Effects of San-Huang-Xie-Xin-Tang on U46619-induced increase in pulmonary arterial blood pressure

Tsai, Hsin-Hung; Chen, Ing‐Jun; Lo, Yi-Ching

doi:10.1016/j.jep.2008.02.024

Cited by 34 publications

(22 citation statements)

References 41 publications

(49 reference statements)

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“…We demonstrate that SHXT attenuates lipopolysaccharide (LPS) and Helicobacter pylori -induced inflammatory responses [10–12]. We also reveal the potential benefits of SHXT used in the treatment of pulmonary hypertension [13]. We further prove the potential protective mechanisms of SHXT on activated microglia- and 6-OHDA-induced neurotoxicity via its anti-inflammatory and antioxidative properties [14].…”

Section: Introductionmentioning

confidence: 96%

Neuroprotective Effects of San-Huang-Xie-Xin-Tang in the MPP⁺/MPTP Models of Parkinson’s DiseaseIn VitroandIn Vivo

Shih

Tseng

et al. 2012

Evidence-Based Complementary and Alternative Medicine

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San-Huang-Xie-Xin-Tang (SHXT), composed of Coptidis rhizoma, Scutellariae radix, and Rhei rhizoma, is a traditional Chinese medicine used for complementary and alternative therapy of cardiovascular and neurodegenerative diseases via its anti-inflammatory and antioxidative effects. The aim of this study is to investigate the protective effects of SHXT in the 1–methyl–4–phenylpyridinium (MPP+)/1–methyl–4–phenyl–1,2,3,6–tetrahydropyridine (MPTP) models of Parkinson's disease. Rat primary mesencephalic neurons and mouse Parkinson disease model were used in this study. Oxidative stress was induced by MPP+ in vitro and MPTP in vivo. In MPP+-treated mesencephalic neuron cultures, SHXT significantly increased the numbers of TH-positive neurons. SHXT reduced apoptotic signals (cytochrome and caspase) and apoptotic death. MPP+-induced gp91phox activation and ROS production were attenuated by SHXT. In addition, SHXT increased the levels of GSH and SOD in MPP+-treated neurons. In MPTP animal model, SHXT markedly increased TH-positive neurons in the substantia nigra pars compacta (SNpc) and improved motor activity of mice. In conclusion, the present results reveal the evidence that SHXT possesses beneficial protection against MPTP-induced neurotoxicity in this model of Parkinson's disease via its antioxidative and antiapoptotic effects. SHXT might be a potentially alternative and complementary medicine for neuroprotection.

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Section: Introductionmentioning

confidence: 96%

Neuroprotective Effects of San-Huang-Xie-Xin-Tang in the MPP⁺/MPTP Models of Parkinson’s DiseaseIn VitroandIn Vivo

Shih

Tseng

et al. 2012

Evidence-Based Complementary and Alternative Medicine

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“…Several herbs in BSYSC that we studied were also known to play important roles in inhibitory signal pathway. For examples, gastrodin, the main constituent of Gastrodiae Rhizoma , down-regulated the expression of the neuronal cytoskeleton remodeling-related negative regulators Slit1 and RhoA in the hippocampus of rat model of depression [60], San-Huang-Xie-Xin-Tang containing Rhei Radix et Rhizoma attenuated ROCK-II protein expression in U46619-induced primary pulmonary smooth muscle cells [61]; additionally, Leonuri Herba , Scorpio and Gastrodiae Rhizoma were shown have neuroprotective and neuroregenerative effect in vivo and in vitro [62–65]. Moreover, the molecules identified in BSYSC like forsythiaside, acteoside were reported for neuroprotective effects [66–71].…”

Section: Discussionmentioning

confidence: 99%

Effects of Bu Shen Yi sui capsule on NogoA/NgR and its signaling pathways RhoA/ROCK in mice with experimental autoimmune encephalomyelitis

Fang

Wang

Zheng

et al. 2017

BMC Complement Altern Med

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BackgroundAxon growth inhibitory factors NogoA/Nogo receptor (NgR) and its signaling pathways RhoA/Rho kinase (ROCK) play a critical role in the repair of nerve damage in multiple sclerosis (MS). Bu Shen Yi Sui Capsule (BSYSC) is an effective Chinese formula utilized to treat MS in clinical setting and noted for its potent neuroprotective effects. In this study, we focus on the effects of BSYSC on promoting nerve repair and the underlying mechanisms in mice with experimental autoimmune encephalomyelitis (EAE), an animal model of MS.MethodsThe EAE mouse model was induced by injecting subcutaneously with myelin oligodendrocyte glycoprotein (MOG) 35–55 supplemented with pertussis toxin. BSYSC was orally administrated at dose of 3.0 g/kg once a day for 40 days. The levels of protein gene product (PGP) 9.5, p-Tau, growth associated protein (GAP) -43, KI67 and Nestin in the brain or spinal cord on 20 and 40 day post-induction (dpi) were detected via immunofluorescence and Western blot analysis. Furthermore, NogoA/NgR and RhoA/ROCK signaling molecules were studied by qRT-PCR and Western blot analysis.ResultsTwenty or 40 days of treatment with BSYSC increased markedly PGP9.5 and GAP-43 levels, reduced p-Tau in the brain or spinal cord of mice with EAE. In addition, BSYSC elevated significantly the expression of KI67 and Nestin in the spinal cord 40 dpi. Further study showed that the activation of NogoA/NgR and RhoA/ROCK were suppressed by the presence of BSYSC.ConclusionsBSYSC could attenuate axonal injury and promote repair of axonal damage in EAE mice in part through the down-regulation of NogoA/NgR and RhoA/ROCK signaling pathways.

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“…The NO 2 − concentration originally included in wax gourd juice is not as high as the concentration of NO 3 − (Zhong et al, 2002). Among other plants, Rhizoma coptidis, Radix scutellariae and Radix salvia emiltiorrhizae are reported to be cold/cool-natured herbs (Liu et al, 2008) and are also used for treating hypertension as traditional Chinese medicines (Sanae et al, 2001;Kim et al, 2007;Tsai et al, 2008). Plants having a cold/cool-nature might exert a hypotensive effect.…”

Section: Discussionmentioning

confidence: 99%

Nitric oxide-dependent hypotensive effects of wax gourd juice

Nakashima

Shigekuni

Obi

et al. 2011

Journal of Ethnopharmacology

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Effects of San-Huang-Xie-Xin-Tang on U46619-induced increase in pulmonary arterial blood pressure

Cited by 34 publications

References 41 publications

Neuroprotective Effects of San-Huang-Xie-Xin-Tang in the MPP⁺/MPTP Models of Parkinson’s DiseaseIn VitroandIn Vivo

Neuroprotective Effects of San-Huang-Xie-Xin-Tang in the MPP⁺/MPTP Models of Parkinson’s DiseaseIn VitroandIn Vivo

Effects of Bu Shen Yi sui capsule on NogoA/NgR and its signaling pathways RhoA/ROCK in mice with experimental autoimmune encephalomyelitis

Nitric oxide-dependent hypotensive effects of wax gourd juice

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Effects of San-Huang-Xie-Xin-Tang on U46619-induced increase in pulmonary arterial blood pressure

Cited by 34 publications

References 41 publications

Neuroprotective Effects of San-Huang-Xie-Xin-Tang in the MPP+/MPTP Models of Parkinson’s DiseaseIn VitroandIn Vivo

Neuroprotective Effects of San-Huang-Xie-Xin-Tang in the MPP+/MPTP Models of Parkinson’s DiseaseIn VitroandIn Vivo

Effects of Bu Shen Yi sui capsule on NogoA/NgR and its signaling pathways RhoA/ROCK in mice with experimental autoimmune encephalomyelitis

Nitric oxide-dependent hypotensive effects of wax gourd juice

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Product

Resources

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Neuroprotective Effects of San-Huang-Xie-Xin-Tang in the MPP⁺/MPTP Models of Parkinson’s DiseaseIn VitroandIn Vivo

Neuroprotective Effects of San-Huang-Xie-Xin-Tang in the MPP⁺/MPTP Models of Parkinson’s DiseaseIn VitroandIn Vivo