Effects of sevoflurane and enflurane on lower esophageal sphincter pressure and gastroesophageal pressure gradient in children

Kohjitani, Atsushi; Shirakawa, Junji; E, Satoh; Kagawa, Tetsuro; Nakajima, Masayori; Obara, Hidefumi

doi:10.1007/s005400050013

Cited by 12 publications

(2 citation statements)

References 25 publications

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“…When combined with 66% nitrous oxide, both sevoflurane and enflurane cause a small reduction in esophageal barrier pressure in children. 9 In adult humans, nitrous oxide administered alone or in combination with halothane or enflurane causes a decrease in GESP of 64%, 25%, and 28%, respectively. 10 In dogs, administration of isoflurane and halothane are associated with some reduction in GESP and barrier pressure is reduced by 21%.…”

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confidence: 99%

Influence of halothane, isoflurane, and sevoflurane on gastroesophageal reflux during anesthesia in dogs

Wilson¹,

Boruta²,

Evans³

2006

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mentioning

confidence: 99%

Influence of halothane, isoflurane, and sevoflurane on gastroesophageal reflux during anesthesia in dogs

Wilson¹,

Boruta²,

Evans³

2006

ajvr

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“…12 The authors questioned the role that propofol, NPO status, endoscopy with air insufflation, decreased oral intake and decreased activity played in these differences. There is some literature on the effects of propofol on LES pressures; 13 however, no correlation to reflux has been made. Previous studies on the effects of anesthesia on GER are very limited and are mainly in the veterinary literature.…”

Section: Discussionmentioning

confidence: 99%

Effects of Anesthesia on Pediatric pH Impedance

Hurtado

Sheiko²,

Gralla³

et al. 2016

J. pediatr. gastroenterol. nutr.

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Objectives Anesthesia can alter gastric and small intestinal motility, but its effect on gastroesophageal reflux (GER) is unclear. We set out to evaluate the effect of anesthesia on pH-multichannel intraluminal Impedance (pH Impedance) evaluation of GER. Methods Retrospective single center analysis of 95 pH Impedance probe studies performed in patients both with anesthesia exposure and esophagogastroduodenoscopy (n=50) and without (n=45). Results Increased acid reflux per hour, non-acid reflux per hour and total reflux per hour was observed in the first 4 hours, both overall and in ≥1 year olds and in both sedation groups. This difference remained for the older children without sedation by multiple regression analysis for non-acid reflux per hour and total reflux per hour. Patients using PPI had more non-acid reflux events per hour and total reflux events per hour regardless of sedation. Conclusions Based on the results of this study, there is no need to eliminate the data collected immediately after placement of the probe in children under 1 year old, but in those ≥1 without sedation, there may be a greater number of reflux events in the first 4 hours. The first 4 hours, therefore, should be carefully evaluated in patients older than 1 year of age. Further study is needed to provide normative data for the first 4 hours versus the later time period, both for those undergoing sedation as well as unsedated patients, in order to validate the findings from this study and to better understand the mechanism of GER.

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Anesthetic management of a child with Aicardi syndrome undergoing laparoscopic Nissen’s fundoplication: a case report

et al. 2010

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Aicardi syndrome (AS) is a rare congenital syndrome and is characterized by the triad of infantile spasm, agenesis of the corpus callosum, and anomaly of chorioretinal lacunae. We here report a case of a patient with AS under general anesthesia. Although there is no report in which muscle relaxants were used in AS patients, vecuronium bromide was used for artificial pneumoperitoneum in this case. Careful management is important for AS patients during an operation that significantly affects respiratory function. In addition, it is possible that muscle relaxants be administered safely in AS patients. Careful monitoring such as epileptiform electroencephalogram and bispectral index monitors may be needed for the early detection of epileptic activities.

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Effects of sevoflurane and enflurane on lower esophageal sphincter pressure and gastroesophageal pressure gradient in children

Abstract: Sevoflurane and enflurane have an inhibitory effect on LES smooth muscle in anesthetized children. However, since the reduction was relatively low, even at high concentrations, these inhalation anesthetics are unlikely to influence gastroesophageal reflux during anesthesia.

Cited by 12 publications

References 25 publications

Influence of halothane, isoflurane, and sevoflurane on gastroesophageal reflux during anesthesia in dogs

Influence of halothane, isoflurane, and sevoflurane on gastroesophageal reflux during anesthesia in dogs

Effects of Anesthesia on Pediatric pH Impedance

Anesthetic management of a child with Aicardi syndrome undergoing laparoscopic Nissen’s fundoplication: a case report

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