Effects of Saffron on Cognition, Anxiety, and Depression in Patients Undergoing Coronary Artery Bypass Grafting: A Randomized Double-Blind Placebo-Controlled Trial

Moazen‐Zadeh, Ehsan; Abbasi, Seyed Hesameddin; Safi-Aghdam, Hamideh; Shahmansouri, Nazila; Arjmandi-Beglar, Akram; Talasaz, Azita Hajhosseinn; Salehiomran, Abbas; Forghani, Saeedeh; Akhondzadeh, Shahin

doi:10.1089/acm.2017.0173

Cited by 27 publications

(35 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Effects of saffron on depressive symptoms. Randomeffects meta-analysis found a significant and large positive effect size for saffron reducing symptoms of depression in comparison with placebo (g ¼ 0.99, 95%CI ¼ 0.61-1.37, n ¼ 14 studies, n ¼ 716 participants, P < 0.001; Figure 2 [22][23][24][25][26][27][29][30][31][33][34][35][36][37][38][39][40]42,44 ). An additional study that could not be entered into the metaanalysis due to insufficient available data also found that saffron significantly improved depressive symptoms compared with placebo (P < 0.0001).…”

Section: Study Resultsmentioning

confidence: 99%

“…An additional study that could not be entered into the metaanalysis due to insufficient available data also found that saffron significantly improved depressive symptoms compared with placebo (P < 0.0001). 43 There was significant heterogeneity across the study data (Q ¼ When compared with antidepressants medications, there was no significant difference between saffron and medications (g ¼ À0.17, 95%CI ¼ 0.50-0.17, n ¼ 5 studies, n ¼ 210 participants, P ¼ 0.33; Figure 2 [22][23][24][25][26][27][29][30][31][33][34][35][36][37][38][39][40]42,44 ). There was a low degree of heterogeneity across the study data (Q ¼ 6.16, P ¼ 0.19, I 2 ¼35.1%).…”

Section: Study Resultsmentioning

confidence: 99%

“…41 Effects of saffron on symptoms of anxiety. Figure 3 28,[34][35][36][37]4428,[34][35][36][37]44 displays the effects of saffron monotherapy and adjunctive therapy on symptoms of anxiety across 6 RCTs compared with placebo (n ¼ 375 participants). Random-effects meta-analysis found a large positive effect size for saffron on reducing symptoms of anxiety in comparison with placebo control conditions (g ¼ 0.95, 95%CI ¼ 0.27-1.63, P < 0.006).…”

Section: Study Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Effect of saffron supplementation on symptoms of depression and anxiety: a systematic review and meta-analysis

et al. 2019

View full text Add to dashboard Cite

Context Saffron (Crocus sativus L.) has gained interest as a potential treatment in psychiatry. Objective This systematic review and meta-analysis sought to investigate the effect of saffron supplementation, as both an adjunctive therapy and monotherapy, on symptoms of depression and anxiety in clinical and general populations compared with pharmacotherapy or placebo. Data sources Using the PRISMA guidelines, a systematic literature review of randomized controlled trials was conducted. Data extraction A meta-analysis was conducted to determine treatment effect. Risk of bias was assessed using the Jadad scale. Results Twenty-three studies were included. Saffron had a large positive effect size when compared with placebo for depressive symptoms (g = 0.99, P < 0.001) and anxiety symptoms (g = 0.95, P < 0.006). Saffron also had a large positive effect size when used as an adjunct to antidepressants for depressive symptoms (g = 1.23, P = 0.028). Egger’s regression test found evidence of publication bias. Conclusions Saffron could be an effective intervention for symptoms of depression and anxiety; however, due to evidence of publication bias and lack of regional diversity, further trials are required. PROSPERO registration CRD42017070060.

show abstract

Section: Study Resultsmentioning

confidence: 99%

Section: Study Resultsmentioning

confidence: 99%

Section: Study Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Effect of saffron supplementation on symptoms of depression and anxiety: a systematic review and meta-analysis

et al. 2019

View full text Add to dashboard Cite

show abstract

“…In two studies, the effects of purified crocin was evaluated [18,19], and the aim of our meta-analysis was to focus on the efficacy of C. sativus rather than on its purified compounds. In one study [20], the patients involved were not suffering from mild to moderate depression, therefore, this study did not comply with our PICO. After reviewing the articles, it became clear that one trial, including three treatment arms, was published in two different papers [21,22].…”

Section: Resultsmentioning

confidence: 99%

The Efficacy of Saffron in the Treatment of Mild to Moderate Depression: A Meta-analysis

et al. 2018

View full text Add to dashboard Cite

Herbal products, especially extracts, have been widely used as first-line treatments for mild to moderate depression. Recently, several randomized, controlled clinical trials have been conducted to evaluate the efficacy of another plant, saffron (), in mild to moderate depression. We have carried out a literature review of currently available published randomized, controlled clinical trials to give an up-to-date evaluation of the efficacy of saffron in mild to moderate depression, compared to placebo or routinely used antidepressants. The meta-analysis is reported according to the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines using the PICO (patients, intervention, comparison, outcome) format and was conducted using the statistical programs Comprehensive Meta-analysis and RevMan. PubMed, Embase, the Cochrane Central Register of Controlled Trials, and Web of Science databases were searched for relevant studies. Only placebo or active controlled, randomized clinical studies involving patients suffering from mild to moderate depression and using pharmacological doses of saffron were included. Hedges' g was used to calculate effect sizes. Risk of bias was assessed using the Cochrane Collaboration tool, and heterogeneity was tested by both performing the Cochran's test and calculating Higgins' indicator. Eleven randomized trials were included in the qualitative analysis, and nine were pooled for statistical analysis. According to the present meta-analysis, saffron has a significant effect on the severity of depression. Available data from randomized, controlled clinical trials support that saffron is significantly more effective than placebo (g = 0.891; 95% CI: 0.369 - 1.412, p = 0.001), and non-inferior to tested antidepressant drugs (g = - 0.246; 95% CI: - 0.495 - 0.004, p = 0.053).

show abstract

“…The results did not support the hypothesis of a therapeutic effect of saffron in post-CABG patients with symptoms of depression and anxiety. The limitations of the study included a small sample size, short study duration, and non-comprehensive study design (Moazen-Zadeh et al, 2018).…”

Section: Anxietymentioning

confidence: 99%

Neuroprotective Potency of Saffron Against Neuropsychiatric Diseases, Neurodegenerative Diseases, and Other Brain Disorders: From Bench to Bedside

2020

View full text Add to dashboard Cite

The increasing morbidity rates of brain disorders and conditions such as anxiety, depression, Alzheimer's disease, and Parkinson's disease have become a severe problem in recent years. Although researchers have spent considerable time studying these diseases and reported many positive outcomes, there still are limited drugs available for their treatment. As a common traditional Chinese medicine (TCM), saffron was employed to treat depression and some other inflammatory diseases in ancient China due to its antioxidant, anti-inflammatory, and antidepressant properties. In modern times, saffron and its constituents have been utilized, alone and in TCM formulas, to treat neuropsychiatric and neurodegenerative diseases. In this review, we mainly focus on recent clinical and preclinical trials of brain disorders in which saffron was applied, and summarize the neuroprotective properties of saffron and its constituents from chemical, pharmacokinetic, and pharmacological perspectives. We discuss the properties of saffron and its constituents, as well as their applications for treating brain disorders; we hope that this review will serve as a comprehensive reference for studies aimed at developing therapeutic drugs based on saffron.

show abstract

Effects of Saffron on Cognition, Anxiety, and Depression in Patients Undergoing Coronary Artery Bypass Grafting: A Randomized Double-Blind Placebo-Controlled Trial

Abstract: The results of this trial do not support the hypothesis of potential benefits of saffron in treatment of CABG-related neuropsychiatric conditions.

Cited by 27 publications

References 61 publications

Effect of saffron supplementation on symptoms of depression and anxiety: a systematic review and meta-analysis

Effect of saffron supplementation on symptoms of depression and anxiety: a systematic review and meta-analysis

The Efficacy of Saffron in the Treatment of Mild to Moderate Depression: A Meta-analysis

Neuroprotective Potency of Saffron Against Neuropsychiatric Diseases, Neurodegenerative Diseases, and Other Brain Disorders: From Bench to Bedside

Contact Info

Product

Resources

About