Effects of salicylate application on the spontaneous activity in brain slices of the mouse cochlear nucleus, medial geniculate body and primary auditory cortex

Basta, Dietmar; Goetze, Romy; Ernst, Arne

doi:10.1016/j.heares.2008.02.005

Cited by 34 publications

(38 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These brain rhythms seem abnormal in patients with tinnitus (Weisz et al, 2005b,a;Llinas et al, 2005) and may indicate pathology in the cortico-thalamic loops although subjects were not always matched on their hearing levels in these studies which may act as a confound. Salicilate-induced changes in spontaneous activity (SFR) in the MGB (Basta et al, 2008) underline the role the MGB may play in tinnitus.…”

Section: Thalamusmentioning

confidence: 99%

Neural activity underlying tinnitus generation: Results from PET and fMRI

2009

View full text Add to dashboard Cite

Section: Thalamusmentioning

confidence: 99%

Neural activity underlying tinnitus generation: Results from PET and fMRI

2009

View full text Add to dashboard Cite

“…To the best of our knowledge electrophysiological recordings in dCN following salicylate treatment have only been carried out in brain slice preparations. Salicylate was found to either increase (52.9%) or decrease (47.1%) spontaneous firing rates of a subpopulation (68%) of neurons in dCN (Basta et al, 2008). In a more recent patch clamp study, spontaneous and current-evoked firing rates of fusiform cells, but not cartwheel cells, in the dCN were selectively suppressed by salicylate (Wei et al, 2010).…”

Section: Central Effectsmentioning

confidence: 99%

“…The only electrophysiological recordings of salicylate's effects on neural activity in MGB have been from extracellular recordings in vitro (Basta et al, 2008). In this study, the MGB (dorsal and ventral cells were analyzed together) exhibited the greatest proportion of neurons which had significantly altered spontaneous firing rates during salicylate application (dCN: 68.0%; MGB: 80.8%; AC: 71.4% of all recorded neurons); however, the direction of change in spontaneous firing rates of this MGB cell population were roughly equivalent (52.4% increase, 47.6% decrease).…”

Section: Central Effectsmentioning

confidence: 99%

Salicylate toxicity model of tinnitus

Stolzberg¹,

Salvi²,

Allman³

2012

Front. Syst. Neurosci.

View full text Add to dashboard Cite

Salicylate, the active component of the common drug aspirin, has mild analgesic, antipyretic, and anti-inflammatory effects at moderate doses. At higher doses, however, salicylate temporarily induces moderate hearing loss and the perception of a high-pitch ringing in humans and animals. This phantom perception of sound known as tinnitus is qualitatively similar to the persistent subjective tinnitus induced by high-level noise exposure, ototoxic drugs, or aging, which affects ∼14% of the general population. For over a quarter century, auditory scientists have used the salicylate toxicity model to investigate candidate biochemical and neurophysiological mechanisms underlying phantom sound perception. In this review, we summarize some of the intriguing biochemical and physiological effects associated with salicylate-induced tinnitus, some of which occur in the periphery and others in the central nervous system. The relevance and general utility of the salicylate toxicity model in understanding phantom sound perception in general are discussed.

show abstract

“…Portions of the thalamus, especially the medial geniculate body (MGB), are believed to play a key role in the perception of tinnitus. Spontaneous activity of MGB neurons are altered by ototoxic drugs that induce tinnitus [8]. Disrupted inhibitory neurotransmission between the thalamus and other CNS regions such as the inferior colliculus and auditory cortex may also contribute to tinnitus [9].…”

Section: Introductionmentioning

confidence: 99%