Effects of Nigella sativa oil supplementation on selected metabolic parameters and anthropometric indices in patients with coronary artery disease: A randomized, double‐blind, placebo‐controlled clinical trial

Abstract

Various metabolic parameters are risk factors related to the amplified risk of atherosclerotic cardiovascular disease. A wide variety of data exist on Nigella sativa (NS) and metabolic parameters. The current study is designed to examine NS supplementation on lipid profile, blood pressure, glycemic control, anthropometric indices, and insulin resistance in individuals with coronary artery disease (CAD). In a randomized, double-blind, placebo-controlled clinical trial, 60 patients with CAD received either 2 g of NS oil or sunflower oil as a placebo for 8 weeks. Biochemical and anthropometric measurements were assessed.

Efficacy of nigella sativa oil on endothelial function and atherogenic indices in patients with coronary artery diseases: A randomized, double‐blind, placebo‐control clinical trial

“…Numerous mechanisms have been elucidated for the potential hypolipidemic effect of NS. As indicated in our previous study (Tavakoli‐Rouzbehani, Abbasnezhad, Kheirouri, & Alizadeh, 2021), a higher concentration of PUFA exist in NS in the form of oil than powder or seed. Approximately 54% of NS oil consists of PUFA, especially linoleic acid (LA); (C18:2); (supplementary Table S1), which contributes to inhibiting VLDL secretion, increasing lipoprotein lipase activity, fatty acid oxidation, and leading to higher clearance of TG (Hallajzadeh et al, 2020).…”

Antihypertensive effects of Nigella sativa supplementation: An updated systematic review and meta‐analysis of randomized controlled trials

“…Totally, 1527 subjects were included, and the dates of publications were between 2008 and 2022. Among the 22 studies, 19 were parallel studies (Amin et al, 2015; Bin Sayeed et al, 2013; Datau et al, 2010; Dehkordi & Kamkhah, 2008; Fallah Huseini et al, 2013; Hadi et al, 2021; Ibrahim et al, 2014; Mahdavi et al, 2015; Naeimi et al, 2020; Qidwai et al, 2009; Rachman & Darmawan, 2017; Rashidmayvan et al, 2019; Rashidmayvan et al, 2022; Rizka et al, 2018; Salem et al, 2021; Sayeed et al, 2014; Shoaei‐Hagh et al, 2021; Siddiqui et al, 2022; Tavakoli‐Rouzbehani et al, 2021), and three were crossover (Latiff et al, 2014; Mohtashami, 2019; Razmpoosh et al, 2021). The sample size ranged from 32 to 200 participants and the duration of the study ranged from 4 to 16 weeks.…”

“…The baseline BMI varied between 21.8 and 32.4 kg/m 2 . Studies were conducted in the following countries: Iran (Dehkordi & Kamkhah, 2008; Fallah Huseini et al, 2013; Hadi et al, 2021; Mahdavi et al, 2015; Mohtashami, 2019; Naeimi et al, 2020; Rashidmayvan et al, 2019; Rashidmayvan et al, 2022; Razmpoosh et al, 2021; Shoaei‐Hagh et al, 2021; Tavakoli‐Rouzbehani et al, 2021), Saudi Arabia (Badar et al, 2017; Salem et al, 2021), Indonesia (Datau et al, 2010; Rachman & Darmawan, 2017; Rizka et al, 2018), Pakistan (Amin et al, 2015; Qidwai et al, 2009; Siddiqui et al, 2022), Malaysia (Ibrahim et al, 2014; Latiff et al, 2014), and Bangladesh (Bin Sayeed et al, 2013; Sayeed et al, 2014). N. sativa in forms of powder (doses from 0.5 to 3 g/day) and oil (doses from 0.1 to 4.2 g/day) were used in the studies.…”

Is Nigella sativa an Effective Bodyweight Lowering Agent and a Mitigator of Obesity Risk? A Literature Review

“… Significant reduction of HbA 1c , TC, triglyceride, LDL, SBP, and DBP 4 Tavakoli-Rouzbehani et al 2021. 21 Double-blinded, randomized, controlled clinical trial Iran 60 patients with coronary artery disease divided into two groups: Group 1: NS Group 2: placebo 2 g of NS- oil or sunflower oil as a placebo both in the form of soft gel capsules for 8 weeks Significant reduction of BW, BMI, WC, HC W/P ratio Significant reduction of SBP, DBP, and FBG 5 Shirazi et al 2020. 22 Double-blinded randomized, controlled trial Iran 140 menopausal women within the age of 45–60 years old, who were suffering from metabolic syndrome divided into two equal groups: Group 1: NS n=70 Group 2: Control n=7 500 mg NS- vinegar extract daily or placebo (starch) for 8 weeks No significant difference in BW, and WC Significant difference in LDL, triglyceride, TC, and FBG 6 Moustafa et al 2019 23 Open label randomized clinical trial Egypt 21 Newly diagnosed diabetic patients with age range 18–60 years and not on antidiabetic medications.…”