Effects of sertraline on depressive symptoms and attentional and executive functions in major depression

Constant, Éric; Adam, Stéphane; Gillain, B.; Serón, Xavier; Bruyer, Raymond; Seghers, Arlette

doi:10.1002/da.20060

Cited by 71 publications

(44 citation statements)

References 45 publications

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“…In addition to mood, the serotonergic system has also been implicated in other symptoms associated with PMDD, including food cravings (Rapkin, 1992;Dye & Blundell, 1997) and cognitive deficits (e.g. Chamberlain et al, 2006;Constant et al, 2005). For example, in women with premenstrual complaints, serotonergic stimulation improved memory deficits (Schmitt et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Changes in mood, cognitive performance and appetite in the late luteal and follicular phases of the menstrual cycle in women with and without PMDD (premenstrual dysphoric disorder)

Reed

Levin

Evans

2008

Hormones and Behavior

134

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Although it's been reported that women with premenstrual dysphoric disorder (PMDD) have increased negative mood, appetite (food cravings and food intake), alcohol intake and cognitive deficits premenstrually, few studies have examined these changes concurrently within the same group of women or compared to women without PMDD. Thus, to date, there is not a clear understanding of the full range of PMDD symptoms. The present study concurrently assessed mood and performance tasks in 29 normally cycling women (14 women who met DSM-IV criteria for PMDD and 15 women without PMDD). Women had a total of ten sessions: two practice sessions, 4 sessions during the follicular phase and 4 sessions during the late luteal phase of the menstrual cycle. Each session, participants completed mood and food-related questionnaires, a motor coordination task, performed various cognitive tasks and ate lunch. There was a significant increase in dysphoric mood during the luteal phase in women with PMDD compared to their follicular phase and compared to Control women. Further, during the luteal phase, women with PMDD showed impaired performance on the Immediate and Delayed Word Recall Task, the Immediate and Delayed Digit Recall Task and the Digit Symbol Substitution Test compared to Control women. Women with PMDD, but not Control women, also showed increased desire for food items high in fat during the luteal phase compared to the follicular phase and correspondingly, women with PMDD consumed more calories during the luteal phase (mostly derived from fat) compared to the follicular phase. In summary, women with PMDD experience dysphoric mood, a greater desire and actual intake of certain foods and show impaired cognitive performance during the luteal phase. An altered serotonergic system in women with PMDD may be the underlying mechanism for the observed symptoms; correspondingly, treatment with specific serotonin reuptake inhibitors (SSRIs) remains the preferred treatment at this time.

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Section: Discussionmentioning

confidence: 99%

Changes in mood, cognitive performance and appetite in the late luteal and follicular phases of the menstrual cycle in women with and without PMDD (premenstrual dysphoric disorder)

Reed

Levin

Evans

2008

Hormones and Behavior

134

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“…Although cognitive impairment does not correlate with actual severity of depressive psychopathology [4,15] , there is evidence that cognitive functions, specifically attentional and executive functions, can improve during antidepressant treatment [22,23] . Further, the question arises as to whether there is an association between cognitive impairment at baseline and treatment outcome.…”

Section: Introductionmentioning

confidence: 99%

Improved Alertness Is Associated with Early Increase in Serum Brain-Derived Neurotrophic Factor and Antidepressant Treatment Outcome in Major Depression

Mikoteit¹,

Hemmeter²,

Brand³

et al. 2015

Neuropsychobiology

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Background/Aims: In major depression cognitive impairment is common and may persist despite improvement in psychopathology. So far it is unclear how closely related improvement in cognitive functioning is to the clinical course of depression. Further, it is unclear whether recovery from cognitive impairment is linked to changes in serum brain-derived neurotrophic factor (sBDNF). The objectives of this study were (1) to explore the predictive value of cognitive impairment for therapeutic outcome, and (2) to assess the association between cognitive performance and sBDNF levels over a 6-week course of antidepressant treatment. Methods: Twenty-five adult patients suffering from major depression underwent standardized treatment with duloxetine. Both severity of depression as assessed by the Hamilton Depression Rating Scale and sBDNF levels were measured at baseline, and after 1, 2 and 6 weeks of treatment. Cognitive performance, i.e. alertness, working memory, and divided attention, was assessed at baseline, after 1 week, and at the end of treatment after 6 weeks. Results: Higher performance in alertness and divided attention at baseline correlated with less severe depression at week 6. During the first week of treatment, a greater increase in sBDNF was associated with a greater improvement in alertness at week 6. Conclusion: Greater alertness at baseline was a predictor of favorable antidepressive treatment outcome. Moreover, the early increase in sBDNF correlated with improvement in attention functioning. Thus, recovery from cognitive impairment and an early increase in sBDNF seem to be associated.

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“…Furthermore, they are less able to correctly identify the words that they do recall; research suggests that this could be the result of encoding deficits in addition to strategy deficits (Channon, Baker, & Robertson, 1993;Channon & Green, 1999). Interference control deficits have also been observed in depressed individuals (Constant et al, 2005;Markela-Lerenc, Kaiser, & Fiedler, 2006), as has impaired response inhibition when completing tasks including word-nonword pairs (Channon & Green, 1999;Stordal et al, 2004). Decreased performance on set shifting tasks has been suggested by some research, although findings are still discrepant at this point (Kyte, Goodyer, & Sahakian, 2005;Stordal et al, 2004).…”

Section: Executive Functionmentioning

confidence: 90%

Interpersonal Violence, Depression, and Executive Function

Hebenstreit

DePrince

Chu

2014

Journal of Aggression, Maltreatment & Trauma

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This study considers links between the number of types of violence to which women have been exposed, depression, and executive functions (EFs). Substantial research has established EF deficits among depressed individuals as well as individuals exposed to trauma. Studies have also indicated a relationship between trauma exposure and depressive symptoms across a range of traumatic events, such as combat exposure, motor vehicle accidents, natural disasters, and assaults. This study examines this relationship in an ethnically diverse community sample of 93 women exposed to interpersonal violence who completed a battery of EF tasks that assessed processing speed, working memory, response inhibition, and set shifting. Women reported an average of 5.8 types of interpersonal violence events. The number of types of interpersonal violence events was significantly related to depressive symptoms, although not EF performance. Specific EFs, such as working memory and response inhibition, were positively related to depressive symptoms. KEYWORDS adult survivor, exposure to violence, females, traumaOver the past several decades, an expanding body of epidemiological and clinical research has established that individuals exposed to potentially traumatic events have substantially higher lifetime rates of depression than do individuals who have not been exposed to potentially traumatic events

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Effects of sertraline on depressive symptoms and attentional and executive functions in major depression

Cited by 71 publications

References 45 publications

Changes in mood, cognitive performance and appetite in the late luteal and follicular phases of the menstrual cycle in women with and without PMDD (premenstrual dysphoric disorder)

Changes in mood, cognitive performance and appetite in the late luteal and follicular phases of the menstrual cycle in women with and without PMDD (premenstrual dysphoric disorder)

Improved Alertness Is Associated with Early Increase in Serum Brain-Derived Neurotrophic Factor and Antidepressant Treatment Outcome in Major Depression

Interpersonal Violence, Depression, and Executive Function

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