Effects of Serotonin 1A or 1B Receptor Agonists on Social Aggression in Male and Female Syrian Hamsters

Joppa, Margaret; Rowe, Richard K.; Meisel, Robert L.

doi:10.1016/s0091-3057(97)00277-3

Cited by 63 publications

(36 citation statements)

References 28 publications

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“…If aggression is inhibited by the 5HT 1A R, as some studies suggest (Joppa et al, 1997;Sanchez, 1997;Simon et al, 1998;Sperry et al, 2005), then this receptor type may reside in a circuit that rapidly inhibits enhanced EOD response in weakly electric fish, perhaps after a social encounter terminates or in response to confrontation with a more dominant individual. Activating the 5HT 1A R autoreceptor inhibits neuronal firing and decreases 5-HT synthesis (Perreault et al, 2003;Sperry et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

“…If the classical account of the serotonin system as an inhibitor of aggression is accurate and enhancements of the EOD in the presence of conspecifics are aggressive, then the reduction in EOD parameters following activation of the 5HT 1A R makes perfect sense, but the increase in these parameters following activation of the 5HT 2 R is unexpected. Perhaps both very low and very high levels of serotonergic activity augment the EOD, allowing fish to increase the potency of their communication signal both when dominant (low 5-HT enhances the EOD via the 5HT 1A R) and when newly challenged (high 5-HT enhances the EOD via a 5HT 2 R).If aggression is inhibited by the 5HT 1A R, as some studies suggest (Joppa et al, 1997;Sanchez, 1997;Simon et al, 1998;Sperry et al, 2005), then this receptor type may reside in a circuit that rapidly inhibits enhanced EOD response in weakly electric fish, perhaps after a social encounter terminates or in response to confrontation with a more dominant individual. Activating the 5HT 1A R autoreceptor inhibits neuronal firing and decreases 5-HT synthesis (Perreault et al, 2003;Sperry et al, 2005).…”

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confidence: 99%

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Opposing actions of 5HT1A and 5HT2-like serotonin receptors on modulations of the electric signal waveform in the electric fish Brachyhypopomus pinnicaudatus

Allee

Markham

Salazar

et al. 2008

Hormones and Behavior

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Serotonin (5-HT) is an indirect modulator of the electric organ discharge (EOD) in the weakly electric gymnotiform fish, Brachyhypopomus pinnicaudatus. Injections of 5-HT enhance EOD waveform "masculinity", increasing both waveform amplitude and the duration of the second phase. This study investigated the pharmacological identity of 5-HT receptors that regulate the electric waveform and their effects on EOD amplitude and duration. We present evidence that two sets of serotonin receptors modulate the EOD in opposite directions. We found that the 5HT 1A R agonist 8-OH-DPAT diminishes EOD duration and amplitude while the 5HT 1A R antagonist WAY100635 increases these parameters. In contrast, the 5HT 2 R agonist α-Me-5-HT increases EOD amplitude but not duration, yet 5-HT-induced increases in EOD duration can be inhibited by blocking 5HT 2A/2C -like receptors with ketanserin. These results show that 5-HT exerts bi-directional control of EOD modulations in B. pinnicaudatus via action at receptors similar to mammalian 5HT 1A and 5HT 2 receptors. The discordant amplitude and duration response suggests separate mechanisms for modulating these waveform parameters. KeywordsSerotonin; Electric organ discharge; Communication signal; 5HT 1A receptor; 5HT 2 receptor; Social interaction; Dominance hierarchy Serotonin (5-HT) is a neuromodulator so ubiquitous that hardly any physiological function or behavior is free from its direct or indirect effects. As a result, a full account of neuroendocrine control of behavior requires a thorough assessment of 5-HT's function across a wide range of circumstances, even as the pervasive presence of 5-HT in the nervous system complicates unambiguous assessment of its functions. Particularly, serotonin is involved in the regulation of diametrically opposed behaviors, aggression and subordinance (Summers and Winberg, 2006). Serotonin activity rises in both dominant and subordinate males but rapidly returns to baseline in dominants while it stays chronically high in subordinates (Overli et al., 1999;Summers and Winberg, 2006). Prior social defeat or success during aggressive interactions affects future aggressive behaviors and the activity of the serotonergic system (Winberg et al., 1992;Winberg et al., 1997b). Furthermore, social experience affects the regulatory effect of serotonin on dominant behaviors via serotonin receptors 1A and 2A (Yeh et al., 1996). Pharmaceutical 5HT 1A agonists inhibit aggression or induce submissive behaviors in a wide range of non-mammalian vertebrates including green anoles (Deckel and Fuqua, 1998), Arctic charr (Hoglund et al., 2002;Winberg and Nilsson, 1993) Bell et al., 2007). In addition, 5HT 1A receptors operate as both postsynaptic receptors and as pre-synaptic autoreceptors to either suppress or stimulate stress responses in teleosts as they do in mammals (Hoglund et al., 2002). Despite the functionally and anatomically conserved nature of the serotonin system in vertebrates (Parent et al., 1984) and the abundance of data indicating a role for 5HT ...

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Opposing actions of 5HT1A and 5HT2-like serotonin receptors on modulations of the electric signal waveform in the electric fish Brachyhypopomus pinnicaudatus

Allee

Markham

Salazar

et al. 2008

Hormones and Behavior

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“…In contrast to males, central administration of AVP in females reduces aggression, and V1aR antagonists stimulate aggression. Remarkably, despite hundreds of studies demonstrating that 5-HT inhibits aggression in males, the effects of 5-HT on aggression in females remain essentially unknown (23,24).…”

Section: Significancementioning

confidence: 99%

Serotonin and arginine–vasopressin mediate sex differences in the regulation of dominance and aggression by the social brain

Terranova

Song

Larkin

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

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There are profound sex differences in the incidence of many psychiatric disorders. Although these disorders are frequently linked to social stress and to deficits in social engagement, little is known about sex differences in the neural mechanisms that underlie these phenomena. Phenotypes characterized by dominance, competitive aggression, and active coping strategies appear to be more resilient to psychiatric disorders such as posttraumatic stress disorder (PTSD) compared with those characterized by subordinate status and the lack of aggressiveness. Here, we report that serotonin (5-HT) and arginine-vasopressin (AVP) act in opposite ways in the hypothalamus to regulate dominance and aggression in females and males. Hypothalamic injection of a 5-HT1a agonist stimulated aggression in female hamsters and inhibited aggression in males, whereas injection of AVP inhibited aggression in females and stimulated aggression in males. Striking sex differences were also identified in the neural mechanisms regulating dominance. Acquisition of dominance was associated with activation of 5-HT neurons within the dorsal raphe in females and activation of hypothalamic AVP neurons in males. These data strongly indicate that there are fundamental sex differences in the neural regulation of dominance and aggression. Further, because systemically administered fluoxetine increased aggression in females and substantially reduced aggression in males, there may be substantial gender differences in the clinical efficacy of commonly prescribed 5-HT-active drugs such as selective 5-HT reuptake inhibitors. These data suggest that the treatment of psychiatric disorders such as PTSD may be more effective with the use of 5-HT-targeted drugs in females and AVP-targeted drugs in males.hamster | gender differences | agonistic | social behavior | fluoxetine P rominent sex differences occur in the incidence, development, and clinical course of many psychiatric disorders. Women, for example, have higher rates of depression and anxiety disorders such as posttraumatic stress disorder (PTSD), whereas men more frequently suffer from autism and attention deficit disorders (1-4). Because little is known about sex differences in the efficacy of treatments for these disorders, current treatment strategies are largely the same for both sexes. The development of effective treatments for both women and men can proceed with a clear understanding of sex differences in the mechanisms and etiology of psychiatric disorders. Many of these disorders are linked to deficits in adaptive social skills (5, 6); therefore, understanding the neural mechanisms underlying social engagement in both sexes is essential. In most mammalian species, social interactions among both sexes are governed by dominance relationships. As such, behaviors associated with these relationships (e.g., social recognition, stress, competitive aggression) are the foundation for social interactions and are highly relevant for understanding psychiatric disorders (7-9). Emerging genetic and environmental...

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“…If aggression modulated through the 5HT1AR, as some studies suggest (Joppa et al, 1997;Sanchez, 1997;Simon et al, 1998;Sperry et al, 2005), then the autoreceptor and post-synaptic receptor may be one circuit that rapidly inhibits and terminates enhanced EOD response in weakly electric fish. Activating the 5HT1AR inhibits neuronal firing and decreases 5-HT synthesis (Perreault et al, 2003;Sperry et al, 2005 (Barnes and Sharp, 1999;Baxter et al, 1995;Jorgensen et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

Neuroendocrine control of a dynamic communication signal

Allee¹

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Effects of Serotonin 1A or 1B Receptor Agonists on Social Aggression in Male and Female Syrian Hamsters

Cited by 63 publications

References 28 publications

Opposing actions of 5HT1A and 5HT2-like serotonin receptors on modulations of the electric signal waveform in the electric fish Brachyhypopomus pinnicaudatus

Opposing actions of 5HT1A and 5HT2-like serotonin receptors on modulations of the electric signal waveform in the electric fish Brachyhypopomus pinnicaudatus

Serotonin and arginine–vasopressin mediate sex differences in the regulation of dominance and aggression by the social brain

Neuroendocrine control of a dynamic communication signal

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