Abstract:Brain chemoreceptors play a vital role in regulating blood gas homeostasis in response to acute changes in CO2 and/or pH. Serotonergic (5‐HT) neurons, which also produce and release other neuromodulatory peptides, have properties consistent with being central respiratory chemoreceptors. In addition, recent in vitro studies have highlighted important contributions of G‐protein‐coupled 5‐HT receptors (5‐HT2 and/or 5‐HT7 receptors) to the chemosensitivity of additional putative central respiratory chemoreceptors … Show more
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