Effects of sevoflurane and propofol anesthesia on intraoperative endothelial cell function in patients undergoing laparoscopic cholecystectomy

Abstract

Objectives To investigate the effects of sevoflurane and propofol anesthesia on inflammatory or anti-inflammatory responses in patients undergoing laparoscopic cholecystectomy (LC). Methods Patients undergoing LC (n = 23) were divided into sevoflurane (S) (n = 11) and propofol (P) (n = 12) anesthesia groups. A blood sample was taken before induction (T0), after induction but before pneumoperitoneum (T1), 15 minutes after pneumoperitoneum (T2), immediately after extubation (T3), and 30 minutes after extubation (T4). P-selectin-positive platelets and intercellular cell adhesion molecule-1 (ICAM-1)-positive lymphocytes, and plasma P-selectin, ICAM-1 and thrombomodulin (TM) levels were analyzed. Results Sevoflurane significantly increased P-selectin expression in platelets at T2, T3, and T4 and in plasma at T1, T2, T3, and T4, but it did not affect ICAM-1 and TM. Propofol had no significant effects on P-selectin, ICAM-1, and TM expression during anesthesia and surgery. P-selectin, ICAM-1, and TM expression was higher in the S compared with P group at T1, T2, and T3 for platelet P-selectin; T2 and T4 for plasma P-selectin; T1 and T2 for lymphocyte ICAM-1; and T1, T2, and T3 for plasma TM. Conclusions Propofol anesthesia can delay the inflammatory reactions during laparoscopic surgery and better maintain the structure stability and function in vascular endothelial cells.

Peripheral inflammation as a potential mechanism and preventive strategy for perioperative neurocognitive disorder under general anesthesia and surgery

“…Endothelial cells, located within blood vessels, play a crucial role in maintaining normal vascular function and preventing inflammatory responses ( Figarola et al, 2014 ). Research indicates that propofol can reduce endothelial cell inflammatory reactions and damage, helping to preserve normal vascular function ( Fan et al, 2020 ).…”

Propofol ameliorates renal ischemia/reperfusion injury by enhancing macrophage M2 polarization through PPARγ/STAT3 signaling

“…Propofol (Pro), an intravenous anesthetic, is generally used for the sedation of surgical patients [14,15]. Remarkably, Pro administration has shown to attenuate organ I/R injury and improve surgical outcomes in clinical and preclinical settings [11,[16][17][18].…”

Sevoflurane alleviates lung injury and inflammatory response compared with propofol in a rat model of VV ECMO

“…6 Furthermore, increasing evidence has shown that sevoflurane and propofol have antiinflammatory effects. [7][8][9][10] ARDS refers to an acute inflammatory response associated with diffuse lung infiltrates resulting in a systemic inflammatory response syndrome (SIRS). 11 Apart from lung disease, VV ECMO is also initiated in instances of rapid and complex inflammatory response, similar to that seen in SIRS.…”