Effects of running speed on a probabilistic stress fracture model

Edwards, W. Brent; Taylor, David; Rudolphi, Thomas J.; Gillette, Jason C.; Derrick, Timothy R.

doi:10.1016/j.clinbiomech.2010.01.001

Cited by 90 publications

(97 citation statements)

References 34 publications

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“…Stress fractures are a result of an overload in mechanical force, and researchers believe stress fractures are related to the magnitude of strain and loads applied to the bone (27). Edwards et al (16) explain that when bone load magnitudes are low, microdamage accumulation is limited, therefore allowing tissues adequate time to repair and remodel. However, if the load magnitudes are higher, then there is an increased likelihood that the micro damage will overwhelm the repair process of the bone, causing a greater stress fracture risk.…”

mentioning

confidence: 99%

Influence of Tibial Shock Feedback Training on Impact Loading and Running Economy

Clansey

Hanlon

Wallace

et al. 2014

Medicine &Amp; Science in Sports &Amp; Exercise

122

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mentioning

confidence: 99%

Influence of Tibial Shock Feedback Training on Impact Loading and Running Economy

Clansey

Hanlon

Wallace

et al. 2014

Medicine &Amp; Science in Sports &Amp; Exercise

122

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“…In many cases, bone tissue is often subjected to overload conditions, such as heavy-load training soldiers, high strength-training athletes, handling workers, etc. [5, 6]. These individuals often have bone pain, inflammation and other fatigue bone injury symptoms.…”

Section: Introductionmentioning

confidence: 99%

Use of an Osteoblast Overload Damage Model to Probe the Effect of Icariin on the Proliferation, Differentiation and Mineralization of MC3T3-E1 Cells through the Wnt/β-Catenin Signalling Pathway

Liu

Huang

Hao

et al. 2017

Cell Physiol Biochem

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Background/Aims: Mechanical loading plays an important role in the regulation of bone mass. However, bone cells are not always under physiological stress. In some cases, bone tissue is subjected to an overloaded mechanical environment. For example, a person who is weight training and a stevedore often experience bone pain, inflammation and other bone fatigue damage symptoms. Icariin is the major ingredient of Herba epimedii, which has been widely used for the treatment of bone injury in traditional Chinese medicine, but its mechanism remains unknown. The aim of this study was to probe the effect of icariin on the proliferation and differentiation of osteoblasts exposed to overload and to determine whether the Wnt/β-catenin signalling pathway is involved in the drug response in osteoblasts. Methods: Mouse MC3T3-E1 cells were exposed to mechanical tensile strain using a four- point bending device to create an overload damage model. An MTT assay was performed to determine the effects of icariin on MC3T3-E1 cell proliferation. The mRNA and protein levels of ALP, COL-I, OCN, RUNX2 and β-catenin were assessed using RT-PCR and immunoblotting. The protein levels of β-catenin in the MC3T3-E1 cells were also determined using fluorescence microscopy. The mineralization of osteoblasts was assessed using Alizarin Red S staining. Results: We found that icariin enhanced the proliferation of osteoblasts exposed to overload and promoted MC3T3-E1 cell differentiation and mineralization. Furthermore, the gene and protein expression levels of β-catenin and RUNX2 all increased with icariin treatment compared with those in the damage group. Conclusion: Our study suggested that icariin promotes proliferation and differentiation in osteoblasts exposed to overload. The effect of icariin on osteoblastic differentiation acted by activating the RUNX2 promoter and the Wnt/β- catenin pathway.

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“…Spine q 1 Spine 1 tilt q 2 Spine 1 bend q 3 Spine 1 rotation q 4 Spine 2 tilt q 5 Spine 2 bend q 6 Spine 2 rotate q 7 Spine 3 tilt q 8 Spine 3 bend q 9 Spine 3 rotation q 10 Spine 4 tilt q 11 Spine 4 bend q 12 Spine 4 rotation Upper Right/Left q 13 /q 22 Clavicle tilt q 14 /q 23 Clavicle rotation q 15 /q 24 Shoulder up and down q 16 /q 25 Shoulder forward and back q 17 /q 26 Shoulder twist q 18 /q 27 Elbow bend q 19 /q 28 Elbow twist q 20 /q 29 Wrist tilt q 21 /q 30 Wrist bend Neck/Head q 31 Neck tilt q 32 Neck bend q 33 Neck rotation q 34 Head tilt q 35 Head bend Lower Right/Left q 36 /q 43 Hip tilt q 37 /q 44 Hip bend q 38 /q 45 Hip rotation q 39 /q 46 Knee bend q 40 /q 47 Ankle bend q 41 /q 48 Ankle tilt q 42 /q 49 Foot bend…”

Section: Joint Angle Corresponding Movementmentioning

confidence: 99%

Probabilistic sensitivity analysis of in-vehicle reach tasks for digital human models considering anthropometric measurement uncertainty

2014

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2015). Probabilistic sensitivity analysis of in-vehicle reach tasks for digital human models considering anthropometric measurement uncertainty. Robotica, 33, pp 498-512 SUMMARYFor design using digital human models, human anthropometry data are required as input and are extracted from measurements. There is inherent error associated with these measurements which impacts the output of the simulation. Current techniques in digital human modeling applications primarily employ deterministic methods which are not well suited for handling variability in anthropometric measurement. An alternative to deterministic methods is probabilistic/sensitivity analysis. This study presents a probabilistic sensitivity approach to gain insights into how uncertainty in anthropometric measurements can affect the results of a digital human model with the specific application of vehicle-related reach tasks. Sensitivity levels are found to determine the importance of variability in each joint angle and link length to the final reach. A55-degree of freedom (DOF) digital human model is introduced to demonstrate the sensitivity approach for reach tasks. Seven right-hand reach target points and two left-hand reach target points (creating a total of 14 reach tasks) within a vehicle are used to compare the sensitivities in the joint angles and link lengths resulting from measurement uncertainty. The results show that the importance of each joint angle or link length is dependent on the characteristics of the reach task and sensitivities for joint angles, and link lengths are different for each reach task.

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Effects of running speed on a probabilistic stress fracture model

Cited by 90 publications

References 34 publications

Influence of Tibial Shock Feedback Training on Impact Loading and Running Economy

Influence of Tibial Shock Feedback Training on Impact Loading and Running Economy

Use of an Osteoblast Overload Damage Model to Probe the Effect of Icariin on the Proliferation, Differentiation and Mineralization of MC3T3-E1 Cells through the Wnt/β-Catenin Signalling Pathway

Probabilistic sensitivity analysis of in-vehicle reach tasks for digital human models considering anthropometric measurement uncertainty

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