Effects of Sevoflurane Administered Using a Low Flow System on the Liver and Kidney

Yasuda, Norio; Mishina, J.; Miyano, Kazuko; Tanifuji, Yasumasa; Amaki, Yoshikiyo; Kobayashi, K

doi:10.1097/00000542-199109001-00345

Cited by 3 publications

(5 citation statements)

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“…Similar findings were obtained in another study using even lower gas flows (350 ml min 91 ) in association with soda lime, in which 17 patients received an average of 2.3 MAC-h of sevoflurane [88]. The mean concentration of compound A was found to be 6 ppm, and the highest recorded value was 22 ppm [88]. After more prolonged exposure, the mean maximum concentration of compound A was 7.6<1.0 ppm, with the highest individual value of 14.1 ppm occurring after 5 h exposure to sevoflurane at a flow of 5 litre min 91 [40].…”

Section: Interaction With Carbon Dioxide Absorbantssupporting

confidence: 85%

“…Concentrations of compound A increased progressively over the first 4 h of anaesthesia and then declined with continuing exposure to sevoflurane [29]. Similar findings were obtained in another study using even lower gas flows (350 ml min 91 ) in association with soda lime, in which 17 patients received an average of 2.3 MAC-h of sevoflurane [88]. The mean concentration of compound A was found to be 6 ppm, and the highest recorded value was 22 ppm [88].…”

Section: Interaction With Carbon Dioxide Absorbantssupporting

confidence: 65%

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Sevoflurane-a long-awaited volatile anaesthetic

Smith¹,

Nathanson²,

White³

1996

British Journal of Anaesthesia

138

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History of sevoflurane Research to develop a safe, non-inflammable inhaled anaesthetic agent began in the 1930s when chemists discovered that the substitution of fluorine for other halogens "lowers the boiling point, increases stability, and generally decreases toxicity" [5]. This work was continued by McBee, who used his knowledge of fluorine chemistry gained from working on the "Manhattan" atomic bomb project, to investigate a number of fluorine-containing compounds, none of which was eventually suitable for clinical use. In 1951, Suckling synthesized halothane, and soon the search for other clinically useful fluorine-containing anaesthetics began in earnest.

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Section: Interaction With Carbon Dioxide Absorbantssupporting

confidence: 85%

Section: Interaction With Carbon Dioxide Absorbantssupporting

confidence: 65%

Sevoflurane-a long-awaited volatile anaesthetic

Smith¹,

Nathanson²,

White³

1996

British Journal of Anaesthesia

138

View full text Add to dashboard Cite

show abstract

“…In contrast, no significant difference in com-pound A production was observed during sevoflurane anesthesia at a gas flow rate of 2 vs. 0.5 L/min with a circle system (207). At low flow rates, no significant changes in BUN, creatinine, or liver enzymes were observed (140,332).…”

Section: Renal Effectsmentioning

confidence: 95%

“…At low flow rates, no significant changes in BUN, creatinine, or liver enzymes were observed (140,332).…”

Section: Renal Effectsmentioning

confidence: 99%

“…Initially, it was demonstrated that sevoflurane in the presence of the carbon dioxide absorbers, soda lime (calcium, sodium, and potassium hydroxide mixture), or Baralyme ® (barium, sodium, calcium, and potassium hydroxide mixture) degrades to compound A and compound B (186,332). Sevoflurane degradation occurs within the anesthesia machine from the extraction of an acidic proton (from an inhalational anesthetic) by a strong base (soda lime or Baralyme ® ) to form compound A (186).…”

Section: Renal Effectsmentioning

confidence: 99%

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Sevoflurane: Approaching the Ideal Inhalational Anesthetic A Pharmacologic, Pharmacoeconomic, and Clinical Review

2001

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Sevoflurane is a safe and versatile inhalational anesthetic compared with currently available agents. Sevoflurane is useful in adults and children for both induction and maintenance of anesthesia in inpatient and outpatient surgery. Of all currently used anesthetics, the physical, pharmacodynamic, and pharmacokinetic properties of sevoflurane come closest to that of the ideal anesthetic (200). These characteristics include inherent stability, low flammability, non-pungent odor, lack of irritation to airway passages, low blood:gas solubility allowing rapid induction of and emergence from anesthesia, minimal cardiovascular and respiratory side effects, minimal end-organ effects, minimal effect on cerebral blood flow, low reactivity with other drugs, and a vapor pressure and boiling point that enables delivery using standard vaporization techniques. As a result, sevoflurane has become one of the most widely used agents in its class.

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