Effects of septal stimulation in rats on heart rate and galvanic skin response

Holdstock, T. L.

doi:10.3758/bf03330747

Cited by 23 publications

(10 citation statements)

References 9 publications

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“…It is known, for example, that septal lesions impair inhibitory responses to punishment, delay the extinction of responding when reinforcers are removed, and increase response rates under differential reinforcement of low rate schedules (Grossman, 1977;Gray & McNaughton, 1983). Furthermore, there are similarities between the behavioural and physiological effects of septal lesions and stress exposure such as increased irritability, resistance to extinction and sympathetic activation (Holdstock, 1967;Chen & Amsel, 1977;Feldon & Gray, 1979;Gray, 1987). Thus, we predicted that septal inactivation might mimic the effect of footshock stress on reinstatement of heroin seeking.…”

Section: Introductionmentioning

confidence: 99%

Involvement of the medial septum in stress‐induced relapse to heroin seeking in rats

Highfield

Clements

Shalev

et al. 2000

Eur J of Neuroscience

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Intermittent footshock stress has been shown to reinstate extinguished drug-taking behaviour in rats, but the brain areas involved in this effect are to a large degree unknown. Here we studied the role of the septum in stress-induced reinstatement of heroin seeking. Rats were trained to self-administer heroin for 9-10 days (three 3-h sessions per day, 0.1 mg/kg per infusion). Following training, extinction sessions were given for 8-13 days by substituting saline for heroin, and then tests for reinstatement of heroin seeking were carried out. Reversible inactivation of the medial septum with tetrodotoxin (TTX; 1-5 ng, infused 25-40 min before the test sessions) reliably reinstated heroin seeking, mimicking the effect of 15 min of intermittent footshock. This effect of TTX was not observed after infusions made 1.5 mm dorsally into the lateral septum. In other experiments, it was found that infusions of a low, subthreshold dose of TTX (0.5 ng) into the medial septum, when combined with 2 min of footshock that in itself was ineffective, reinstated heroin seeking. Furthermore, electrical stimulation (400 microA pulses, 100 micros duration, 100 Hz frequency) of the medial septum during exposure to 10 min of intermittent footshock attenuated footshock-induced reinstatement of heroin seeking. These data suggest a role for the medial septum in stress-induced relapse to drug seeking. The septum is thought to be involved in neuronal processes underlying behavioural inhibition, thus we speculate that stressors provoke relapse by interfering with these processes.

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Section: Introductionmentioning

confidence: 99%

Involvement of the medial septum in stress‐induced relapse to heroin seeking in rats

Highfield

Clements

Shalev

et al. 2000

Eur J of Neuroscience

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“…Indeed, this area receives connections from the frontal cortex (Gaykerema et al 1991) and sends efferent fibres to different structures, including the hippocampus, amygdala and hypothalamus in rats (Berk & Finkelstein 1981, Meiback & Siege1 1967, Nieuwenhuys et al 1982, Staiger & Nunberger 1991, Dudley et al 1990. T h e septum is involved in the control of emotion-related behaviours such as the activity in a n open field (Lee et al 1988), galvanic skin response, heart rate and blood pressure changes (Covian et al 1964, Holdstock 1967. I t is also reported that septal lesions decrease the level of locomotor activity, accelerate ponderal growth, and increase the concentration of growth hormone and insulin.…”

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confidence: 99%

Septal lesions block sympathetic activation following frontal cortex stimulation in the rat

Monda

Amaro

Luca

1995

Acta Physiologica Scandinavica

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The rates of oxygen consumption, colonic and interscapular brown adipose tissue temperature, and discharge of sympathetic nerves innervating the same tissue were recorded before and after orbital frontal cortex stimulation in three groups of rats. These groups consisted of animals with electrolytic lesions of the nucleus medialis septi, with lesions of nucleus lateralis septi or with sham lesions. The values of all the variables considered were similar during the pre-stimulation time in the three groups of rats. There was an increase in all the parameters in sham-lesioned animals after electrical stimulation, while no changes were found in the two groups of injured rats. The results showed that the frontal cortex is involved in the control of thermogenesis through the activation of the sympathetic nervous system. Medial and lateral septal nuclei, in spite of their neurochemical and pharmacological differences, share a common role in the pathway from the frontal cortex to the hypothalamic area and the amygdala, which in turn drive the sympathetic nervous system.

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“…In collaboration with a number of co-workers the behavioural significance of the septal forebrain has been studied by using electrical stimulation (Holdstock 1967;Bromley & Holdstock 19697, electrophysiological recording (Chalmers & Holdstock 1969;, drug (Chalmers & Holdstock 1969;Holdstock & Ingle 1969) and ablation techniques.…”

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The Septal Forebrain in Relation to REM Sleep, Hippocampal Theta and Sensory Regulation

Holdstock

1980

South African Journal of Psychology

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Large lesions in the septal forebrain failed to influence the REM sleep of hooded rats under a number of different conditions. This was true whether the electrical activity of the cortex or the activity of the dorsal and ventral hippocampus were used as criteria to assess REM sleep. The amount of REM sleep of animals with and without lesions was the same under baseline and REM deprivations conditions, and also similar under conditions of different types of environmental noise. The most surprising finding was the persistence of hippocampal theta activity after septal co-agulation. As has been reported previously, REM deprivation causes an appreciable compensatory effect. The values of REM sleep obtained under baseline and deprivation conditions were comparable to that previously obtained in our laboratory.S. Afr. J. Psychol. 1980, 10: 55-59 Ondanks verskillende toetsomstandighede het omvattende letsels in die septale areas van die breine van laboratoriumrotte geen invloed op hulle paradoksale slaap gehad nie, ongeag of die elektriese aktiwiteit van die korteks of die aktiwiteit van die dorsale en ventrale hippokampus as maatstaf gebruik is. Die paradoksale slaap van diere met of sonder letsels was dieselfde onder kontrole-en deprivasietoestande en in verskillende toestande van omgewingsgeraas. Die verrassendste bevinding van die studie was die voortdurende aanwesigheid van hippokampale thetaaktiwiteit nadat die septale area vernietig is. 800s voorheen bevind, het ontbering van paradoksale slaap 'n duidelike kompensasie tot gevolg gehad. Die hoeveelheid paradoksale slaap wat onder basiese-en deprivasietoestande geregistreer is, is vergelykbaar met die wat voorheen in ons laboratorium bevind is.

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Effects of septal stimulation in rats on heart rate and galvanic skin response

Cited by 23 publications

References 9 publications

Involvement of the medial septum in stress‐induced relapse to heroin seeking in rats

Involvement of the medial septum in stress‐induced relapse to heroin seeking in rats

Septal lesions block sympathetic activation following frontal cortex stimulation in the rat

The Septal Forebrain in Relation to REM Sleep, Hippocampal Theta and Sensory Regulation

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