Effects of saccharicterpenin on antioxidant status and urinary metabolic profile of rats

Abstract

Saccharicterpenin is a new green additive agent that is derived from the extract of Theaceae plants and has the ability to improve immunity and meat quality, increase the digestive enzyme activity, and enhance the intestinal development and growth of animals. However, the antioxidant status and systematic changes in metabolic biochemistry associated with saccharicterpenin supplementation in animals are still unknown. This study examined the effects of saccharicterpenin on the antioxidant status and urinary metabolic profile of rats. Sixteen rats were randomly distributed to 2 groups. One group was treated with 400 mg/kg body weight of saccharicterpenin, and the other group was treated with equal amount of saline. Results revealed that saccharicterpenin significantly increased the capacities of anti-hydroxyl radical (13.18%) and anti-superoxide anion (14.36%), the total antioxidant capacity (48.27%), and the activities of total superoxide dismutase (3.68%), catalase (21.52%), glutathione peroxidase (5.83%) and glutathione S-transferase (29.59%) ( P < 0.05). By contrast, the contents of malondialdehyde and glutathione were not significantly affected by saccharicterpenin ( P > 0.05). Saccharicterpenin supplementation significantly increased the urinary levels of bile acids, ethanol, α-ketoglutarate, and α-hydroxybutyrate but decreased the level of N-acetylglutamate ( P < 0.05). In summary, saccharicterpenin can enhance the antioxidant capacity and modulate the metabolism in rats.

Dietary Strategies for Relieving Stress in Pet Dogs and Cats

“…In humans and other animal species, additional substances and/or dietary formulae have been identified and investigated for their antioxidative function, such as saccharicterpenin, which is a new natural additive mainly extracted from Camellia plants [ 175 ], and the methionine/lysine proportion in the diet [ 176 ]. This evidence indicates that there are still many nutritional strategies with antioxidant potential that remain to be developed, and their application in relieving oxidative stress in cats and dogs requires further verification.…”

In-vitro screening of compatible synbiotics and (introducing) “prophybiotics” as a tool to improve gut health

“…However, in the current study, those prebiotics were not compatible with many of the LAB such as L. rhamosus and P. pentosaceus indicating the limited use of these commercial prebiotics in synergistic synbiotic application with these strains. Saccharicterpenin is a novel feed additive derived from extracts of Theaceae plants (Liu et al 2019 ) containing primarily polysaccharides and triterpinoides (Liu et al 2016 ) with wide variety of benefits to livestock including antioxidant activity (Liu et al 2019 ), intestinal development (Peng et al 2011 ), and digestive enzyme activity (Liu et al 2016 ). However, its prebiotic potential has not been studied to date.…”