Effects of Sevoflurane on Cytokine Balance in Patients Undergoing Coronary Artery Bypass Graft Surgery

Kawamura, Takae; Kadosaki, Mamoru; Nara, Noriko; Kaise, Atsushi; Suzuki, Hirotaka; Endo, S; Wei, Jicheng; Inada, Katsuya

doi:10.1053/j.jvca.2006.01.011

Cited by 53 publications

(38 citation statements)

References 30 publications

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“…us, it has become increasingly evident that both circulating and tissue concentrations of cytokines play important roles in surgery outcome and should be well controlled. Kawamura and Corcoran [23,24] both studied the e ects of sevo urane and propofol on cytokine balance in patients undergoing surgery. ey found that sevo urane and propofol suppressed the production of IL-6 and IL-8, and a change in the balance between pro-and antiin ammatory cytokines may be one of the most important mechanisms of anesthetic-induced tissue protection.…”

Section: Discussionmentioning

confidence: 99%

Low-dose ketamine pretreatment reduces oxidative damage and inflammatory response following CO2 pneumoperitoneum in rats

Xu¹,

Gào²,

Peng³

et al. 2014

CIM

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Low-dose ketamine pretreatment reduces oxidative damage and in ammatory response following CO2 pneumoperitoneum in rats AbstractPurpose: e duration of pneumoperitoneum during laparoscopic procedures may contribute to post-surgical oxidative stress. Previous studies have shown that low-dose ketamine, an anesthetic with anti-in ammatory properties, protects various organs from ischemia-reperfusion injury. is study investigated the e ects of low-dose ketamine on the overproduction of oxidants and the tissue damage caused by intra-abdominal pressure during CO2 pneumoperitoneum.Methods: Male Sprague Dawley rats received a CO2 pneumoperitoneum of 15 mmHg and preceded by either low-dose ketamine (KP1, 5 mg/kg; KP2, 10 mg/kg) or 0.9% saline (PR, 3 ml). General anethesia was provided by pentobarbital and sevo urane. e control group (CR) received an intraperitoneal saline injection and sham surgery. ree hours a er pneumoperitoneum, serum concentrations of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), malondialdehyde (MDA), superoxide dismutase (SOD) and intestinal fatty acid binding protein (iFABP) were measured and liver, kidney, lung, and intestine were evaluated for tissue damage.Results: e highest plasma MDA, TNF-α, IL-6 and iFABP values were observed at T1 (a er 3 hours of pneumoperitoneum) in the PR group, followed by the KP1, KP2, and CR groups (P < 0.01). SOD concentrations showed an opposite trend and were highest in the CR group, followed by the KP2, KP1, and PR groups (P < 0.01). TNF-α concentration was signi cantly lower in the KP2 than the KP1 group (P < 0.05). Histopathologic scoring of organ sections demonstrated the lowest scores in the KP2 group, followed by the KP1 and PR groups, in an increasing order (P < 0.05).Conclusion: Pretreatment with low-dose ketamine before general anaesthesia protects against potential oxidative damage and in ammatory response caused by CO2 pneumoperitoneum.

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Section: Discussionmentioning

confidence: 99%

Low-dose ketamine pretreatment reduces oxidative damage and inflammatory response following CO2 pneumoperitoneum in rats

Xu¹,

Gào²,

Peng³

et al. 2014

CIM

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“…In the setting of on-pump coronary artery bypass grafting (CABG) supplementation of cardioplegia solution with sevoflurane inhibits CD11b up-regulation as well as the release of IL-6 and TNF-α [5]. Another study in patients undergoing on-pump CABG found a sevoflurane-associated modification of the balance between pro-and anti-inflammatory mediators [6].…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, it has been reported that sevoflurane may have the potential to inhibit pro-inflammatory events in the setting of cardiac surgery [6]. Nevertheless, it is unclear whether routine administration of sevoflurane On this background, the aim of our study was to investigate whether sevoflurane administration may modulate the ECC-triggered inflammatory response during ex vivo ECC.…”

Section: Introductionmentioning

confidence: 99%

The volatile anesthetic sevoflurane inhibits activation of neutrophil granulocytes during simulated extracorporeal circulation

Schmid

Krajewski

Bachmann

et al. 2012

International Immunopharmacology

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“…channels, and ROS are related to the signal transduction of APC [15][16][17][18][19]. Furthermore, myocardial protection by sevoflurane could also be related to its anti-inflammatory effect [20].…”

Section: Discussionmentioning

confidence: 99%

Sevoflurane and nitrous oxide exert cardioprotective effects against hypoxia-reoxygenation injury in the isolated rat heart

et al. 2009

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It is unclear whether nitrous oxide (N(2)O) has a protective effect on cardiac function in vitro. In addition, little is known about the cardioprotective effect of anesthesia administered during hypoxia or ischemia. We therefore studied the cardioprotective effects of N(2)O and sevoflurane administered before or during hypoxia in isolated rat hearts. Rat hearts were excised and perfused using the Langendorff technique. For hypoxia-reoxygenation, hearts were made hypoxic (95% N(2), 5% CO(2)) for 45 min and then reoxygenated (95% O(2), 5% CO(2)) for 40 min (control: CT group). Preconditioning was achieved through three cycles of application of 4% sevoflurane (sevo-pre group) or 50% N(2)O (N(2)O-pre group) for 5 min with 5-min washouts in between. Hypoxic conditions were achieved by administering the 4% sevoflurane (sevo-hypo group) or 50% N(2)O (N(2)O-hypo group) during the 45-min hypoxic period. L-type calcium channel currents (I(Ca,L)) were recorded on rabbit myocytes. (1) Both 4% sevoflurane and 50% N(2)O significantly reduced left ventricular developed pressure (LVDP). Sevoflurane also increased left ventricular end-diastolic pressure, though N(2)O did not. (2) The recoveries of LVDP and pressure-rate product (PRP) after hypoxia-reoxygenation were better in the sevo-pre group than in the CT or N(2)O-pre group. (3) Application of either sevoflurane or N(2)O during hypoxia improved recovery of LVDP and PRP, and GOT release was significantly lower than in the CT group. (4) Sevoflurane and N(2)O reduced I(Ca,L) to similar extents. Although sevoflurane administered before or during hypoxia exerts a cardioprotective effect, while N(2)O shows a cardioprotective effect only when administered during hypoxia.

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Effects of Sevoflurane on Cytokine Balance in Patients Undergoing Coronary Artery Bypass Graft Surgery

Cited by 53 publications

References 30 publications

Low-dose ketamine pretreatment reduces oxidative damage and inflammatory response following CO2 pneumoperitoneum in rats

Low-dose ketamine pretreatment reduces oxidative damage and inflammatory response following CO2 pneumoperitoneum in rats

The volatile anesthetic sevoflurane inhibits activation of neutrophil granulocytes during simulated extracorporeal circulation

Sevoflurane and nitrous oxide exert cardioprotective effects against hypoxia-reoxygenation injury in the isolated rat heart

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