Effects of selenium supplementation on glucose homeostasis, inflammation, and oxidative stress in gestational diabetes: Randomized, double-blind, placebo-controlled trial

Asemi, Zatollah; Jamilian, Mehri; Mesdaghinia, Elaheh; Esmaillzadeh, Ahmad

doi:10.1016/j.nut.2015.04.014

Cited by 114 publications

(103 citation statements)

References 64 publications

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“…In the first study, 70 women with gestational diabetes were supplemented with Se at a dose of 200 µg per day for six weeks. Improved glucose homeostasis was observed as reflected by decreased levels of FPG and serum insulin as well as decreased HOMA-IR values (homeostasis model of assessment of insulin resistance) [23]. The second study was conducted in 70 women with polycystic ovary syndrome.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Selenium Supplementation on Glucose Homeostasis and the Expression of Genes Related to Glucose Metabolism

et al. 2016

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The aim of the study was to evaluate the effect of selenium supplementation on the expression of genes associated with glucose metabolism in humans, in order to explain the unclear relationship between selenium and the risk of diabetes. For gene expression analysis we used archival samples of cDNA from 76 non-diabetic subjects supplemented with selenium in the previous study. The supplementation period was six weeks and the daily dose of selenium was 200 µg (as selenium yeast). Blood for mRNA isolation was collected at four time points: before supplementation, after two and four weeks of supplementation, and after four weeks of washout. The analysis included 15 genes encoding selected proteins involved in insulin signaling and glucose metabolism. In addition, HbA1c and fasting plasma glucose were measured at three and four time points, respectively. Selenium supplementation was associated with a significantly decreased level of HbA1c but not fasting plasma glucose (FPG) and significant down-regulation of seven genes: INSR, ADIPOR1, LDHA, PDHA, PDHB, MYC, and HIF1AN. These results suggest that selenium may affect glycemic control at different levels of regulation, linked to insulin signaling, glycolysis, and pyruvate metabolism. Further research is needed to investigate mechanisms of such transcriptional regulation and its potential implication in direct metabolic effects.

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Section: Discussionmentioning

confidence: 99%

The Effect of Selenium Supplementation on Glucose Homeostasis and the Expression of Genes Related to Glucose Metabolism

et al. 2016

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“…In pregnant women with gestational diabetes mellitus, selenium supplementation produces a significant reduction in fasting plasma glucose and serum insulin levels (Asemi et al, 2015). A recent study on metabolic alteration inducted in rats, have shown that compound 30 (Fig 6) has a homeostatic effects on glucose metabolism and restored triglycerides, colesterol, glycemia and lactate levels .…”

Section: The 20th International Electronic Conference On Synthetic Ormentioning

confidence: 97%

<strong>Organoselenium compounds, an overview on the biological activities beyond antioxidant properties</strong>

Leo

Sancineto

Messina

et al. 2016

Proceedings of the 20th International Electronic Conference on Synthetic Organic Chemistry

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“…Therefore in spite of the observations by Fett et al, it is still conceivable that selenium deficiency is related to PPCM, at least in some parts of the world, such as the Sahel regions of Africa [20,29]. Although selenium supplementation has been used safely in Keshan disease and for other indications in pregnant women with beneficial effects, it has not been previously systematically used to treat PPCM [19,30,31].…”

Section: Selenium Deficiency Hypothesismentioning

confidence: 99%

Rationale and Design for the Peripartum Cardiomyopathy in Nigeria (PEACE) Registry

Karaye

Mohammed

Okeahialam

2018

ICFJ

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Background: Nigeria probably has the highest burden of Peripartum Cardiomyopathy (PPCM) in the world. The primary objective is to describe the burden, ventricular remodelling and outcomes (rehospitalisation rate, cardio-embolic events and survival) of PPCM in Nigeria. In the sub-studies, we aim to describe the relationship between selenium deficiency, oxidative stress and PPCM, the impact of sodium selenite supplementation on cardiac function in PPCM, and the prevalence of selenium deficiency and its relationship with cardiac function in apparently healthy pregnant women.Methods: The main Registry and the first sub-study are prospective longitudinal studies, while the second sub-study is an open-label randomised trial. 36 study centres across Nigeria have been registered and 10 of them are already recruiting subjects. Patients will be recruited from June to December 2017 and followed up till December 2018. Serum selenium and glutathione peroxidase will be assayed at recruitment for consecutive PPCM patients with LV ejection fraction (LVEF) <45% at 6 months postpartum. 200 subjects with selenium deficiency will be randomised into treatment (Selenium Selenite 200µg tablets daily for 3 months) and control arms. In the second sub-study, 120 apparently healthy pregnant women will be recruited at 28-38 weeks of gestation and reviewed at 6-8 weeks postpartum, and their serum selenium and GPO levels will be measured at recruitment.Conclusion: This will be the largest systematic evaluation of PPCM in Nigeria, and it is hoped that the information will assist in developing locally applicable treatment guidelines and policies for the disease.

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Effects of selenium supplementation on glucose homeostasis, inflammation, and oxidative stress in gestational diabetes: Randomized, double-blind, placebo-controlled trial

Cited by 114 publications

References 64 publications

The Effect of Selenium Supplementation on Glucose Homeostasis and the Expression of Genes Related to Glucose Metabolism

The Effect of Selenium Supplementation on Glucose Homeostasis and the Expression of Genes Related to Glucose Metabolism

<strong>Organoselenium compounds, an overview on the biological activities beyond antioxidant properties</strong>

Rationale and Design for the Peripartum Cardiomyopathy in Nigeria (PEACE) Registry

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