Effects of Schistosoma Mansoni and HIV-1 Co-Exposure on Pulmonary Vascular Pathology

Cano, D. Morales; Parreño, G. Mondejar; García, Santiago; Barreira, Bianca; Callejo, María; Ruiz, S. Esquivel; Kumar, Ramesh; Kosanovic, Djuro; Mathie, Alistair; Malavé, E. Fernández; Graham, Brian B.; Schermuly, Ralph T.; Moreno, Laura; Vizcaíno, Francisco Pérez; Cogolludo,; Butrous, Ghazwan

doi:10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4204

Cited by 3 publications

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“…Schistosoma and the HIV infections are independent risk factors for the development of pulmonary vascular diseases, including PAH ( Kolosionek et al, 2013 ; Butrous, 2015 ). Although the effects of co-infection with SARS-COV-2 on pulmonary vascular disease development are still unknown; co-exposure of these pathogens may potentiate pulmonary vascular disease resulting in different remodeling phenotypes as the dysregulation of inflammatory responses induced by one may influence the pattern of pulmonary vascular remodeling mediated by the other ( Morales Cano et al, 2019 ).…”

Section: Pathobiology Of Pulmonary Vascular Diseases In Sars-cov-2mentioning

confidence: 99%

From acute SARS-CoV-2 infection to pulmonary hypertension

2022

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As the world progressively recovers from the acute stages of the coronavirus disease 2019 (COVID-19) pandemic, we may be facing new challenges regarding the long-term consequences of COVID-19. Accumulating evidence suggests that pulmonary vascular thickening may be specifically associated with COVID-19, implying a potential tropism of severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) virus for the pulmonary vasculature. Genetic alterations that may influence the severity of COVID-19 are similar to genetic drivers of pulmonary arterial hypertension. The pathobiology of the COVID-19-induced pulmonary vasculopathy shares many features (such as medial hypertrophy and smooth muscle cell proliferation) with that of pulmonary arterial hypertension. In addition, the presence of microthrombi in the lung vessels of individuals with COVID-19 during the acute phase, may predispose these subjects to the development of chronic thromboembolic pulmonary hypertension. These similarities raise the intriguing question of whether pulmonary hypertension (PH) may be a long-term sequela of SARS-COV-2 infection. Accumulating evidence indeed support the notion that SARS-COV-2 infection is indeed a risk factor for persistent pulmonary vascular defects and subsequent PH development, and this could become a major public health issue in the future given the large number of individuals infected by SARS-COV-2 worldwide. Long-term studies assessing the risk of developing chronic pulmonary vascular lesions following COVID-19 infection is of great interest for both basic and clinical research and may inform on the best long-term management of survivors.

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Section: Pathobiology Of Pulmonary Vascular Diseases In Sars-cov-2mentioning

confidence: 99%

From acute SARS-CoV-2 infection to pulmonary hypertension

2022

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Pulmonary Vascular Diseases Associated with Infectious Disease—Schistosomiasis and Human Immunodeficiency Viruses

Butrous

2021

Clinics in Chest Medicine

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Human immunodeficiency viruses and their effect on the pulmonary vascular bed

Butrous

2021

American Journal of Physiology-Lung Cellular and Molecular Phys

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December 1, 2021, is “World AIDS Day,” reminding us that HIV infection is still widespread and that many of its long-term effects can be deadly. One of these complications is its effect on the pulmonary vascular beds, leading to an increase in the pulmonary pressure, causing the clinical manifestation of “pulmonary hypertension.” Unfortunately, we are still far from fully understanding the prevalence, mechanics, and pathobiology of “HIV pulmonary hypertension,” especially in Africa and other developing countries where HIV is still common. In addition, the impact of other factors like coinfection and illicit drugs can add and modify the effect on the pulmonary vascular bed, complicating the pathological and clinical effects of HIV. Thus, “World AIDS Day” can be an impetus to pursue further research in this area.

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Effects of Schistosoma Mansoni and HIV-1 Co-Exposure on Pulmonary Vascular Pathology

Cited by 3 publications

References 0 publications

From acute SARS-CoV-2 infection to pulmonary hypertension

From acute SARS-CoV-2 infection to pulmonary hypertension

Pulmonary Vascular Diseases Associated with Infectious Disease—Schistosomiasis and Human Immunodeficiency Viruses

Human immunodeficiency viruses and their effect on the pulmonary vascular bed

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