Effects of serial passage on the endocrine response and steroid metabolism of a rat mammary carcinoma

Miller, William R.

doi:10.1038/bjc.1980.234

Br J Cancer

1980

DOI: 10.1038/bjc.1980.234

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Effects of serial passage on the endocrine response and steroid metabolism of a rat mammary carcinoma

William R. Miller¹

Abstract: Summary.-A rat mammary carcinoma induced by [7][8][9][10][11][12] (Miller, 1976a) and in vivo (Miller, 1976b,c;Buchan et al., 1976). The Tumour -steroid metaboli8M.-A portion of each tumour (0-5 g) was finely sliced in KrebsRinger phosphate buffer, pH 7-4 (5 ml). An

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Cited by 2 publications

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Tumour steroid hormone synthesis and estrogen receptor status in breast cancer patients

Mason

Burns

Miller

et al. 1981

Breast Cancer Res Tr

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SummaryThe capacity of breast cancer to synthesise active androgens and estrogens has been related to estrogen receptor (ER) status in 79 postmenopausal patients with breast can;er. Although there was no quantitative relationship between levels of ER and steroid metabolism in ER positive tumours, there was (a) a positive correlation between estrogen synthesis and ER positivity and (b) increased androgen synthesis and ER negativity. This may imply an inherent difference in the handling of hormones in ER positive and negative tumours.

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Tumour steroid hormone synthesis and estrogen receptor status in breast cancer patients

Mason

Burns

Miller

et al. 1981

Breast Cancer Res Tr

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Serial Syngeneic Transplantation of Large Granular Lymphocyte Leukemia in F344 Rats

et al. 1990

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A spontaneous large granular lymphocyte (LGL) leukemia was serially transplanted in 92 male F344 rats kept under standard laboratory conditions. Serial transplantation into groups of four rats each resulted in a rapid reduction in the latent period of the disease. After 23 serial transplantations, F344 rats in groups that were injected intraperitoneally with 10(7) cells died between 12 and 16 days after transplantation. At necropsy, "transplanted" rats had enlarged mesenteric lymph nodes, thymus, and spleen. Neoplastic cells were detected in the spleen on day 3 and in peripheral blood on day 6. Extreme leukocytosis with leukemia was present on day 9. Severe hemolytic anemia coincided with a sharp increase in osmotic fragility on day 12. Splenic lymphoid depletion was observed histologically and confirmed by differential cell counts of isolated spleen cells. Analysis for surface markers of splenic lymphocytes by monoclonal antibodies and flow cytometry indicated that cells with T helper/inducer phenotypes were disproportionately decreased, while the number of T suppressor cells did not significantly change. The T helper/T suppressor lymphocyte ratio (normal = 2.09 +/- 0.35) was decreased on day 9 (0.76 +/- 0.10) and day 12 (0.25 +/- 0.04). Hemolytic anemia was not related to a decrease in the number of T suppressor cells. The passaged leukemia cell model should provide investigators with an easily maintained neoplasm of short latency with which to study pathogenesis of leukemia-related disorders.

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Effects of serial passage on the endocrine response and steroid metabolism of a rat mammary carcinoma

Abstract: Summary.-A rat mammary carcinoma induced by [7][8][9][10][11][12] (Miller, 1976a) and in vivo (Miller, 1976b,c;Buchan et al., 1976). The Tumour -steroid metaboli8M.-A portion of each tumour (0-5 g) was finely sliced in KrebsRinger phosphate buffer, pH 7-4 (5 ml). An

Cited by 2 publications

References 10 publications

Tumour steroid hormone synthesis and estrogen receptor status in breast cancer patients

Tumour steroid hormone synthesis and estrogen receptor status in breast cancer patients

Serial Syngeneic Transplantation of Large Granular Lymphocyte Leukemia in F344 Rats

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