Chinese medicine in age-related macular degeneration: exploring the gut microbiota’s influence

Yu,

Liu,

Meng

2024

Front. Pharmacol.

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The pathogenesis of age-related macular degeneration (AMD), a degenerative retinopathy, remains unclear. Administration of anti-vascular endothelial growth factor agents, antioxidants, fundus lasers, photodynamic therapy, and transpupillary warming has proven effective in alleviating symptoms; however, these interventions cannot prevent or reverse AMD. Increasing evidence suggests that AMD risk is linked to changes in the composition, abundance, and diversity of the gut microbiota (GM). Activation of multiple signaling pathways by GM metabolites, including lipopolysaccharides, oxysterols, short-chain fatty acids (SCFAs), and bile acids (BAs), influences retinal physiology. Traditional Chinese medicine (TCM), known for its multi-component and multi-target advantages, can help treat AMD by altering GM composition and regulating the levels of certain substances, such as lipopolysaccharides, reducing oxysterols, and increasing SCFA and BA contents. This review explores the correlation between GM and AMD and interventions for the two to provide new perspectives on treating AMD with TCM.

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Effects of ShenLing BaiZhu San Supplementation on Gut Microbiota and Oxidative Stress in Rats with Ulcerative Colitis

Cited by 9 publications

References 44 publications

Network pharmacology and gut microbiota insights: unraveling Shenling Baizhu powder’s role in psoriasis treatment

Network pharmacology and gut microbiota insights: unraveling Shenling Baizhu powder’s role in psoriasis treatment

Trans-Anethole Alleviates DSS-Induced Ulcerative Colitis by Remodeling the Intestinal Flora to Regulate Immunity and Bile Acid Metabolism

Role of traditional Chinese medicine in age-related macular degeneration: exploring the gut microbiota’s influence

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