Effects of royal jelly supplementation on glycemic control and oxidative stress factors in type 2 diabetic female: A randomized clinical trial

Pourmoradian, Samira; Mahdavi, Reza; Mobasseri, Majid; Faramarzi, Elnaz; Mobasseri, Mehrnoosh

doi:10.1007/s11655-014-1804-8

Cited by 63 publications

(37 citation statements)

References 26 publications

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“…The RJ contains vitamins such as E and C (Karaca et al, ) which have been reported that can reduce oxidative stress via MDA levels and superoxide dismutase and glutathione peroxidase activities improvement in diabetic patients erythrocytes (Pourmoradian, Mahdavi, Mobasseri, Faramarzi, & Mobasseri, ). Additionally, previous reports have indicated that RJ has membranoprotective effect during sperm freezing (Shahzad et al., ).…”

Section: Discussionmentioning

confidence: 99%

Royal jelly protects male rats from heat stress‐induced reproductive failure

et al. 2018

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Royal jelly (RJ) as an antioxidant has been shown to have attenuated oxidative stress damages in reproductive organs. The objective was carried out the effects of RJ on sperm characteristics, sperm malondialdehyde (MDA) concentration and in vitro fertilisation (IVF) outcome in heat stress (HS) exposed male rats. Forty-eight male rats were randomly divided into eight groups; group 1 received normal saline, group 2 received RJ (100 mg kg −1 day −1 ; PO), groups 3, 4 and 5 were heat-stressed (43, 39 and 37°C for 20 min per day respectively) and groups 6, 7 and 8 were heat-stressed along with RJ (43, 39 and 37°C for 20 min per day, respectively, plus RJ at a dose of 100 mg kg −1 day −1 ; PO). The HS was induced through immersion of experimental rat scrotums in a water bath. After 48 days, the HS induced remarkable diminish in sperm motility, viability and fertilising potential along with reduced blastulation rate and enhanced sperm chromatin abnormality, MDA levels and DNA damage.Nevertheless, RJ co-administration improved sperm characteristics and early embryo development as well as sperm lipid peroxidation level. Our data suggest that RJ can effectively ameliorate the experimental HS-induced infertility in rats through MDA concentration restoration and sperm characteristics and pre-implantation embryo development improvement. K E Y W O R D Searly embryo development, heat stress, malondialdehyde, rat, royal jelly, sperm

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Section: Discussionmentioning

confidence: 99%

Royal jelly protects male rats from heat stress‐induced reproductive failure

et al. 2018

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“…This questionnaire has been used in various studies in Iran and is standardized. Ghazanfar Pour and his colleagues in their study reported Cronbach’s alpha for the questionnaire as 0.9, which is an acceptable number (14). The questionnaire was completed by women residents before and at the end of the intervention period for each of the subjects by individual interviews.…”

Section: Methodsmentioning

confidence: 97%

“…In this study, the percentage of observed parabasal cells in Pap smear samples was the criteria of the severity of vaginal atrophy, in a way that increased in the number of parabasal cells and decreased in superficial cells, which indicated more severity of atrophy (49). Because the aim was to determine the effect of three types of cream on the severity of vaginal atrophy and to compare the patient’s condition before and after using this cream, a collaborator pathologist, who was unaware of the study groups, classified and reported severe atrophy as follows based on the percentage of parabasal cells in LAM of patients (14). The antioxidant activity of royal jelly was evaluated by DPPH (2, 2-diphenyl-1-picrylhydrazyl) assay (15).…”

Section: Methodsmentioning

confidence: 99%

Comparison between vaginal royal jelly and vaginal estrogen effects on quality of life and vaginal atrophy in postmenopausal women: a clinical trial study

2016

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ObjectiveThis study was conducted to evaluate the therapeutic effects of vaginal royal jelly and vaginal estrogen on quality of life and vaginal atrophy in postmenopausal women.MethodsThis double-blind randomized controlled clinical trial was carried out at gynecology and obstetrics clinics of Hajar Hospital of Shahrekord University of Medical Sciences (Iran) from January 2013 to January 2014. The study was conducted on married postmenopausal women between 50 and 65 years old. Of 120 patients, 30 individuals were excluded based on the exclusion criteria, and 90 women were randomly distributed into three groups of 30 royal jelly vaginal cream 15%, vaginal Premarin, and placebo (lubricant), for three months. At the beginning and the end of the study, quality of life and vaginal cytology assay were evaluated. Data were analyzed by SPSS Version 11.ResultsVaginal cream of royal jelly is significantly more effective than vaginal cream of Premarin and lubricant in improvement of quality of life in postmenopausal women (p<0.05). Moreover, Pap smear results showed that vaginal atrophy in vaginal Premarin group was lower than the other groups (p<0.001), and there was no significant difference between lubricant and royal jelly groups (p=0.89).ConclusionAdministration of vaginal royal jelly was effective in quality-of-life improvement of postmenopausal women. Given to the various properties of royal jelly and its effectiveness on quality of life and vaginal atrophy in postmenopausal women, further studies are recommended for using =royal jelly in improving menopausal symptoms.Clinical trial registrationThe trial was registered at the Iranian Registry of Clinical Trials (http://www.irct.ir) with the IRCT code: 2014112220043n1.FundingShahrekord University of Medical Sciences supported this research (project no. 1440).

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“…MDA is a lipid peroxidation product, which has been used as a biomarker of lipid peroxidation for several decades. (36) A previous study found that JXR improved oxidative stress in insulin resistance rats. (37) Several studies have revealed that constituents in JXR including Fructus Ligustri Lucidi, Radix Astragali, Rhizoma Coptidis, can ameliorate oxidative stress and exhibit antioxidant activity.…”

Section: Discussionmentioning

confidence: 99%

Jiangtang Xiaozhi Recipe (降糖消脂方) prevents diabetic retinopathy in streptozotocin-induced diabetic rats

Zhou

et al. 2016

Chin. J. Integr. Med.

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Effects of royal jelly supplementation on glycemic control and oxidative stress factors in type 2 diabetic female: A randomized clinical trial

Abstract: On the basis of our findings, it seems that royal jelly supplementation may be beneficial in controlling diabetes outcomes. Further studies with larger sample size are warranted.

Cited by 63 publications

References 26 publications

Royal jelly protects male rats from heat stress‐induced reproductive failure

Royal jelly protects male rats from heat stress‐induced reproductive failure

Comparison between vaginal royal jelly and vaginal estrogen effects on quality of life and vaginal atrophy in postmenopausal women: a clinical trial study

Jiangtang Xiaozhi Recipe (降糖消脂方) prevents diabetic retinopathy in streptozotocin-induced diabetic rats

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