Effects of <scp>JNK</scp>1/2 on the inflammation cytokine <scp>TNF</scp>‐α‐enhanced production of <scp>MMP</scp>‐3 in human dental pulp fibroblast‐like cells

Goda, Seiji; Kato, Yu; Domae, Eisuke; Hayashi, Hiroyuki; Tani‐Ishii, Nobuyuki; Iida, Joji; Ikeo, Takashi

doi:10.1111/iej.12411

Cited by 24 publications

(18 citation statements)

References 25 publications

(40 reference statements)

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“…39 The recent study demonstrated enhancement of MMP-3 production in dental pulp fibroblast-like cells when stimulated with TNF-a, suggesting its role in angiogenesis. 40 Level of MMP-3 was also found significantly increase in oral squamous cell carcinoma patients compared to the healthy control. Moreover, the increase expression of MMP-3 correlated with the stage of tumour suggesting the participation of this enzyme in the pathogenesis and progression of the disease.…”

Section: Discussionmentioning

confidence: 70%

TNF-α stimulates MMP-3 production via PGE2 signalling through the NF-kB and p38 MAPK pathway in a murine cementoblast cell line

Sanchavanakit¹,

Saengtong²,

Manokawinchoke³

et al. 2015

Archives of Oral Biology

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Section: Discussionmentioning

confidence: 70%

TNF-α stimulates MMP-3 production via PGE2 signalling through the NF-kB and p38 MAPK pathway in a murine cementoblast cell line

Sanchavanakit¹,

Saengtong²,

Manokawinchoke³

et al. 2015

Archives of Oral Biology

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“…Bacterial lipopolysaccharide (LPS)-induced release of pro-inflammatory mediators elevate levels of MMP-1, -2 and -3 in acute pulpitis [109,110]. Release of MMP-3 can activate other MMP members, mediate collagen degradation in the extracellular matrix, induce inflammation and promote angiogenesis [111]. MMP-13 is the major collagenase in dental pulp tissues and is effective in cleaving type II collagen.…”

Section: Anti-mmp Activitiesmentioning

confidence: 99%

Quaternary ammonium-based biomedical materials: State-of-the-art, toxicological aspects and antimicrobial resistance

Jiao

Niu

et al. 2017

Progress in Polymer Science

483

317

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a b s t r a c tMicrobial infections affect humans worldwide. Many quaternary ammonium compounds have been synthesized that are not only antibacterial, but also possess antifungal, antiviral and anti-matrix metalloproteinase capabilities. Incorporation of quaternary ammonium moieties into polymers represents one of the most promising strategies for preparation of antimicrobial biomaterials. Various polymerization techniques have been employed to prepare antimicrobial surfaces with quaternary ammonium functionalities; in particular, syntheses involving controlled radical polymerization techniques enable precise control over macromolecular structure, order and functionality. Although recent publications report exciting advances in the biomedical field, some of these technological developments have also been accompanied by potential toxicological and antimicrobial resistance challenges. Recent evidenced-based data on the biomedical applications of antimicrobial quaternary ammonium-containing biomaterials that are based on randomized human clinical trials, the golden standard in contemporary medicinal science, are included in the present review. This should help increase visibility, stimulate debates and spur conversations within a wider scientific community on the implications and plausibility for future developments of quaternary ammonium-based antimicrobial biomaterials.Published by Elsevier B.V.

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“…reported (Goda et al 2015. The protein products of the JNK pathway are involved in apoptosis, neurodegeneration, cell differentiation and proliferation, inflammation and cytokine production mediated by the activation of transcription factors (Goda et al 2015).…”

Section: Molecular Events Involved In Inflammatory Responsesmentioning

confidence: 99%

Disclosing the physiology of pulp tissue for vital pulp therapy

2018

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The discovery that dentine is a reservoir of bioactive molecules that can be recruited on demand has attracted efforts to develop new protocols and materials for vital pulp therapy (VPT). The noncollagenous proteins (NCPs) present in the dentine extracellular matrix (ECM) include growth factors (TGF-β1, BMP-7, FGF-2, IGF-1 and IGF-2, NGF and GDNF), extracellular matrix molecules (DSP, DPP, BSP, DMP-1 and DSPP) and both anti-inflammatory and pro-inflammatory chemokines and cytokines (TNF-α, IL-1, IL-6 and IL-10). Molecules such as DSP and DPP are mainly expressed by odontoblasts, and they are cleaved products from dentine sialophosphoprotein (DSPP). Some molecules, such as TGF-β1, specifically interact with decorin/biglycan in dentine. Although TGF-β1 increases the expression and secretion of NGF in human pulp cells, NGF induces mineralization and increases the expression of DSPP and DMP-1. Furthermore, GDNF may act as a cell survival factor and mitogen during tooth injury and repair. Pulp capping materials, such as MTA and calcium hydroxide, can solubilize bioactive dentine molecules (TGF-β1, NGF and GDNF) that stimulate tertiary dentinogenesis. The binding of these signalling molecules leads to activation of several signalling transduction pathways involved in dentinogenesis, odontoblast differentiation and inflammatory responses, such as the p38 MAPK, NF-kβ and Wnt/β-catenin signalling pathways. Understanding the cascade of cellular and molecular events underlying the repair and regeneration processes provides a reasonable new approach to VPT through a targeted interaction between tooth tissue and bioactive molecules.

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Effects of JNK1/2 on the inflammation cytokine TNF‐α‐enhanced production of MMP‐3 in human dental pulp fibroblast‐like cells

Abstract: Goda S, Kato Y, Domae E, Hayashi H, Tani-Ishii N, Iida J, Ikeo T. Effects of JNK1/2 on the inflammation cytokine TNF-a-enhanced production of MMP-3 in human dental pulp fibroblast-like cells.

Cited by 24 publications

References 25 publications

TNF-α stimulates MMP-3 production via PGE2 signalling through the NF-kB and p38 MAPK pathway in a murine cementoblast cell line

TNF-α stimulates MMP-3 production via PGE2 signalling through the NF-kB and p38 MAPK pathway in a murine cementoblast cell line

Quaternary ammonium-based biomedical materials: State-of-the-art, toxicological aspects and antimicrobial resistance

Disclosing the physiology of pulp tissue for vital pulp therapy

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