Effects of rumen bypass melatonin feeding (RBMF) on milk quality and mastitis of Holstein cows

Yao, Songyang; Wu, Hao; Ma, Hui; Fu, Yao; Wei, Wenjuan; Wang, Tiankun; Guan, Shengyu; Yang, Hai; Li, Xiubo; Guo, Jiangpeng; Lu, Yong; Zhang, Lu; He, Changwang; Chang, Yu Han; Liu, Guoshi

doi:10.7717/peerj.9147

Cited by 8 publications

(8 citation statements)

References 42 publications

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“…Thus, in the current study, we focus whether 5-HTP supplementation also increases the melatonin synthesis in the different sections of MT plays important roles in the improvement of the yields and quality of animal products. For example, it improves the meat quality and quantity of cashmere goats [13,14], reduces somatic cell count and mastitis in dairy cattle to improve the quality of the milk [15,16]. Currently, in husbandry industrial, the methods used to regulation of MT levels in animals are primarily to alter the light/dark cycle of the environments [17,18], or by implantation [19,20], injection [21], and oral administration [22] of MT.…”

Section: Introductionmentioning

confidence: 99%

Effects of Duodenal 5-Hydroxytryptophan Perfusion on Melatonin Synthesis in GI Tract of Sheep

Pan

Wang

et al. 2021

Molecules

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The purpose of this study is to investigate the potential effects of 5-hydroxytryptophan (5-HTP) duodenal perfusion on melatonin (MT) synthesis in the gastrointestinal (GI) tract of sheep. 5-hydroxytryptophan is a precursor in the melatonin synthetic pathway. The results showed that this method significantly increased melatonin production in the mucosa of all segments in GI tract including duodenum, jejunum, ileum, cecum and colon. The highest melatonin level was identified in the colon and this indicates that the microbiota located in the colon may also participate in the melatonin production. In addition, portion of the melatonin generated by the GI tract can pass the liver metabolism and enters the circulation via portal vein. The current study provides further evidence to support that GI tract is the major site for melatonin synthesis and the GI melatonin also contributes to the circulatory melatonin level since plasma melatonin concentrations in 5-HTP treated groups were significantly higher than those in the control group. In conclusion, the results show that 10–50 mg of 5-HTP flowing into the duodenum within 6 h effectively improve the production of melatonin in the GI tract and melatonin concentration in sheep blood circulation during the day.

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Section: Introductionmentioning

confidence: 99%

Effects of Duodenal 5-Hydroxytryptophan Perfusion on Melatonin Synthesis in GI Tract of Sheep

Pan

Wang

et al. 2021

Molecules

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“…Several studies have reported that long-term melatonin treatment in cows causes reduced lactose content in milk ( Yao et al, 2020 ; Auldist et al, 2007 ; Molik, Błasiak & Pustkowiak, 2020 ; Yang et al, 2020 ). However, the underlining association between melatonin and lactose synthesis in milk has not been investigated.…”

Section: Discussionmentioning

confidence: 99%

“…Melatonin as an adjunctive treatment agent has shortened the duration of treatment ( Yang et al, 2017 ). Both subcutaneous melatonin injections ( Wu et al, 2021 ) and rumen bypass melatonin feeding ( Yao et al, 2020 ) significantly reduced somatic cell counts in milk and high somatic cell counts in milk are an indicator of mastitis. The anti-inflammatory effect of melatonin on mastitis also impacts the lactose content of milk.…”

Section: Introductionmentioning

confidence: 99%

“…It has been reported that continuously feeding rumen bypass melatonin to the cows not only significantly reduced mastitis but also the lactose content in milk ( Yao et al, 2020 ). Auldist et al reported that subcutaneous implantation of melatonin in cows lowered their milk lactose ( Auldist et al, 2007 ) and similar results were observed in dairy goats and sheep ( Molik, Błasiak & Pustkowiak, 2020 ; Yang et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

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A novel signaling transduction pathway of melatonin on lactose synthesis in cows via melatonin receptor 1 (MT1) and prolactin receptor (PRLR)

Liu,

Yao,

Meng

et al. 2023

PeerJ

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In the current study, we explored the relationship between melatonin and lactose synthesis in in vivo and in vitro conditions. We found that long-term melatonin feeding to the dairy cows significantly reduced the milk lactose content in a dose dependent manner. This lactose reduction was not associated with a negative energy balance, since melatonin treatment did not alter the fat, glucose, or protein metabolisms of the cows. To identify the potential molecular mechanisms, the cow’s mammary epithelial cells were cultured for gene expression analysis. The results showed that the effect of melatonin on lactose reduction was mediated by its receptor MT1. MT1 activation downregulated the mRNA expression of the prolactin receptor gene (PRLR), which then suppressed the gene expression of SLC35B1. SLC35B1 is a galactose transporter and is responsible for the transportation of galactose to Golgi apparatus for lactose synthesis. Its suppression reduced the lactose synthesis and the milk lactose content. The discovery of this signal transduction pathway of melatonin on lactose synthesis provides a novel aspect of melatonin’s effect on carbohydrate metabolism in cows and maybe also in other mammals, including humans.

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“…Therefore, melatonin should be tried in different forms (preserved or by-pass) and by adding it to the rations at different levels. Because it has been reported that the protein, fat and dry matter of milk increased in cows given melatonin in rumen protected from [31]. These researchers also emphasized that milk lactose level decreased with the addition of melatonin.…”

Section: Use Of Melatonin As Silage and Feed Additive In Ruminantsmentioning

confidence: 97%

Use of Melatonin as a Feed Additive

Kahraman¹,

İnanç²,

Arik³

et al. 2022

Melatonin - Recent Updates

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Melatonin is a molecule that plays an active role in reducing many stress factors in plants and has important functions in the growth, development and reproduction of plants. It has many physiological functions that directly affect feed consumption, feed efficiency, energy metabolism and immune system in animal organisms. In addition, its anti-inflammatory, antioxidant, anticancer and antiapoptotic effects are also known. While melatonin has an antioxidative effect at low doses, it can exert a prooxidant effect at high doses. It has been suggested that when melatonin is used as a silage additive, it increases the total acid content of the silage and significantly improves the silage fermentation quality by lowering the pH level and butyric acid. Although it has positive effects on mammary gland involution and general health in ruminants, its effects on yield parameters have not been proven. Broilers and layers are expected high productivity and performance, in this regard, they are faced with stress factors such as intensive feeding and housing conditions. Considering its positive effects on stress factors, health and productivity, melatonin is a promising feed additive. Effects of melatonin additive or supplements on animal productivity and health should be revealed in further studies.

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Effects of rumen bypass melatonin feeding (RBMF) on milk quality and mastitis of Holstein cows

Cited by 8 publications

References 42 publications

Effects of Duodenal 5-Hydroxytryptophan Perfusion on Melatonin Synthesis in GI Tract of Sheep

Effects of Duodenal 5-Hydroxytryptophan Perfusion on Melatonin Synthesis in GI Tract of Sheep

A novel signaling transduction pathway of melatonin on lactose synthesis in cows via melatonin receptor 1 (MT1) and prolactin receptor (PRLR)

Use of Melatonin as a Feed Additive

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