Effects of salubrinal on ER stress in an experimental model of polycystic ovary syndrome

Emincik, Asli; Güngör, Zeynep; Güzel, Elif

doi:10.1080/01913123.2020.1850963

Cited by 2 publications

(1 citation statement)

References 57 publications

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“…A power analysis was done by G*Power Ver. 3.0.10. software [12]. Based on a 1:1 ratio among groups, a total sample size of 24 animals would provide over 75% power to detect significant differences at a = 0.05 significance level.…”

Section: Groupsmentioning

confidence: 99%

The Effects of Thymoquinone and Vibration Forces on Rapid Palatal Expansion Relapse in Experimental Rat Models

Zincir

Bozkurt

Emincik

2023

Preprint

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Objective: The rapid palatal expansion (RPE) procedure is a frequently used treatment for malocclusion before pubertal growth. However, relapses often occur after the retention period of this procedure. In this study, we aimed to eliminate this deficiency, considering that there would be a deficiency in the new bone metabolism in the expanded area between the palatal sutures. Design: Twenty-four male Wistar rats, 7-8 weeks old, with an average weight of 200 g, were divided into 3 groups in equal numbers. 5 days of expansion was applied to all groups with 50 g of force, then a retention period of 12 days was expected. While no application was made to the control group (CG) during the retention period, mechanical vibration was applied to the vibration group (VF) at a frequency of 111 Hz and the active substance was applied to the thymoquinone group (TQ) at a dose of 10 mg/kg. Result: At the end of the retention period, all animals were sacrificed and sections were taken from the premaxillary region and histological evaluation was made in terms of osteoblast, osteoclast, capillary numbers, amount of mineralized and fibrous areas. According to the statistical analysis, TQ and VF showed more positive and similar results than CG in terms of new bone formation for all histomorphometric parameters except osteoclast numbers in the comparison of parameters in all groups (p<0.05). Conclusions: The new bone stimulation effects of non-invasive vibration force and Thymoquinone applications and ease of use can prevent relapse in the RPE.

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Section: Groupsmentioning

confidence: 99%

The Effects of Thymoquinone and Vibration Forces on Rapid Palatal Expansion Relapse in Experimental Rat Models

Zincir

Bozkurt

Emincik

2023

Preprint

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In Silico ADME Profiling of Salubrinal and Its Analogues

Zadorozhnii

Kiselev

Харченко

2022

Future Pharmacology

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This work reports on a complex in silico assessment of the ADME properties of Salubrinal (S1) and 54 of its structural analogues containing a cinnamic acid residue (S2–S40) or a quinoline ring (S41–S55). In the work for (Q)SAR forecast, the online servers SwissADME, ADMETlab, admetSAR 2.0, Molinspiration, ALOGPS 2.1, pkCSM, SuperCYPsPred, and Vienna LiverTox were used. In addition, using AutoDock Vina, molecular docking studies were performed with transporter proteins and metabolic enzymes, which were intended to interact with the test compounds. In silico assessment of the ability of the S1–S55 compounds to be absorbed in the intestine was carried out using the SAR classification models implemented in these servers, as well as on the basis of two empirical rules—Lipinski’s and Veber’s. Most of the studied compounds had moderate lipophilicity (MLogP ˂ 4.15) and a polar surface area of less than 140 Å2. They complied with Lipinski’s and Veber’s rules, and are predicted to have good intestinal absorption. In silico analysis of the distribution of the S1–S55 compounds throughout the body, the volume of distribution at steady-state (Vdss), the ability to bind to blood plasma proteins and cross the blood-brain barrier (BBB) were taken into account. Most compounds are predicted to have low or medium Vdss and the ability to cross the BBB. Molecular docking studies were carried out with the structures most important for drug binding of blood plasma proteins, human serum albumin (HSA), and alpha-1-acid glycoprotein (AGP). The studies showed that these substances can effectively bind to blood plasma proteins. When assessing metabolism, the prediction of inhibitory and substrate activity to cytochromes P450 (CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A4) was carried out. For most of these enzymes, the analyzed compounds are likely to be potential inhibitors, as indicated by the molecular docking data. For all studied compounds, a low total clearance (CLtot. ˂ 5 mL/min/kg) and a half-life time (T1/2 ˂ 3 h) are predicted.

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Effects of salubrinal on ER stress in an experimental model of polycystic ovary syndrome

Cited by 2 publications

References 57 publications

The Effects of Thymoquinone and Vibration Forces on Rapid Palatal Expansion Relapse in Experimental Rat Models

The Effects of Thymoquinone and Vibration Forces on Rapid Palatal Expansion Relapse in Experimental Rat Models

In Silico ADME Profiling of Salubrinal and Its Analogues

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