Effects of Salvia miltiorrhiza on Intercellular Adhesion Molecule 1 Protein Expression in the Lungs of Rats With Severe Acute Pancreatitis or Obstructive Jaundice

Abstract

Salvia miltiorrhiza plays a positive role in the protection of the lungs of SAP and OJ rats.

Delayed Production of IL-18 in Lungs and Pancreas of Rats with Acute Pancreatitis

“…Higher IL-18 concentrations are measured in the more severe attacks [16]. As observed in our study, high serum IL-18 concentrations are present in control rodents [15,17]. In the present study, we have shown that pancreatic and pulmonary concentrations of IL-18 have the same profile as the serum concentrations, i.e.…”

Effect of Salvia miltiorrhizae on Pulmonary Apoptosis of Rats with Severe Acute Pancreatitis or Obstructive Jaundice

“…There was no marked difference in mortality rate between the time points at 3 and 6 h after operation. At 12 h after operation, only the mortality rate in model control group was significantly higher than that in sham-operated group (P=0.037), and no marked difference in mortality rate was observed among other groups (P>0.05) [19][20][21][22][23].…”

“…Shamoperated group was performed by the injection of saline solution instead of taurocholate, this is the only difference from the model control group. Fifteen minutes after successful operation, a single dose of Salvia miltiorrhizae injection (0.4 ml/100 g body weight) was given via femoral vein to rats in treated groups while equal volume of physiological saline solution was used in the shamoperated and model control group [19][20][21][22][23].…”

“…Another 180 rats were utilized for OJ-associated experiments and randomly divided into sham-operated, model control and treated group (n=60), which were further randomly subdivided into 7, 14, 21 and 28 days groups (n=15) according to time duration after operation [19][20][21][22][23].…”

“…For rats in sham-operated groups, common bile duct was only dissociated but not ligated, and a layered suture of the abdominal wall was also performed to close the abdominal cavity. An intraperitoneal injection of Salvia miltiorrhizae injection at a dose of 0.2 ml/100 g/day was given to rats in treated groups while equal volume of physiological saline solution was used in the sham-operated and model control groups [19][20][21][22][23].…”