Effects of selenium on endothelial dysfunction and metabolic profile in low dose streptozotocin induced diabetic rats fed a high fat diet

Öztürk, Zeynep; Gürpınar, Tuğba; Vural, Kamıl; Boyacıoğlu, Sedat; Korkmaz, Mehmet; Var, Ahmet

doi:10.3109/10520295.2015.1042050

Cited by 35 publications

(30 citation statements)

References 41 publications

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“…On the other hand, in our study, there were no signs of oxidative stress and endothelial damage in hypercholesterolemic rats that did not receive treatment. These findings also significantly differ from some published earlier experimental studies that have found links between high fat/high cholesterol diet, endothelial dysfunction and oxidative stress (Oztürk et al , ; Kobayasi et al , ). A possible explanation for these contradictory results is that the duration of administration may not long be enough to observe the influence of dietary fat on oxidative stress and the antioxidant effects of OLE.…”

Section: Dıscussıoncontrasting

confidence: 99%

“…that have found links between high fat/high cholesterol diet, endothelial dysfunction and oxidative stress (Oztürk et al, 2015;Kobayasi et al, 2010). A possible explanation for these contradictory results is that the duration of administration may not long be enough to observe the influence of dietary fat on oxidative stress and the antioxidant effects of OLE.…”

Section: Discussionmentioning

confidence: 99%

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Olive Leaf Extract Improves the Atherogenic Lipid Profile in Rats Fed a High Cholesterol Diet

et al. 2015

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Coronary heart disease because of atherosclerosis is still the most common cause of mortality. Elevated levels of low-density lipoprotein and total cholesterol are major risk factors for atherosclerotic cardiovascular disease. The aim of this study was to evaluate the effects of the olive leaf extract on serum lipid profile, early changes of atherosclerosis and endothelium-dependent relaxations in cholesterol-fed rats. For this purpose, rats were fed by 2% cholesterol-enriched or standard chow for 8 weeks. Some rats in each group were also fed orally by olive leaf extract at doses of 50 or 100 mg/kg/day. Atorvastatin at dose of 20 mg/kg of body weight daily was also given as positive control. After 8 weeks, lipid profiles of rat serums were analyzed. Antioxidant enzyme activities (superoxide dismutase and glutathione peroxidase) and degree of lipid peroxidation (malondialdehyde levels) were also measured in the hearts isolated from rats. In addition, expression of adhesion molecules and endothelium-dependent relaxations of isolated thoracic aortas of rats were evaluated. Total cholesterol and LDL-cholesterol levels were found to be increased in cholesterol-fed rats, and both doses of olive leaf extract and atorvastatin significantly decreased those levels. In conclusion, because the olive leaf extract attenuates the increased cholesterol levels, it may have beneficial effects on atherosclerosis.

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Section: Dıscussıoncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Olive Leaf Extract Improves the Atherogenic Lipid Profile in Rats Fed a High Cholesterol Diet

et al. 2015

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“…Low Se intake leads to severe changes in the vessel walls in spontaneously hypertensive rats, whereas Se supplementation slows down the elastin degradation and degenerative changes of the vessel walls [17]. Se supplementation improved the impairment of endothelium-dependent vasorelaxation in thoracic aorta of diabetic rats, possibly by regulating the antioxidant enzyme and NO release [43]. Furthermore, ACh dependent relaxation of aortic rings has been shown to be significantly diminished in vitamin E- and Se-deficient rats with hypercholesterolemia, compared to vitamin E- and Se-sufficient rats with hypercholesterolemia [44].…”

Section: Discussionmentioning

confidence: 99%

Reduced Dietary Selenium Impairs Vascular Function by Increasing Oxidative Stress in Sprague-Dawley Rat Aortas

Stupin

Ćosić

Novak

et al. 2017

IJERPH

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This study aimed to determine whether low dietary Se content affects the function and mechanisms mediating the vascular relaxation of rat aortas, and to test the role of oxidative stress in observed differences. Male Sprague Dawley (SD) rats were maintained for 10 weeks on low Se (low-Se group; N = 20) or normal Se content (norm-Se group; N = 20) rat chow. Dose responses to acetylcholine (ACh; 10−9–10−5M) and the response to reduced pO2 were tested in noradrenaline-precontracted aortic rings in the absence/presence of the nitric oxide synthase (NOS) inhibitor nitro-l-arginine methyl ester (l-NAME), the cyclooxygenase 1 and 2 (COX-1, 2) inhibitor Indomethacin, and the antioxidative agent Tempol in tissue bath. mRNA expression of glutathione peroxidase 1 (GPx1), catalase (CAT), and Cu/Zn superoxide dismutase (SOD) was measured in rat aortas. Oxidative stress (Thiobarbituric Acid Reactive Substances; TBARS), antioxidative plasma capacity (ferric reducing ability of plasma assay; FRAP), and protein levels of GPx1 were measured in plasma and serum samples, respectively. Reduced ACh-induced relaxation (AChIR) (dominantly mediated by NO) in the low-Se group compared to the norm-Se group was restored by Tempol administration. Hypoxia-induced relaxation (HIR) (dominantly mediated by COX-1, 2), TBARS, and FRAP as well as GPx1 serum concentrations were similar between the groups. mRNA GPx1 expression in rat aortas was significantly decreased in the low-Se compared to the norm-Se group. These data suggest that low dietary Se content increases the local oxidative stress level, which subsequently affects the NO-mediated vascular response.

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“…Başarılı bir model ucuz, kolay uygulanabilir ve tip 2 diyabet tedavisine yönelik, pratik olarak kolay test edilebilir parametreleri içermelidir. (19,20).…”

Section: U N C O R R E C T E Dunclassified

Diabetes, Oxidative Stress and Endothelial Dysfunction

OZTURK¹

2018

Bezmialem Science

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U n c o r r e c t e d DİYABET, OKSİDATİF STRES VE ENDOTEL DİSFONKSİYONU Özet Kardiyovasküler hastalıklar, diyabetik hastalarda en sık görülen morbidite ve mortalite nedenidir. Diyabette endotel disfonksiyonunda oksitadif stres önemli bir rol oynamaktadır. Oksidatif stres durumlarında, serbest oksijen radikalleri insülin direncini arttırıp pankreas beta hücrelerini de etkileyebilir. Diyabetin patogenezinin anlaşılmasında çeşitli deneysel modeller hayvanlarda oluşturulmakta olup özellikle yağlı diyet içerenler, insülin direnci oluşturduğundan tip 2 diyabeti en iyi taklit eden modellerdir. Diyabette lipid peroksidasyonunda da bir artış olduğu bilinmektedir. Bu durum yine oksidatif stresle ilişkilidir. Diyabette endotel disfonksiyonu, vazokonstrüksiyon ve vazodilatasyon arasında dengesizlikle kendini gösterir. Büyük boy arterlerde nitrik oksit, endotele bağlı gevşemede ana rolü üstlenmektedir. Nitrik oksidin anormal üretimi ya da yanıtının diyabette görülen vasküler ve endotel disfonksiyonuna katkıda bulunmaktadır. Oksidatif stres, nitrik oksit düzeylerini azaltır ve endotel bağımlı vazodilatasyonun bozulmasına neden olur. Bu nedenle son yıllarda diyabetik komplikasyonların tedavisine yönelik araştırmalar, antioksidan maddelere odaklanmıştır. Tedavide amaç oksidatif stresi, lipid ve glukoz düzeylerini düşürmektir. Böylelikle endotel disfonksiyonu iyileştirilip diyabete bağlı vasküler komplikasyonların önüne geçilebilir. AbstractCardiovascular diseases are the most common cause of morbidity and mortality in diabetic patients. Oxidative stress plays an important role in diabetic endothelial dysfunction. Free oxygen radicals may increase insulin resistance and affect pancreatic beta cells under conditions of oxidative stress. Several experimental animal models to understand the diabetes pathogenesis have been developed, and the model including high fat diet which leads to insulin resistance is the best animal model to mimic type 2 diabetes. In diabetes, it is well known that there is an increase in lipid peroxidation in diabetic cases. This condition is also associated with oxidative stress. Endothelial dysfunction creates imbalance between vasoconstriction and vasodilatation. In large arteries, nitric oxide plays a main role in endothelium-dependent vasodilatation. Abnormal production or response of nitric oxide contributes vascular and endothelial dysfunction in diabetes. Oxidative stress reduces the levels of nitric oxide and diminishes endothelium-dependent vasodilatation. In recent years, therefore, the studies to treat the diabetic complications have focused on antioxidant agents.The goal of the treatment is to decrease oxidative stress, as well as lipid and glucose levels.Thus, endothelial dysfunction may be ameliorated and diabetic vascular complications can be avoided.

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Effects of selenium on endothelial dysfunction and metabolic profile in low dose streptozotocin induced diabetic rats fed a high fat diet

Cited by 35 publications

References 41 publications

Olive Leaf Extract Improves the Atherogenic Lipid Profile in Rats Fed a High Cholesterol Diet

Olive Leaf Extract Improves the Atherogenic Lipid Profile in Rats Fed a High Cholesterol Diet

Reduced Dietary Selenium Impairs Vascular Function by Increasing Oxidative Stress in Sprague-Dawley Rat Aortas

Diabetes, Oxidative Stress and Endothelial Dysfunction

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