Effects of serotonin1/2 receptor agonists on dark-phase food and water intake in rats

Agonist diversity in 5-HT2C receptor-mediated weight control in rats

“…5-HT 2A receptor activation is reported to show hypophagia (Aulakh et al 1994) and 5-HT 2B receptor activation is reported to increase or decrease food intake (Kennett et al 1997;Schreiber et al 2000). However, the involvement of other receptors in this hypophagic effect is less likely, since our result in antagonist study and many previous studies suggest that the 5-HT 2C receptor is the main receptor mediating the hypophagic effect of YM348, RO60-0175, and mCPP (Tecott et al 1995;Clifton et al 2000;Hayashi et al 2004).…”

5‐HT2 receptors in Drosophila are expressed in the brain and modulate aspects of circadian behaviors

“…In view of the high expression of 5-HT 2 Dro receptor in subesophageal gustatory neurons, one avenue that bears further exploration is the possibility that the flies are not eating enough, and are slowly starving to death. The 5-HT 2 agonist DOI has been shown by others to produce hypophagia in rodents (Aulakh et al, 1994;Schreiber et al, 2000). Furthermore, ketanserin, while having no effect on food intake itself, blocks DOI induced hypophagia and restores normal feeding in rodents (Aulakh et al, 1995).…”

5-HT 1B receptors modulate components of satiety in the rat: behavioural and pharmacological analyses of the selective serotonin 1B agonist CP-94,253

“…CP-94,253 is approximately 45-fold more selective for rat 5-HT 1B receptors compared to 5-HT 1A receptors, and has very low affinity for other 5-HT receptor subtypes (Koe et al 1992). CP-94,253 has been shown to cause a behaviourally selective hypophagia when given systemically to mildly deprived rats, and to reduce body weight gain during chronic treatment (Koe et al 1992;Halford and Blundell 1996;Lee and Simansky 1997;Schreiber et al 2000). Moreover, investigations of the behavioural action of this agonist have suggested that food intake was reduced through a decrease in meal size and an early termination of feeding (Lee and Simansky 1997).…”