Effects of SertaSil on wound healing in the rat

Bilyayeva, O. O.; Нешта, В. В.; Golub, A. A.; Sams-Dodd, Frank

doi:10.12968/jowc.2014.23.8.410

Cited by 5 publications

(3 citation statements)

References 5 publications

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“…This disarmament of both offensive and defensive weaponry returns control to the immune system. This was confirmed in a preclinical wound healing model (24), where MPPT, compared to the topical antibiotic gentamicin, led to a 107% (2.1fold) increase in the overall number of immune cells in the wound, including a 24.8-fold increase in the number of macrophages and a 7.2-fold increase in lymphocytes (23,24). The level of immune cells in the gentamicin group was similar to untreated controls.…”

Section: Introductionmentioning

confidence: 78%

Stable closure of acute and chronic wounds and pressure ulcers and control of draining fistulas from osteomyelitis in persons with spinal cord injuries: non-interventional study of MPPT passive immunotherapy delivered via telemedicine in community care

Sams-Dodd,

Belci,

Bandi

et al. 2024

Front. Med.

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BackgroundMicropore particle technology (MPPT) is a topical wound treatment. It is a passive immunotherapy, acting via the skin and wound microbiome without the use of antimicrobial action. In a general patient population, it removed wound infections 60% and initiated tissue regeneration 50% quicker than antibiotics and antiseptics. As MPPT supports the immune system, the aim was to confirm that MPPT is also effective in immunocompromised individuals. People with spinal cord injury (SCI) are immunodeficient due to their injury and not an underlying disease and recruit 50% fewer immune cells to an injury. The study, therefore, determined the efficacy, safety, health economics, and sustainability of MPPT in acute and chronic wounds and pressure ulcers in this patient population.MethodsPressure ulcers in SCI persons are an orphan indication, patient variability is high, and ICH E10 excludes comparators due to ethical concerns. The study design was, therefore, a single-arm, non-interventional, observational, post-market surveillance study of MPPT for treating wounds and pressure ulcers and removing soft tissue infection in connection with draining fistulas in SCI persons. The study was based on telemedicine in community care.ResultsThe study included 44 wounds. All acute and chronic grade 1–4 wounds and pressure ulcers reached stable closure. In wounds acting as fistulas draining from an underlying, primary focus of infection, e.g., osteomyelitis, MPPT removed the soft tissue infection in approx. 2.5 months and supported regeneration, considerably reducing fistula sizes. Compared to standard care, per-wound cost savings were 51 to 94% depending on wound grade and age, and substantial nursing resources were freed up. The telemedicine approach was well received by participants and supported independence and self-care. The use of antimicrobials, plastics, and synthetic polymers was essentially eliminated. MPPT did not require bed rest.ConclusionThe study confirmed that MPPT is safe and effective in treating acute and chronic wounds in immunocompetent and immunocompromised individuals, including wounds with antimicrobial-resistant infections. MPPT also removes soft tissue infections caused by an underlying primary focus of infection, such as osteomyelitis. Non-healing wounds currently represent an unmet clinical need. The findings suggest that a therapy acting via the microbiome without antimicrobial actions is effective.

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Section: Introductionmentioning

confidence: 78%

Stable closure of acute and chronic wounds and pressure ulcers and control of draining fistulas from osteomyelitis in persons with spinal cord injuries: non-interventional study of MPPT passive immunotherapy delivered via telemedicine in community care

Sams-Dodd,

Belci,

Bandi

et al. 2024

Front. Med.

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“…Attention was payed to the standardization of wounds received, the size of which did not exceed 400 mm2. After 4-5 days, necrotomy of the affected area was performed and then treatment of wounds was begun until healing [2].Our previous studies found that rapid wound healing of various etiologies using melaninin occurred in the initial phase of the regeneration of the skin. Herein, analysis of active contraction of the wound surface in dynamics was evident on days 3, 5, 7, 9, 14, 21 and on the 30 th day.…”

Section: Matherials and Methodsmentioning

confidence: 99%

Tlr2, Tjp1 genes expression during wound healing dynamics – with melanin treatment

Dranitsina

Dvorshchenko

Taburets

et al. 2017

Current Issues in Pharmacy and Medical Sciences

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Wound healing is the complex and dynamic process of replacing devitalized and missing cellular structures and tissue layers. We have previously shown that melanin, herein, produced by the Antarctic black yeast fungi Pseudonadsoniella brunea (Nadsoniella nigra sp. X-1), has expressed a cyto-protective effect, promoted rapid wound healing of various ethiology and can be offered as a new dermatropic drug. The current study was conducted on a rat model of purulent necrotic wound. In each model, one group was a control, while in the others, wound healing occurred without drug application or with administration of 0,5% carbopol or with both 0,5% carbopol and 0,1% melanin. The pro-oxidant-antioxidant balance in skin gomogenate in dynamics on 3, 6, 9, 14 and day of full epithelization was estimated using the spectrophotometric biochemical method. Moreover, so as to understand the role played by the Tlr2 and Tjp1 in the process of wound healing and scar formation, Tlr2, Tjp1gene expression and genetic mRNA was determined with quantitative RT-PCR. The application of our pharmacological composition stimulated the decrease of Tlr2 and Tjp1 gene expression against the background of suppression of free radical processes (reduction of superoxide anion radical content) with epithelization and without scarring. The results of this study have shown the positive effects of melanin on wound healing. The obtained results indicate the advisability of applying melanin for the treatment of inflammatory processes.

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“…Розмір ран не пови-нен перевищувати 400 мм 2 . На 4-5-ту добу здійснювали некротомію уражених ділянок і починали лікування ран до повного загоєння [16]. Для визначення відсотка вологи у тка-нині зразки шкіри зважували на аналітичних вагах і висушували до постійної маси при 80°С у сушильній шафі СНОЛ 3,5.3.5.3.5./И1 (Росія).…”

Section: методикаunclassified

Influence of Melanine on Morphofunctional Indices of Rat Skin With Chemical Burner and Full-Thickness Wound

Taburets¹,

Vereschaka²,

Beregova³

et al. 2017

Fiziol Zh

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Effects of SertaSil on wound healing in the rat

Abstract: The study found that SertaSil reduced the time to reaching a clean wound by 60% compared to Gentaxane and promoted faster wound closure and better recovery. These findings suggest that SertaSil may be valuable for use in the treatment of wounds in patients.

Cited by 5 publications

References 5 publications

Stable closure of acute and chronic wounds and pressure ulcers and control of draining fistulas from osteomyelitis in persons with spinal cord injuries: non-interventional study of MPPT passive immunotherapy delivered via telemedicine in community care

Stable closure of acute and chronic wounds and pressure ulcers and control of draining fistulas from osteomyelitis in persons with spinal cord injuries: non-interventional study of MPPT passive immunotherapy delivered via telemedicine in community care

Tlr2, Tjp1 genes expression during wound healing dynamics – with melanin treatment

Influence of Melanine on Morphofunctional Indices of Rat Skin With Chemical Burner and Full-Thickness Wound

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