Effects of Semprex-D and Diphenhydramine on Learning in Young Adults with Seasonal Allergic Rhinitis

Vuurman, E.F.P.M.; Veggel, Loe Ma van; Sanders, Ronald L.; Muntjewerff, N.; O’Hanlon, James F.

doi:10.1016/s1081-1206(10)63435-7

Cited by 80 publications

(34 citation statements)

References 3 publications

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“…Nevertheless, in our population of patients with moderate SAR complaints this did not result in significantly impaired driving performance, or memory and psychomotor impairment. Although this is the first study examining the complex ability of driving a car in real-life circumstances, laboratory studies examining more simple skills and abilities in patients with SAR did show significant impairment [5,7,8]. A possible explanation for the differences in learning and memory effects may be that Vuurman and colleagues [7,8] tested primary school children, a group that may be more vulnerable to the sedative effects of SAR when compared to the adults who participated in our study.…”

Section: Discussionmentioning

confidence: 99%

“…Sedation may be a direct result of histamine overload during allergic reactions in patients suffering from seasonal or perennial rhinitis. Sedation caused by SAR may result in impaired cognitive and psychomotor functioning [5], decreased productivity [6], impaired learning [7,8], poorer psychological functioning [9] and reduced quality of life [10][11][12]. Thus, SAR itself has shown to interfere with daily activities.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Seasonal Allergic Rhinitis on Driving Ability, Memory Functioning, Sustained Attention, and Quality of Life §

Mets¹,

Volkerts²,

Dunnebier³

et al. 2008

TOALLJ

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Abstract:Background: Seasonal allergic rhinitis (SAR) has shown to affect quality of life and impair cognitive functioning.Objective: The objective of this study was to compare driving ability, memory, and psychomotor performance during grass pollen season with winter season in untreated patients with SAR. Methods:Patients with SAR were trained and tested during the grass pollen season (summer) and winter. An on-the-road driving test during normal traffic conditions was performed. Primary parameter is the Standard Deviation of Lateral Position (SDLP), i.e. the weaving of the car. In addition, a word learning test and continuous performance test were performed and quality of life was assessed. Patients were included if in winter the Total 5-Symptoms Score (T5SS) was < 3 and in summer the T5SS was > 3.Results: 70 patients were recruited of which 22 started the study. Fifteen patients completed the study of which 11 met the inclusion criteria. These 11 patients had a mean T5SS of 6.8 in summer and 0.6 in winter. Patient reported a significantly reduced overall quality of life during grass pollen season (p<0.0001). No significant effects were found on the driving test, except a significant (but not relevant) decrease in mean speed during the grass pollen season (p<0.035). No significant effects were found on the word learning test and continuous performance test. Conclusion:Our data suggest that moderate SAR symptoms do not impair driving ability, memory functioning and continuous performance. However, given the small sample size future studies should confirm these findings.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of Seasonal Allergic Rhinitis on Driving Ability, Memory Functioning, Sustained Attention, and Quality of Life §

Mets¹,

Volkerts²,

Dunnebier³

et al. 2008

TOALLJ

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show abstract

“…Some medications currently being used to treat this disorder, which significantly impacts learning, school performance, and attendance [1][2][3], may adversely affect the central nervous system and contribute to learning impairment [4]. In many cases, children with allergic rhinitis are also diagnosed with, and treated for, attention deficit/hyperactivity disorder (ADHD).…”

Section: Introductionmentioning

confidence: 99%

Attention Deficit Disorder and Allergic Rhinitis - Are They Related?

Melamed¹

2016

Int J Aller Medcations

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The association between ADHD and allergy remains controversial. Our previous findings suggest that nerve growth factor may link the nervous and immune systems. The primary objective of this study was to determine if a combination of cetirizine + methylphenidate is effective in children with comorbid ADHD and allergic rhinitis. We also examined the role of nerve growth factor in these comorbidities. Our randomized, double-blind, placebo-controlled, crossover study enrolled 38 children diagnosed with comorbid ADHD and allergy using cetirizine ( = 12), sustained-release methylphenidate ( = 12), or cetirizine + methylphenidate ( = 14). Endpoints compared baseline to posttreatment evaluations for allergic rhinitis and ADHD scores. Serum nerve growth factor levels were measured using ELISA. For allergy endpoints, combination therapy produced results superior to individual therapy. For ADHD, similar scores were achieved for individual therapy; however, combination therapy resulted in improved scores. Nerve growth factor levels were downregulated following this trend. We conclude that ADHD and allergic rhinitis may have common mechanism and represent a comorbid condition that links the nervous system to the immune system. Further studies are needed.

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“…The ethanolamines, such as diphenhydramine, are particularly prone to cause sedation (Carruthers et al 1978). Moreover, the administration of diphenhydramine further reduces learning ability in patients with seasonal allergic rhinitis in whom learning performances are already impaired by allergy symptoms (Vuurman et al 1996).…”

Section: Introductionmentioning

confidence: 99%

Effect of pertussis toxin on baclofen- and diphenhydramine-induced amnesia

1998

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The e¤ect of pretreatment with pertussis toxin at the doses of 0.25 and 0.50 µg per mouse ICV on the amnesic e¤ect produced by baclofen (0.1 4 mg kg 1 IP), diphenhydramine (15 30 mg kg 1 IP) and scopolamine (0.5 5 mg kg 1 IP) was investigated in the mouse passive avoidance test. Ten days after a single injection of pertussis toxin, baclofen (2 4 mg kg 1 IP) amnesia was prevented. By contrast, pertussis toxin had no e¤ect on diphenhydramine-and scopolamineinduced amnesia. Pretreatment with pertussis toxin at both doses used did not impair motor coordination of the mice, as revealed by the rota-rod test. The present results indicate that the activation of pertussis toxinsensitive G-proteins represents an important transduction step in memory impairment induced by GABA B (γ-aminobutyric acid B) agonists, but not by antihistaminic and antimuscarinic drugs.

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Effects of Semprex-D and Diphenhydramine on Learning in Young Adults with Seasonal Allergic Rhinitis

Cited by 80 publications

References 3 publications

Effects of Seasonal Allergic Rhinitis on Driving Ability, Memory Functioning, Sustained Attention, and Quality of Life §

Effects of Seasonal Allergic Rhinitis on Driving Ability, Memory Functioning, Sustained Attention, and Quality of Life §

Attention Deficit Disorder and Allergic Rhinitis - Are They Related?

Effect of pertussis toxin on baclofen- and diphenhydramine-induced amnesia

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