Effects of serotonin and the serotonin blocker metergoline on meal patterns and macronutrient selection

Recent advances in animal models of chronic antidepressant effects: The novelty-induced hypophagia test

“…Many drug treatments and genetic manipulations alter appetite (van der Hoek and Cooper, 1994) and food preferences (Heisler et al, 1997;Leibowitz et al, 1993). Drug treatments may also induce sedative or stimulating effects, which increase and decrease feeding, respectively.…”

Effect of sibutramine on macronutrient selection in male and female rats

“…This result occurred at a dose as low as 3.2nmol into the PVN and at 7 0.6mg/kg into the IP, only during the first hour after injection at the early dark phase. Leibowitz et al (1993) examined the effect of d-norfenfluramine and fluoxetine (both at doses 3.1-25nmol), and metergoline (0.03-1.0mg/kg), a 5-HT reeeptor antagonist. These drugs were injeeted into the PVN immediately before the dark phase of250-300 gram male Sprague-Dawiey rats offered three pure macronutrient diets (CHO: 37% sucrose, 28% dextrin, and 28% comstarch; PRO: 93% casein; FAT: 86% lard) ad libitum.…”

Local perfusion of mCPP into ventromedial hypothalamic nucleus, but not into lateral hypothalamic area and frontal cortex, inhibits food intake in rats

“…In the studies of micronutrient ingestion during the local ad- Values are expressed as mean€SEM ministration of 5-HT into various hypothalamic areas, it was demonstrated that the administration into medial hypothalamus such as VMH or paraventricular hypothalamic nucleus (PVN) induced a reduction of carbohydrate rich food intake specifically, compared to fat or protein; however, administration into LH did not change macronutrient ingestion (Leibowitz et al 1993). Therefore, in contrast to the VMH, 5-HT receptors in LH might not involve inhibition of food intake.…”