Effects of Sevoflurane, Isoflurane and Propofol Infusions on Post-Operative Recovery Criteria in Geriatric Patients

Abstract

We compared the effects of sevoflurane, isoflurane and propofol infusions on postoperative recovery criteria in geriatric patients. Sixty patients aged > 65 years, classified as American Society of Anesthesiologists (ASA) group 1 or 2 and undergoing gynaecological or urological procedures were randomized equally into three groups. Group 1 received 1 minimum alveolar concentration (MAC) sevoflurane in a 50% O 2 /N 2 O mixture and group 2 received 1 MAC isoflurane in a 50% O 2 /N 2 O mixture. Group 3 received a 50% O 2 /N 2 O mixture plus propofol total intravenous anaesthesia (8 mg/kg for the first 30 min, followed by 6 mg/kg for maintenance). Recovery criteria comprising the times to spontaneous eye opening, extubation, response to verbal stimuli and orientation were recorded following the discontinuation of anaesthesia. Recovery times were significantly shorter in groups 1 and 3 compared with group 2. We conclude that sevoflurane and propofol had similar effects on recovery criteria and were associated with a faster recovery than isoflurane.

Comparative evaluation of cost effectiveness and recovery profile between propofol and sevoflurane in laparoscopic cholecystectomy

“…found no difference between sevoflurane and propofol as regards to extubation time and other emergence characteristics. [ 13 ] The selection of geriatric patients as an inclusion characteristic could have blunted any difference between the two groups in this study.…”

Janus Kinase Mediates Faster Recovery From Sevoflurane Anesthesia Than Isoflurane Anesthesia in the Migratory Locusts

“…In this study, the anesthesia recovery assay showed that the recovery duration of locusts with sevoflurane anesthesia was shorter than those with isoflurane anesthesia (Mann–Whitney U = 214, P < 0.01) ( Figure 3B ), about 37 percent of isoflurane-anesthetized locusts did not recover within 10 min after discontinuing anesthesia, and the proportion of the unrecovered locusts was significantly higher in isoflurane anesthesia than those in sevoflurane anesthesia ( G = 14.06, P < 0.01) ( Figure 3C ). Thus, conforming to anesthesia recovery of sevoflurane and isoflurane in fruit flies and in clinical operations ( Peduto et al, 1998 ; Arar et al, 2005 ; Olufs et al, 2018 ), the migratory locusts show shorter recovery duration in sevoflurane anesthesia than in isoflurane anesthesia.…”

“…Although nearly 50 percent of this insect were anesthetized in 30 min of isoflurane exposure (1.2%) or 30 min of sevoflurane exposure (3.2%) ( Figure 3A ), they did not show obvious phenotype differences during exposure to isoflurane and sevoflurane. Considering that recovery is faster in sevoflurane anesthesia than in isoflurane anesthesia in fruit flies and in clinical practice ( Peduto et al, 1998 ; Arar et al, 2005 ; Olufs et al, 2018 ), we intended to explore phenotypic differences during the recovery from isoflurane and sevoflurane anesthesia.…”

“…In clinical practice, sevoflurane anesthesia has a clinical advantage of maintaining stable hemodynamics and rapid recovery ( Chen et al, 1998 ). In obese and geriatric patients, sevoflurane shows a faster recovery and greater respiratory safety as compared with isoflurane ( Golembiewski, 2004 ; Gupta et al, 2004 ; Arar et al, 2005 ). In neurosurgery and prolonged open urological surgery, sevoflurane provides faster emergence than that of isoflurane ( Peduto et al, 1998 ; Gauthier et al, 2002 ).…”

Perbandingan Skor Ramsay Anestetika Inhalasi Isofulran Dibanding Sevofluran Pada Pasien Pasca Operasi Abdomen

“…Dimana secara farmakologis, sevofluran lebih unggul dalam hal induksi dan eliminasi dari jaringan bila dibandingkan dengan isofluran. 6,10 Pemulihan dari anestesi umum tergantung pada sejumlah faktor termasuk durasi anestesi, fisika-kimia dari agen anestesi (kelarutan dan protein pengikat), dan tingkat metabolisme dan/atau ekskresi. Lamanya anestesi dan kelarutan anestesi dalam darah merupakan penentu utama dari durasi efek anestesi untuk agen inhalasi.…”