Effects of sertraline on autonomic and cognitive functions in healthy volunteers

Abstract

Cognitive and psychomotor performance are not altered in healthy humans receiving multiple dosing with sertraline. The observed decreases in heart rate and SCL may be due to a sympatho-inhibitory effect of sertraline.

Effect of medication and psychotherapy on heart rate variability in panic disorder

“…Siepmann et al [53] investigated the effects of sertraline on autonomic and cognitive function in a randomized, placebo controlled, crossover study. They gave 12 healthy male volunteers 50 mg of sertraline and placebo, each for 14 days (with a 14-day washout period in between).…”

Effects of Fluoxetine and Venlafaxine on the Salivary Gland - Experimental Study

“…The flow reduction could occur through the serotonin receptor action presented at the peripheric microcirculation (Hunter & Wilson, 1995;Siepmann et al, 2003). According to Schubert & Izutsu (1987), the salivary flow can be affected by drugs through alteration of the blood flow to the salivary glands.…”

“…This leads to the introduction of a heterogeneous group of compounds (to which venlafaxine belongs), the atypical antidepressants. In practice, the most recent drugs may definitively be superior to the tricyclic drugs in terms of side effects and acute toxicity, but they have not been shown to have a faster action or be more effective (Goldstein & Goodnick, 1998;Siepmann et al, 2003).…”

Verbal memory performance during subchronic challenge with a selective serotonergic and a mixed action antidepressant

“…A few studies in healthy volunteers have been conducted to assess the effects of SSRIs on memory specifically but these studies have shown controversial results. Subchronic administration of sertraline produced no effects on memory compared to placebo (Schmitt et al, 2001;Siepmann et al, 2003) but subchronic administration of paroxetine did impair delayed recall on a memory task (Schmitt et al, 2001). An acute dose of the SSRI fluvoxamine, 50 and 100 mg, produced no effect on memory compared to placebo (Fairweather et al, 1996).…”