Abstract:Purpose
Sacubitril/valsartan is a mainstay of the treatment of heart failure with reduced ejection fraction (HFrEF); however, its effects on exercise performance yielded conflicting results. Aim of our study was to evaluate the impact of sacubitril/valsartan on exercise parameters and echocardiographic and biomarker changes at different drug doses.
Methods
We prospectively enrolled consecutive HFrEF outpatients eligible to start sacubitril/valsartan. Patie… Show more
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