Effects of Salmon Calcitonin on Mechanical Properties of Healing and Intact Bone and Skin in Rats

Muscle contribution to tibial fracture strength in rats

“…The initial part of the load-deflection curves for the lower leg tested with intact soft-tissues (Figure 2) displayed some similarities to those obtained when testing skin specimens (Ekeland et al 1983). probably due to the longer loading time of the soft tissues.…”

Calcitonin and granulation tissue formation in the rat

“…Because increasing numbers of people are receiving systemic calcitonin therapy for osteoporosis and Paget's disease and might need surgery during the therapy, it is of interest to know whether surgical procedures can be undertaken without an increased risk of wound and healing complications. Ekeland et al [9] reported that administration of salmon calcitonin to rats reduced the strength of intact skin by about 20%-30%, but had no effects on healing skin wounds. Ekeland et al [9] reported that administration of salmon calcitonin to rats reduced the strength of intact skin by about 20%-30%, but had no effects on healing skin wounds.…”

“…On the other hand, several other investigations have shown that synthetic salmon calcitonin stimulates protein synthesis, keratogenesis and collagen formation in epidermal cells and fibroblasts during wound healing [9,11,12,18]. However, most of these studies were not based on biochemical analysis of connective tissue components but on histological and electron-microscopic analysis [11,12,18] or on testing of the tensile properties of the healing and intact tissue [9]. However, most of these studies were not based on biochemical analysis of connective tissue components but on histological and electron-microscopic analysis [11,12,18] or on testing of the tensile properties of the healing and intact tissue [9].…”

“…Controversy has arisen about whether calcitonin has an adverse [8] or beneficial effect on fracture healing. There are several reports concerning the possibly deleterious effects of calcitonin on the synthesis, mineralization, and degradation of collagen on the syn-thesis, mineralization, and degradation of collagen in healing fractures and even in intact skin [7,9]. On the other hand, several other investigations have shown that synthetic salmon calcitonin stimulates protein synthesis, keratogenesis and collagen formation in epidermal cells and fibroblasts during wound healing [9,11,12,18].…”

“…These earlier reports favor the view that calcitonin may play a role in the maturation of collagen and connective tissue cells. The rate of synthesis and turnover of collagen in bone and skin and the mineralization of bone were determined by measuring the amount of 14C-hydroxyproline and 85Sr in bone, skin, and healing wounds [8,9]. The rate of synthesis and turnover of collagen in bone and skin and the mineralization of bone were determined by measuring the amount of 14C-hydroxyproline and 85Sr in bone, skin, and healing wounds [8,9].…”