“…While the inhibitory effect of acetylsalicylic acid on platelet function (O'Brien, 1968;Weiss et al, 1968;Zucker & Peterson, 1970) and prostanoid formation (Smith & Willis, 1971;Vane, 1971) is well known (Atkinson & Collier, 1980), the effects of sodium salicylate are much less defined. Although salicylate has been shown to be similarly potent as an analgesic and anti-inflammatory drug (Atkinson & Collier, 1980; Rainsford, 1984), it has almost no effect on prostanoid formation of gastric mucosa (Ligumsky et al, 1982;Whittle et al, 1980), macrophages (Kuehl et al, 1980), ram seminal vesicle microsomes (Humes et al, 1981), or thrombocytes (Roberts et al, 1984;Smith & Willis, 1971;Vargaftig, 1978a).…”