Effects of SCH 23390 and eticlopride on cocaine-seeking produced by cocaine and WIN 35,428 in rats

Schenk, Susan; Gittings, Dave

doi:10.1007/s00213-002-1276-y

Cited by 37 publications

(17 citation statements)

References 31 publications

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“…Given the neurochemical and behavioural similarities between methylphenidate and cocaine , it is likely that dopamine is involved. Dopamine receptor antagonists block the priming or reinstating effects of cocaine Bachtell et al 2005;Khroyan et al 2000Khroyan et al , 2003Norman et al 1999;Schenk and Gittings 2003;Schmidt et al 2005;Sun and Rebec 2005), and it is reasonable to suspect that either D1 or D2 antagonists might have the same effect on methylphenidate-induced reinstatement. Some evidence indicates a role for noradrenaline in the reinstating effects of stimulants.…”

Section: Discussionmentioning

confidence: 97%

Characterization of methylphenidate self-administration and reinstatement in the rat

et al. 2008

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Section: Discussionmentioning

confidence: 97%

Characterization of methylphenidate self-administration and reinstatement in the rat

et al. 2008

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“…Together, these studies suggest that D 2 receptors could play a major role in eliciting relapse to cocaine seeking when environmental stimuli such as cocaine-related cues or stress activate the mesolimbic dopamine system (Phillips et al, 2003;Pruessner et al, 2004), while D 1 receptor tone may provide inhibitory regulation over cocaine seeking. In contrast to agonists, both D 1 and D 2 receptor antagonists block reinstatement of cocaine seeking in rats (Weissenborn et al, 1996;Ciccocioppo et al, 2001;Norman et al, 2002;Vorel et al, 2002;Schenk and Gittings, 2003;Gilbert et al, 2005), and indiscriminately block the reinstating effects of nucleus accumbens agonist administration (Bachtell et al, 2005), consistent with well-characterized enabling and synergistic interactions between D 1 and D 2 receptors on behavioral responses (Waddington and Daly, 1993).…”

Section: Introductionmentioning

confidence: 82%

Addiction-Related Alterations in D1 and D2 Dopamine Receptor Behavioral Responses Following Chronic Cocaine Self-Administration

Edwards

Whisler

Fuller

et al. 2006

Neuropsychopharmacol

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The cocaine-addicted phenotype can be modeled in rats based on individual differences in preferred levels of cocaine intake and a propensity for relapse in withdrawal. These cocaine-taking and -seeking behaviors are strongly but differentially regulated by postsynaptic D 1 and D 2 receptors in the mesolimbic dopamine system. Thus, we determined whether addiction-related differences in cocaine selfadministration would be related to differential sensitivity in functional D 1 and D 2 receptor responses. Using a population of 40 outbred Sprague-Dawley rats trained to self-administer cocaine for 3 weeks, we found that animals with higher preferred levels of cocaine intake exhibited a vertical and rightward shift in the self-administration dose-response function, and were more resistant to extinction from cocaine self-administration, similar to phenotypic changes reported in other models of cocaine addiction. After 3 weeks of withdrawal from cocaine self-administration, high intake rats were subsensitive to the ability of the D 1 agonist SKF 81297 to inhibit cocaine-seeking behavior elicited by cocaine priming, but supersensitive to cocaine seeking triggered by the D 2 agonist quinpirole, when compared to low intake rats. Additionally, high intake rats developed profound increases in locomotor responses to D 2 receptor challenge from early to late withdrawal times, whereas low intake rats developed increased responsiveness to D 1 receptor challenge. In a second experiment, responses to the mixed D 1 /D 2 agonist apomorphine and the NMDA glutamate receptor antagonist MK-801 failed to differ between low and high intake rats. These findings suggest that cocaine addiction is related specifically to differential alterations in functional D 1 and D 2 receptors and their ability to modulate cocaine-seeking behavior.

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“…Both D1-and D2-like receptor mechanisms are known to mediate the reinstatement of cocaine-seeking behavior. Peripheral administration of D1-like antagonists attenuate drug-seeking behavior induced by a priming injection of cocaine (Norman et al, 1999;Spealman et al, 1999;Khroyan et al, 2000;Alleweireldt et al, 2003;Khroyan et al, 2003;Schenk and Gittings, 2003). Similarly, administration of D2 dopamine receptor antagonists blocks cocaine priming-induced drug-seeking behavior (Spealman et al, 1999;Khroyan et al, 2000;Schenk and Gittings, 2003).…”

Section: Introductionmentioning

confidence: 99%

“…Peripheral administration of D1-like antagonists attenuate drug-seeking behavior induced by a priming injection of cocaine (Norman et al, 1999;Spealman et al, 1999;Khroyan et al, 2000;Alleweireldt et al, 2003;Khroyan et al, 2003;Schenk and Gittings, 2003). Similarly, administration of D2 dopamine receptor antagonists blocks cocaine priming-induced drug-seeking behavior (Spealman et al, 1999;Khroyan et al, 2000;Schenk and Gittings, 2003). While D1-and D2-like receptor mechanisms in general have been widely investigated in cocaine reinforcement and reinstatement, the paucity of selective drugs for the D2-like receptor subtypes has made it difficult to define a definitive role for each subtype in the reinstatement of cocaine seeking.…”

Section: Introductionmentioning

confidence: 99%

Administration of the D2 Dopamine Receptor Antagonist Sulpiride into the Shell, but not the Core, of the Nucleus Accumbens Attenuates Cocaine Priming-Induced Reinstatement of Drug Seeking

Anderson

Schmidt

Pierce

2005

Neuropsychopharmacol

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Enhanced dopamine transmission in the nucleus accumbens plays an important role in cocaine priming-induced reinstatement of drugseeking behavior. However, the contribution of each dopamine receptor subtype to this behavior remains unclear. The present experiments were designed to assess the role of D2-like dopamine receptors in the nucleus accumbens core and shell subregions in cocaine priming-induced reinstatement of drug seeking. Rats were trained to lever press for cocaine using a fixed ratio (FR) 5 schedule of reinforcement. After approximately 18 days of cocaine self-administration, the animals underwent an extinction phase during which cocaine was replaced with saline. Daily extinction sessions were conducted until responding was less than 10% of the response rate maintained by cocaine self-administration. Following the extinction phase, priming-induced reinstatement of cocaine-seeking behavior was assessed. A range of doses of antagonists selective for D2-(sulpiride, 0.2 or 2.0 mg), D3-(U99194A, 3.9 or 7.8 mg), or D4-(L-750,667, 5.5 or 11 mg) dopamine receptors were microinjected into either the nucleus accumbens core, shell or lateral septum prior to a priming injection of cocaine (10 mg/kg, i.p.). Following administration into the shell, but not core or lateral septum, sulpiride dose-dependently attenuated reinstatement induced by a cocaine priming injection. In contrast, U99194A and L-750,667 failed to influence cocaine seeking at any of the doses tested in either accumbal subregion. Collectively, these findings indicate that activation of D2 dopamine receptors mediates cocaine priming-induced reinstatement of cocaine seeking in a region-specific manner within the nucleus accumbens.

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Effects of SCH 23390 and eticlopride on cocaine-seeking produced by cocaine and WIN 35,428 in rats

Cited by 37 publications

References 31 publications

Characterization of methylphenidate self-administration and reinstatement in the rat

Characterization of methylphenidate self-administration and reinstatement in the rat

Addiction-Related Alterations in D1 and D2 Dopamine Receptor Behavioral Responses Following Chronic Cocaine Self-Administration

Administration of the D2 Dopamine Receptor Antagonist Sulpiride into the Shell, but not the Core, of the Nucleus Accumbens Attenuates Cocaine Priming-Induced Reinstatement of Drug Seeking

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