Effects of Seprafilm on peritoneal fibrinolytic system

Tarhan, Ömer Rıdvan; Eroğlu, Ahmet; Çetin, Recep; Ynce, Ayper; Bülbül, Mahmut; Altuntas, Yrfan

doi:10.1111/j.1445-2197.2005.03483.x

Cited by 16 publications

(19 citation statements)

References 10 publications

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“…The safety and efficacy of this membrane in preventing postoperative adhesion has been demonstrated in clinical and experimental studies (Becker and Dayton 1996;Kelekci et al 2004). It was pointed out that Seprafilm had no major effect on peritoneal fibrinolysis but it increased peritoneal hydroxyproline (Altuntas et al 2002;Tarhan et al 2005).…”

Section: Discussionmentioning

confidence: 99%

Pentoxifylline, a Methyl Xanthine Derivative, Reduces Peritoneal Adhesions and Increases Peritoneal Fibrinolysis in Rats

Tarhan

Barut

Sütçü

et al. 2006

Tohoku J. Exp. Med.

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Peritoneum has an intrinsic fibrinolytic activity that breaks the peritoneal adhesions. Peritoneal injuries with ischemia interfere this fibrinolytic activity and cause adhesions. Pentoxifylline, a methyl xanthine derivative, improves blood flow by decreasing its viscosity and also increases fibrinolytic activity in plasma. We hypothesized that pentoxifylline would increase peritoneal fibrinolysis and ameliorate adhesions. A rat model of peritoneal adhesion (cecal abrasion with gauze, n = 15 for each group) was used to test this hypothesis and cardinal parameters of peritoneal fibrinolysis were measured in peritoneal samples. No medication was given in control animals, while pentoxifylline was administered intraperitonealy (IP) (25 mg/kg, before abdominal closure to whole abdomen) or intravenously (IV) (25 mg/kg, for 9 days after operation) in the experimental groups. At postoperative day 10, peritoneal biopsies were obtained and adhesions were graded qualitatively. Activities and concentrations of tissue plasminogen activator (tPA), plasminogen activator inhibitor type 1 (PAI-1), tPA/PAI-1 complex and hydroxyproline contents were determined. Total adhesion scores were decreased in both treated groups. Mean levels of tPA concentration and tPA activity were increased in the treated groups compared to controls ( p < 0.001 and p = 0.001, respectively). The tPA/PAI-1 complex levels were similar among the three groups. PAI-1 levels were lower in animals receiving IP pentoxifylline compared to control animals and those treated with IV pentoxifylline ( p = 0.048, p = 0.015, respectively). Peritoneal hydroxyproline levels were similar among the three groups. Our results suggest that pentoxifylline administration either through IV or IP may reduce peritoneal adhesion formation probably by altering peritoneal fibrinolytic activity.pentoxifylline; peritoneal adhesion; tPA; PAI-1; peritoneal fibrinolysis

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Section: Discussionmentioning

confidence: 99%

Pentoxifylline, a Methyl Xanthine Derivative, Reduces Peritoneal Adhesions and Increases Peritoneal Fibrinolysis in Rats

Tarhan

Barut

Sütçü

et al. 2006

Tohoku J. Exp. Med.

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“…Therefore, it was chosen to wait 10 days before performing relaparotomy because other studies had shown high adhesion scores at the period of this time [4,5,27] . There have many adhesion scoring systems described by researchers in experimental models [4][5][6]16,17,22] . Macroscopical and histopathological evaluations were made according to semiquantitative scoring systems that had been described by Mazuji et al [24] and Hooker et al [25] .…”

Section: Discussionmentioning

confidence: 99%

“…Flunixin meglumine (non-selective COX inhibitors) are commonly used to treat animals suffering from various diseases and has been proved to prevent the formation of peritoneal adhesions in studies [1,2,7,[9][10][11][12] . Mechanical barriers such as carboxymethylcellulose, hyaluronic acid, icodextrin, polyethylene glycol, fibrin glue, oxidized regenerated cellulose, expanded polytetrafluoro ethylene, and hyaluronic acid/carboxymethylcellulose (HA/CMC) have been applied to prevent adhesion by mechanically minimizing the development of fibrin between serosal surfaces [1,2,6,13] . HA/CMC is a biosynthetic material that have been widely used in human and animals.…”

Section: Introductionmentioning

confidence: 99%

“…Early fibrinolysis, within 5 days, encourages healing of the peritoneum without adhesion formation. Inadequate fibrinolysis processes lead to persistent fibrin structures that subsequently mature into fibrous tissue, followed by organization into rigid, persistent fibrous adhesions containing blood vessels and nerve fibers [1][2][3][4][5][6] .…”

Section: Introductionmentioning

confidence: 99%

“…Many different techniques, agents, and materials have been tried to reduce adhesions [1][2][3][6][7][8][9] . Several pharmacological drugs including corticosteriod, non-steroid antiinflammatory drugs (NSAIDs), melatonin, progesterone, aprotinin, methylen blue, heparin, mitomycin C, vitamin E, and tPA have been used to prevent adhesions [1,2,8,10,11] .…”

Section: Introductionmentioning

confidence: 99%

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Effect of Hyaluronic Acid/Carboxymethylcellulose and Flunixin Meglumine Combination on the Prevention of Postoperative Intraabdominal Adhesions: An Experimental Study in Rabbits

Köm¹

2013

Kafkas Univ Vet Fak Derg

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Despite the development in the knowledge concerning pathophysiology of abdominal cavity and improvement in surgical techniques, intraabdominal adhesions are one of the most common complications in surgery. The aim of this study was to determine the effects of hyaluronic acid/carboxymethylcellulose (HA/CMC) and flunixin meglumine combination on the prevention of postoperative intraabdominal adhesions in rabbits. All the surgery were made under aseptic condition under general anesthesia. A 2x2 cm area of parietal peritoneum was resected on the abdominal wall after median laparotomy. Twenty-four adult, male rabbits were divided into four groups equally. Groups were evaluated as C (control), S (HA/CMC), F (flunixin meglumine), and SF (HA/CMC and flunixin meglumine combination). No medication was given to the rabbits in group C. In S and SF groups, 3x3 cm of HA/CMC applied directly to peritoneal defect. In F and SF groups, flunixin meglumine was administred 1.1 mg/kg for 5 days intraperitoneally. Relaparotomy was performed 10 days after surgery. As a result of macroscopical and histopathological evaluations, the scores of adhesion in the S, F, and SF groups were significantly lower than those of the control group (P<0.05). Adhesion scores in SF group were lower as compared to S and F groups (P<0.05). It is observed that HA/CMC and flunixin meglumine combination can be used more effective on the prevention of postoperative intraabdominal adhesions in rabbits.

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Bioabsorbable Materials in Revision Sinus Surgery

Chandra¹,

Kern²

Revision Sinus Surgery

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Effects of Seprafilm on peritoneal fibrinolytic system

Abstract: The adhesion preventive effect of Seprafilm is not directly related in peritoneal fibrinolytic activity. Instead, the physical properties (barrier, hydroflotation and sliconizing effect) of the membrane are primarily responsible for adhesion prevention.

Cited by 16 publications

References 10 publications

Pentoxifylline, a Methyl Xanthine Derivative, Reduces Peritoneal Adhesions and Increases Peritoneal Fibrinolysis in Rats

Pentoxifylline, a Methyl Xanthine Derivative, Reduces Peritoneal Adhesions and Increases Peritoneal Fibrinolysis in Rats

Effect of Hyaluronic Acid/Carboxymethylcellulose and Flunixin Meglumine Combination on the Prevention of Postoperative Intraabdominal Adhesions: An Experimental Study in Rabbits

Bioabsorbable Materials in Revision Sinus Surgery

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