Effects of sex, height and age on motor evoked potentials with magnetic stimulation

Tobimatsu, Shozó; Sun, Shu-Jian; Fukui, Roh; Kato, Motohiro

doi:10.1007/s004150050215

Cited by 50 publications

(32 citation statements)

References 24 publications

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“…7,36,43 In healthy subjects, significant correlations between CMCT in the lower limbs and height also have been reported. 3,4,8,9,12,41 Age also correlates with JOA score in patients with CCM. 10,24,27,28 Therefore, the partial correlation coefficient (r') was analyzed after adjusting for age and height.…”

Section: Discussionmentioning

confidence: 97%

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Electrophysiological assessments of the motor pathway in diabetic patients with compressive cervical myelopathy

Nakanishi¹,

Tanaka²,

Kamei³

et al. 2015

SPI

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OBJECT The occurrence of compressive cervical myelopathy (CCM) increases in adults over 50 years of age. In addition, diabetes mellitus (DM) is a frequent comorbidity for people of this age and may impact the severity of CCM. The authors assessed motor pathway function in diabetic patients with CCM to investigate the correlation between electrophysiological parameters and clinical symptoms. METHODS Motor evoked potentials (MEPs) were measured from the abductor digiti minimi muscle (ADM) and the abductor hallucis muscle (AH) following transcranial magnetic stimulation, as were M- and F-waves following electrical stimulation of the ulnar and tibial nerves, in 22 patients with CCM and diabetes mellitus (DM) who had not experienced symptomatic diabetic neuropathy (CCM-DM group), in 92 patients with CCM alone (CCM group), and in 24 healthy adults (control group). The peripheral conduction time (PCT; measured from the ADM and AH) was calculated as follows: (M-wave latency + F-wave latency −1)/2. The central motor conduction time (CMCT; measured from the ADM and AH) was calculated by subtracting the PCT from the onset latency of the MEPs. The Japanese Orthopaedic Association (JOA) score for cervical myelopathy was obtained before and 1 year after surgery as a clinical outcome measure. RESULTS MEP, PCT, and CMCT parameters in the CCM-DM and CCM groups were significantly longer than those in the control group (p = 0.000−0.007). The PCTs in the CCM-DM group were significantly longer than those in the CCM group (p = 0.001−0.003). No significant differences were detected in the MEP and CMCT parameters between the CCM-DM and CCM groups (p = 0.080–1.000). The JOA score before surgery in the CCM-DM group was 10.7 ± 2.0 points and was significantly lower than that in the CCM group (12.2 ± 2.5 points, p = 0.015). In the CCM-DM group, JOA scores before surgery correlated with MEP-AH (r = −0.610, p = 0.012) and PCT-AH (r = −0.676, p = 0.004) values, but not with CMCT values, while the JOA scores were related to both MEP and CMCT parameters in the CCM group. The JOA scores improved to 13.8 ± 2.2 points after surgery (p = 0.001) and correlated with MEP-AH (r = −0.667, p = 0.005) and PCT-AH (r = −0.611, p = 0.012) in the CCM-DM group. CONCLUSIONS The results suggest that MEP, PCT, and CMCT parameters each reveal abnormalities in the upper and lower motor neurons even in patients with DM. The results also show a prolonged PCT in CCM-DM patients, despite having no history of diabetic neuropathy. Corticospinal tract impairments are similar between CCM and CCM-DM patients, while the JOA score of the CCM-DM patients is lower than that in the CCM patients. The JOA score in CCM-DM patients may be influenced by additional impairments in peripheral nerves or other diabetic complications. These electrophysiological studies may be useful for screening motor pathway function for CCM in patients with DM.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 97%

Electrophysiological assessments of the motor pathway in diabetic patients with compressive cervical myelopathy

Nakanishi¹,

Tanaka²,

Kamei³

et al. 2015

SPI

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“…The corticospinal tracts to the two striated sphincters should be of comparable length, i.e., to the urethral sphincter perhaps even a bit longer due to the curved route of the perineal branch of the pudendal nerve. That we studied an exclusively female group could in part explain the di¡erence: both male sex and height are independently and positively correlated to cortical latencies [Tobimatsu et al, 1998]. It should also be noted that we carefully selected our group of healthy controls among nonpatients and rigorously excluded those with possible confounding conditions.…”

Section: Discussionmentioning

confidence: 99%

Motor evoked potentials from the striated urethral sphincter and puborectal muscle: Normative values

Brostrøm

Jennum

Lose

2003

Neurourology and Urodynamics

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“…Factors such as age, sex, and height should be considered when comparing results of groups.We found an e¡ect of height on latencies; our data was not suited to an assessment of the e¡ect of age or sex. Age and sex have been shown by others to a¡ect results of conduction studies of limb innervation [Tobimatsu et al, 1998]. Interestingly, shorter latencies have been observed in women, and this e¡ect of female sex seems to be independent of height.…”

Section: Sources Of Variabilitymentioning

confidence: 94%

Motor evoked potentials from the pelvic floor

Brostrøm

2003

Neurourology and Urodynamics

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Effects of sex, height and age on motor evoked potentials with magnetic stimulation

Cited by 50 publications

References 24 publications

Electrophysiological assessments of the motor pathway in diabetic patients with compressive cervical myelopathy

Electrophysiological assessments of the motor pathway in diabetic patients with compressive cervical myelopathy

Motor evoked potentials from the striated urethral sphincter and puborectal muscle: Normative values

Motor evoked potentials from the pelvic floor

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