Effects of selenium supplementation on glucose homeostasis and free androgen index in women with polycystic ovary syndrome: A randomized, double blinded, placebo controlled clinical trial

Hosseinzadeh, Fatemeh; Hosseinzadeh‐Attar, Mohammad Javad; Yekaninejad, Mir Saeed; Rashidi, Batool Hossein

doi:10.1016/j.jtemb.2016.01.002

Cited by 40 publications

(69 citation statements)

References 48 publications

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“…For evaluation of the patient's overall FI, the Barthel index was used111214). This index evaluates the subject's level of independence for performing ten basic activities of daily living, namely, eating, personal hygiene, use of toilet, bathing, dressing and undressing, sphincter control, deambulation, transfer from chair to bed and climbing up and down stairs14).…”

Section: Methodsmentioning

confidence: 99%

“…This index evaluates the subject's level of independence for performing ten basic activities of daily living, namely, eating, personal hygiene, use of toilet, bathing, dressing and undressing, sphincter control, deambulation, transfer from chair to bed and climbing up and down stairs14). The Barthel index is one of the most widely used generic rating scales for measurement of activity limitations in patients with neuromuscular and musculoskeletal conditions, as especially recommended for functional assessment of elderly people.…”

Section: Methodsmentioning

confidence: 99%

“…The activities are assessed on a scale of four categories classified as 0 to 15 or 0 to 3 points, and the patients can score a maximum of 100 points in the former case or 20 points in the latter. Patients can be classified into the following categories: independent or functionally independent (20 points); slightly dependent (range, 15 to 19 points); moderately dependent (range, 10 to 14 points); and severely dependent (range, 0 to 9 points)111214).…”

Section: Methodsmentioning

confidence: 99%

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Quality of Life and Functional Independence in Patients with Osteoarthritis of the Knee

Araújo¹,

Castro²,

Daltro³

et al. 2016

Knee Surg Relat Res

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PurposeTo verify the association between functional independence (FI) and quality of life (QOL) in patients with knee osteoarthritis.Materials and MethodsA cross-sectional study composed of 93 patients with knee osteoarthritis was performed. Osteoarthritis was stratified according the classification of Ahlbach. For evaluation of the patient's overall FI, the Barthel index was used. The patient's QOL was measured by means of the Medical Outcomes Study 36–Item Short Form Health Survey (SF-36) questionnaire.ResultsThe mean age of the patients was 60 years (range, 54.0 to 69.5 years) and only 32 patients (34.3%) were found to be independent. Dependent or independent individuals presented difference in all domains of the QOL including physical function (p=0.001), role-physical (p=0.005), bodily pain (p=0.001), general health (p=0.004), vitality (p=0.009), social function (p=0.010), role-emotional (p=0.002) and mental health (p=0.001). Correlation between FI and QOL was different for all domains of the SF-36. Correlation with FI was strongest for physical function (r=0.609, p<0.001), followed by the domains of bodily pain (r=0.410, p<0.001) and mental health (r=0.402, p<0.001).ConclusionsOur data demonstrated a strong association of FI with QOL and positive correlations with all QOL domains, indicating the greater the FI is, the higher the QOL is.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Quality of Life and Functional Independence in Patients with Osteoarthritis of the Knee

Araújo¹,

Castro²,

Daltro³

et al. 2016

Knee Surg Relat Res

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“…Characteristics and the main outcomes of the 10 articles [12][13][14][15][16][17][18][19][20][21] included in the systematic review are summarized in ▶Table 1. The trials were published between 2013 and 2018.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Of all the identified studies, six studies were conducted in Iran. five studies [12,16,19,20,22] used a randomized clinical trial design, whereas the others used a case-control design. All of the five trials used 200 μg Se o r a l l y.…”

Section: Study Characteristicsmentioning

confidence: 99%

Selenium and Polycystic Ovary Syndrome; Current Knowledge and Future Directions: A Systematic Review

et al. 2019

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Polycystic ovary syndrome (PCOS), as the most common endocrine disorder in reproductive-aged women, is recognized by hyperandrogenism and insulin resistance. Selenium (Se) potentially possesses therapeutic effects on PCOS due to antioxidant and insulin-like properties. This systematic review evaluates the potential role of Se in the complications of PCOS. A systematic review was performed on published studies reporting the effects of Se on PCOS. Three major databases including PubMed, Scopus, and Google Scholar were searched until December 2018. A total of 7 human studies and two in vitro studies met the inclusion criteria. Two out of three case-control studies showed that serum Se levels tend to decrease in patients with PCOS. Of four studies that evaluated the impact of Se supplementation on insulin resistance, only one study showed protective effects of Se against insulin resistance. Two out of three studies reported the antioxidant effect of Se. Few studies investigating anti-androgenic effect of Se presented controversial results. There were three studies that evaluated the anti-hyperlipidemic effect of Se, of which two surveys indicated the lowering effects of Se on VLDL and LDL-cholesterol. The reviewed studies confirmed inverse relationships between serum Se levels and some androgenic hormones in PCOS. Se is able to attenuate insulin resistance and dyslipidemia. The available data are currently insufficient to support the protective effects of Se on PCOS.

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Chinese herbal medicine for subfertile women with polycystic ovarian syndrome

Zhou

Zhang

et al. 2016

Cochrane Database of Systematic Reviews

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There is insufficient evidence to support the use of CHM for women with PCOS and subfertility. No data are available on live birth, and there is no consistent evidence to indicate that CHM influences fertility outcomes. However there is very limited low quality evidence to suggest that the addition of CHM to clomiphene may improve pregnancy rates. There is insufficient evidence on adverse effects to indicate whether CHM is safe.

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Effects of selenium supplementation on glucose homeostasis and free androgen index in women with polycystic ovary syndrome: A randomized, double blinded, placebo controlled clinical trial

Cited by 40 publications

References 48 publications

Quality of Life and Functional Independence in Patients with Osteoarthritis of the Knee

Quality of Life and Functional Independence in Patients with Osteoarthritis of the Knee

Selenium and Polycystic Ovary Syndrome; Current Knowledge and Future Directions: A Systematic Review

Chinese herbal medicine for subfertile women with polycystic ovarian syndrome

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