Effects of several exorphins and endorphins on the escape reaction of the cockroach Periplaneta americana under elevated temperature conditions

Грицай, О.Б.; Дубынин, В. А.; Bespalova, Zh. D.; Pilipenko, V. E.

doi:10.1134/s0022093009040057

Cited by 5 publications

(7 citation statements)

References 18 publications

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“…Under the influence of FN, rodents underwent an increase in the total distance traveled by them, number of stays, moves to the center, and number of searches in holes, which indicates a reduction of anxiety [9]. The effects revealed by us are consistent with our previous studies of the impact of opioid peptides on the development of protective behavior in insects [11,12]. Despite different effects of behavioral reactions in cockroaches and rats, which appear in stressful situations, FN in both cases had an anxiolytic effect.…”

Section: Discussionsupporting

confidence: 92%

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Effects of N-terminal nociceptin fragment on the anxiety level of American cockroach Periplaneta americana in the “open field” during changes in light intensity

Грицай

Дубынин

2015

Moscow Univ. Biol.Sci. Bull.

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Injection of N terminal nociceptin fragment (FN) had an anxiolytic effect on the anxiety level of the cockroach Periplaneta americana during the "open field" test in both red light and varying light. The intensity of horizontal activity (HA) and number of changes in direction (CD) by insects were taken as an indicator of their anxiety level. FN decreased HA in red light to 48% (100 µg/g) and 63% (200 µg/g) with CD of 39% (100 µg/g) relative to control. Tetrapeptide at a dose of 50 µg/g had no significant effect on HA and CD. With the light stimulus increased to 6.0 W, HA and CD reached 230% and 192%, respectively, relative to control. In this case, FN injection inhibited further HA increase in bright light to 37% (100 µg/g) and 50% (200 µg/g). CD also reduced to 39% (100 µg/g) and 68% (200 µg/g) relative to control.

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Section: Discussionsupporting

confidence: 92%

“…In order to study the effect of N terminal nocicep tin fragment (FN) on the anxiety level of P. americana, we used the method of "open field" [10][11][12]. The apparatus used was a glass cylinder (diameter 30 cm, height 10 cm), whose bottom was divided into sectors.…”

Section: Methodsmentioning

confidence: 99%

Effects of N-terminal nociceptin fragment on the anxiety level of American cockroach Periplaneta americana in the “open field” during changes in light intensity

Грицай

Дубынин

2015

Moscow Univ. Biol.Sci. Bull.

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“…One Conundrum though is that no genes encoding for opioid-like peptides of receptors have been found in the Drosophila genome (Kreienkamp et al, 2002). Yet, Opioid-like substances are known to have “anti-nociception”-like effects and to modulate the threshold for escape in insects (Stefano et al, 1990; Gritsai et al, 2000; Gritsai et al, 2009). In our laboratory, we have shown that opioid agonists led to an increased nocifensive startle threshold in cockroaches (Gavra and Libersat, 2011).…”

Section: Discussionmentioning

confidence: 99%

“…For example, Drosophila larvae and adults produce a stereotyped defensive behavior in response to noxious mechanical, chemical or thermal stimuli (Tracey et al, 2003; Xu et al, 2006; Fiala, 2008; Neely et al, 2011; Im and Galko, 2012; Honjo et al, 2016; Tokusumi et al, 2017; Hu et al, 2018). This type of behavior is also evoked in cockroaches in response to thermal noxious stimuli (Gritsai et al, 2004; Gritsai et al, 2009; Maliszewska et al, 2018). With this mind, the present paper has examined the nociceptive pathway from sensory reception to motor behavior in the cockroach Periplaneta americana using primarily electrophysiological recordings.…”

Section: Introductionmentioning

confidence: 93%

Nociceptive Pathway in the Cockroach Periplaneta americana

Emanuel

Libersat

2019

Front. Physiol.

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Detecting and avoiding environmental threats such as those with a potential for injury is of crucial importance for an animal’s survival. In this work, we examine the nociceptive pathway in an insect, the cockroach Periplaneta americana , from detection of noxious stimuli to nocifensive behavior. We show that noxious stimuli applied to the cuticle of cockroaches evoke responses in sensory axons that are distinct from tactile sensory axons in the sensory afferent nerve. We also reveal differences in the evoked response of post-synaptic projection interneurons in the nerve cord to tactile versus noxious stimuli. Noxious stimuli are encoded in the cockroach nerve cord by fibers of diameter different from that of tactile and wind sensitive fibers with a slower conduction velocity of 2–3 m/s. Furthermore, recording from the neck-connectives show that the nociceptive information reaches the head ganglia. Removing the head ganglia results in a drastic decrease in the nocifensive response indicating that the head ganglia and the nerve cord are both involved in processing noxious stimuli.

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“…Thus, rubiscolin might be the first opioid ligand to appear on the earth, and it may have existed in plants much earlier than the appearance of its receptor in the animal kingdom. Rubiscolin is reported to suppress the escape reaction of cockroaches [63].…”

Section: A) Leaf Proteinmentioning

confidence: 99%

Bioactive peptides derived from natural proteins with respect to diversity of their receptors and physiological effects

Yoshikawa

2015

Peptides

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We have found various bioactive peptides derived from animal and plant proteins, which interact with receptors for endogenous bioactive peptides such as opioids, neurotensin, complements C3a and C5a, oxytocin, and formyl peptides etc. Among them, rubiscolin, a δ opioid peptide derived from plant RuBisCO, showed memory-consolidating, anxiolytic-like, and food intake-modulating effects. Soymorphin, a μ opioid peptide derived from β-conglycinin showed anxiolytic-like, anorexigenic, hypoglycemic, and hypotriglyceridemic effects. β-Lactotensin derived from β-lactoglobulin, the first natural ligand for the NTS2 receptor, showed memory-consolidating, anxiolytic-like, and hypocholesterolemic effects. Weak agonist peptides for the complements C3a and C5a receptors were released from many proteins and exerted various central effects. Peptides showing anxiolytic-like antihypertensive and anti-alopecia effects via different types of receptors such as OT, FPR and AT2 were also obtained. Based on these study, new functions and post-receptor mechanisms of receptor commom to endogenous and exogenous bioactive peptides have been clarified.

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Effects of several exorphins and endorphins on the escape reaction of the cockroach Periplaneta americana under elevated temperature conditions

Cited by 5 publications

References 18 publications

Effects of N-terminal nociceptin fragment on the anxiety level of American cockroach Periplaneta americana in the “open field” during changes in light intensity

Effects of N-terminal nociceptin fragment on the anxiety level of American cockroach Periplaneta americana in the “open field” during changes in light intensity

Nociceptive Pathway in the Cockroach Periplaneta americana

Bioactive peptides derived from natural proteins with respect to diversity of their receptors and physiological effects

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