Effects of RS-2232, a Potential Antidepressant, on the Levels of Monoamines, Precursor Amino Acids and Their Related Metabolites in Mouse Brain

Interactions of Nitrogen-Containing Xenobiotics with Monoamine Oxidase (MAO) Isozymes A and B: SAR Studies on MAO Substrates and Inhibitors

“…Available preclinical and clinical data indicate that brofaromine is effective and well tolerated in patients suffering from major depression and anxiety disorders (260,261). RS-2232 (134) and its hydroxylated metabolite RS-8359 (135) also display reversible and selective MAO-A inhibition and are active as antidepressants in animal models (262,263). Recent examples of potent, reversible and highly selective MAO-B inhibitors include the imidazolyl derivative 136 (MAO-B, IC 50 ) 30 nM; MAO-A, IC 50 > 20 000 nM) (264).…”