Effects of saffron extract and crocin on anthropometrical, nutritional and lipid profile parameters of rats fed a high fat diet

Mashmoul, Maryam; Azlan, Azrina; Yusof, Barakatun Nisak Mohd; Khaza’ai, Huzwah; Mohtarrudin, Norhafizah; Boroushaki, Mohammad Taher

doi:10.1016/j.jff.2014.03.017

Cited by 94 publications

(94 citation statements)

References 36 publications

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“…Raised levels of serum total cholesterol, triglycerides and low density lipoprotein cholesterol are possible indication of coronary heart attack, risk of heart disease and stroke (Drummond and Brefere, 2013). This result is supported by two studies previously carried out first by Sun et al (2015), which revealed that administration of fenofibrate therapy decreased TG level and also ameliorate system oxidation and inflammation, secondly by Mashmoul et al (2014), which revealed that extract of saffron and crocin administration reduced TC and TG levels and are useful in the prevention of dyslipidemia and obesity. The mechanism of action of nutraceuticals and other related food components on lipid profile and their contribution in lipid disorder management have been reviewed by Scicchitano et al (2014).…”

Section: Discussionsupporting

confidence: 68%

Alteration of Lipid Profile and Serum Electrolytes Following Chronic Consumption of Periwinkle Extract in Rats

Ak¹,

Archibong²,

Ofem³

et al. 2015

Trends in Medical Research

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Periwinkles are important edible seafood essential to life. They are cheap and easily affordable sources of protein, although they are harvested from river waters that are made of variety of pollutants. This research therefore sought to investigate any possible alterations in some biochemical parameters of albino Wistar rats by periwinkle intake. Fifteen albino Wistar rats weighing between 200-250 g were assigned into 3 groups of 5 rats each and housed singly in metabolic cages. The rats took normal rat pellets and drinking water ad libitum. The 2 test groups received different doses (low dose -7.0 mg mLG 1 and high dose -52 mg mLG 1 ) of periwinkle extract orally, once daily. The control group received a daily oral administration of 0.6 mL of normal saline as vehicle. The feeding regimens lasted for 6 weeks, after which blood samples were collected for estimation of some biochemical parameters. Results showed that mean values of the lipid profile in control group were: TC (1.44±0.05 mg dLG when compared with control group. The periwinkle extract fed rats also had significant reduction in Na + (p<0.001) and ClG (p<0.001) concentrations compared with the control. Total cholesterol, triglyceride, LDL-c and VLDL-c concentrations were also significantly (p<0.001) reduced in the periwinkle extract fed groups compared with control. Previous study had shown that periwinkle (T. fuscatus) contains omega 3 fatty acid, which could be attributed to the beneficial effect of the extract on lipid profile and serum electrolytes observed in this study. Hence, chronic consumption of periwinkle could help alleviate dyslipidemia and other conditions associated with deleterious alterations in electrolyte concentrations. This beneficial effect of the extract on lipid profile and serum electrolytes was supported by multivariate analysis, which showed that statistically there was a significant difference in lipid profile among the different groups, F (10, 16) = 15.578, p<0.0001; Will's Lambda = 0.009, partial Eta Sq. = 0.907 and in serum electrolyte concentrations among the different groups, F (10, 16) = 222.958, p<0.0001; Wilk's Lambda = 0.000, partial Eta Sq. = 0.993.

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Section: Discussionsupporting

confidence: 68%

Alteration of Lipid Profile and Serum Electrolytes Following Chronic Consumption of Periwinkle Extract in Rats

Ak¹,

Archibong²,

Ofem³

et al. 2015

Trends in Medical Research

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“…Body mass index (BMI) and Lee index (LI) were calculated using the equations proposed by Mashmoul et al . ().

BMI = body weight false(normalg false) / body {length}^{2} false({cm}^{2} false)

LI = cube root of body weight (g) / body length (cm)

…”

Section: Methodsmentioning

confidence: 97%

“…The atherogenic index (AI) was calculated using the equation described by Mashmoul et al . (), whereas the HDL‐C to TC ratio (HTR) was calculated using the equation described by Lim et al . ().…”

Section: Methodsmentioning

confidence: 99%

Hypocholesterolaemic and hepatoprotective effects of virgin avocado oil in diet‐induced hypercholesterolaemia rats

Tan

Chong

Hamzah

et al. 2018

Int J of Food Sci Tech

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Summary Hypercholesterolaemia is a chronic disease associated with the development of nonalcoholic fatty liver disease and atherosclerosis. This study aimed to investigate the hypocholesterolaemic and hepatoprotective effects of virgin avocado oil (VAO) using diet‐induced hypercholesterolaemia rats. Male Sprague Dawley rats were fed high‐cholesterol diet for 4 weeks to induce hypercholesterolaemia. After confirming the establishment of hypercholesterolaemia model, the VAO (450 and 900 mg kg−1 body weight per day) and simvastatin (10 mg kg−1 body weight per day) were given orally while maintaining the high‐cholesterol diet for another 4 weeks. Changes in anthropometric, lipid profile, liver biomarkers and liver histology were determined. At the end of the experiment, the serum low‐density lipoprotein cholesterol (LDL‐C) and triglyceride (TG) levels were significantly reduced, while the high‐density lipoprotein cholesterol (HDL‐C) level was significantly increased in high‐dose VAO‐ (900 mg kg−1 body weight per day) and simvastatin‐treated rats when compared with their respective baseline values. The liver damage index was also markedly reduced in all treated rats. Current findings demonstrated the potential hypocholesterolaemic and hepatoprotective benefits of VAO in the preclinical study.

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“…Crocin (Sigma) was gavaged (50 mg/kg) 6 days a week for 8 weeks (19,31). For the assessment of voluntary exercise, rats were housed individually in a cage containing a wheel (1.00 m circumference, Tajhiz Gostar, Tehran, Iran).…”

Section: Animalsmentioning

confidence: 99%

Protective effect of crocin and voluntary exercise against oxidative stress in the heart of high-fat diet-induced type 2 diabetic rats

et al. 2016

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Background: Oxidative stress plays a critical role in the pathogenesis and progression of type 2 diabetes and diabeticassociated cardiovascular complications. This study investigated the impact of crocin combined with voluntary exercise on heart oxidative stress indicator in high-fat diet-induced type 2 diabetic rats. Materials and methods: Rats were divided into four groups: diabetes, diabetic-crocin, diabetic-voluntary exercise, diabetic-crocin-voluntary exercise. Type 2 diabetes was induced by high-fat diet (4 weeks) and injection of streptozotocin (intraperitoneally, 35 mg/kg). Animals received crocin orally (50 mg/kg); voluntary exercise was performed alone or combined with crocin treatment for 8 weeks. Finally, malondialdehyde (MDA), activity of antioxidant enzymes, superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) were measured spectrophotometrically. Results: Treatment of diabetic rats with crocin and exercise significantly decreased the levels of MDA (p < 0.001) and increased the activity of SOD, GPx, and CAT compared with the untreated diabetic group. In addition, combination of exercise and crocin amplified their effect on antioxidant levels in the heart tissue of type 2 diabetic rats. Conclusion: We suggest that a combination of crocin with voluntary exercise treatment may cause more beneficial effects in antioxidant defense system of heart tissues than the use of crocin or voluntary exercise alone.

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Effects of saffron extract and crocin on anthropometrical, nutritional and lipid profile parameters of rats fed a high fat diet

Cited by 94 publications

References 36 publications

Alteration of Lipid Profile and Serum Electrolytes Following Chronic Consumption of Periwinkle Extract in Rats

Alteration of Lipid Profile and Serum Electrolytes Following Chronic Consumption of Periwinkle Extract in Rats

Hypocholesterolaemic and hepatoprotective effects of virgin avocado oil in diet‐induced hypercholesterolaemia rats

Protective effect of crocin and voluntary exercise against oxidative stress in the heart of high-fat diet-induced type 2 diabetic rats

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