Effects of Moro orange juice (Citrus sinensis(l.) Osbeck) on some metabolic and morphological parameters in obese and diabetic rats

Abstract

BACKGROUNDNutritional intervention with the use of phytochemicals is an important method for the treatment and prevention of a metabolic syndrome. The objective of this study was to chemically characterize Moro orange juice. The influence of juice intake on metabolic parameters of rats that were obese, diabetic or both by means of body mass management after the activation of anthocyanins during refrigerated storage was also assessed.RESULTSJuice intake reversed most of the metabolic abnormalities exhibited by obese rats, including reduction of body mass and improvement of the biochemical profile. The loss of body mass by diabetic animals and obese and diabetic animals was not attributed to juice intake, but to type I diabetes mellitus. In these animals, no improvement was observed in the biochemical profile, liver enzymes and glycemia, so this treatment model was deemed unfeasible.CONCLUSIONThe beneficial effects cannot be explained only by the anthocyanin C3G present in the juice, but rather, by the synergism between all the components. Studies in humans are needed to determine whether the ingestion of this orange can be recommended as an effective strategy to prevent or ameliorate complications of obesity. © 2020 Society of Chemical Industry

A review of the lipolytic effects and the reduction of abdominal fat from bioactive compounds and moro orange extracts

“…In experimental models, the nutritional intervention with Moro orange juice was able to reverse most of the metabolic abnormalities related to obese rats, including reduced body mass and improved biochemical profile (decreased triacylglycerol (21.35%), total cholesterol (14.0%) and LDL-cholesterol (16.2%) and increase in HDL-cholesterol) ( Magalhães et al., 2020 ).…”

“… Reduction of hepatic cholesterol content, cholesterol esterification and increase the activity of LDL receptors (decreases the plasma concentrations of remaining chylomicrons and LDL). [( Magalhães et al, 2020 )] Citrus sinensis Human 250 mL–700 mL or 400 mg Approximately 12 weeks Orange juice or dry extract of Moro orange juice Few evidences and non-significant results associated with anthropometric measurements. Improvement of the biochemical profile.…”

Protective effects of red orange (Citrus sinensis [L.] Osbeck [Rutaceae]) extract against UVA-B radiation-induced photoaging in Skh:HR-2 mice

“…For this reason, several reported beneficial effects of ROC have attracted scientific attention, such as its anti-inflammatory properties, anti-oxidant activity, and cardiovascular protection [ 12 16 29 30 31 32 33 ]. In this study, we evaluated the effects of 13-week oral ROC administration on UV-irradiated skin damage in Skh:HR-2 mice.…”

Effectiveness of “Moro” Blood Orange Citrus sinensis Osbeck (Rutaceae) Standardized Extract on Weight Loss in Overweight but Otherwise Healthy Men and Women—A Randomized Double-Blind Placebo-Controlled Study

“…Moro orange is a rich source of active compounds such as hydroxycinnamic acid, flavone glycosides and ascorbic acids, including anthocyanins with an average content of about 140 mg/L [ 18 , 19 , 20 , 21 ]. Evidence to date has shown that blood oranges demonstrate potent antioxidant activity and cytoprotective effects that reflect their substantial role in preventing chronic pathological conditions such as cardiovascular diseases and in many forms of cancers [ 21 , 22 , 23 , 24 , 25 ]. Moreover, a recent study showed that a red orange standardized extract is able to inhibit 3T3-L1 differentiation, by downregulating adipogenic gene and enzymes together with the modulation of adiponectin secretion and leptin release [ 26 ].…”