Effects of Roundup and glyphosate formulations on intracellular transport, microtubules and actin filaments in Xenopus laevis melanophores

Hedberg, Daniel; Wallin, Margareta

doi:10.1016/j.tiv.2009.12.020

Cited by 50 publications

(29 citation statements)

References 28 publications

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“…Tsui and Chu showed that Roundup ® or the surfactant used are more toxic than glyphosate alone in bacteria (Vibrio fischeri) and in different aquatic plant and animal species. Such a result has also been demonstrated in freshwater oligochaetes (Contardo-Jara et al, 2009), amphibians (Howe et al, 2004;Hedberg and Wallin, 2010) and mammals, including humans (Peixoto, 2005;Pieniążek et al, 2004).…”

Section: Introductionmentioning

confidence: 61%

“…In the blackworm, Lumbriculus variegatus, exposure to Roundup Ultra ® led to a significant increase in both soluble glutathione S-transferase (sGST) and superoxide dismutase (SOD); exposure to glyphosate led to an elevation of sGST but to a lesser extent (Contardo-Jara et al, 2009). In melanophores from Xenopus laevis, Hedberg and Wallin (2010) reported that Roundup ® formulations inhibit intracellular transport through the disassembly of the cytoskeleton, possibly by interfering with intracellular Ca 2+ -balance. According to Peixoto (2005), glyphosate alone did not impact the bioenergetics of isolated rat liver mitochondria, in contrast to Roundup formulation products.…”

Section: Comparison Of the Effects Of Glyphosate/ampa And Roundup ® Fmentioning

confidence: 99%

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Effects of glyphosate-based herbicides on embryo-larval development and metamorphosis in the Pacific oyster, Crassostrea gigas

Mottier¹,

Kientz-Bouchart²,

Serpentini³

et al. 2013

Aquatic Toxicology

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Section: Introductionmentioning

confidence: 61%

Section: Comparison Of the Effects Of Glyphosate/ampa And Roundup ® Fmentioning

confidence: 99%

Effects of glyphosate-based herbicides on embryo-larval development and metamorphosis in the Pacific oyster, Crassostrea gigas

Mottier¹,

Kientz-Bouchart²,

Serpentini³

et al. 2013

Aquatic Toxicology

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“…There is evidence that the bioaccumulation of glyphosate may be greater than predicted from the log K OW value alone and the bioconcentration factor (BCF) is increased for glyphosate in the presence of POEA in the aquatic environment (Contardo-Jara et al, 2009). It has been suggested that the same function POEA provides, by enhancing glyphosate transport into plant cells, also facilitates increased permeability in animal cells (Hedberg and Wallin, 2010). The potential for bioaccumulation of glyphosate has also been observed in terrestrial snails (Helix aspersa) fed a diet contaminated with glyphosate (Druart et al, 2011), water hyacinth (Eichhornia crassipes) exposed to pure glyphosate, and also in tissue of carp (Cyprinus carpio) and tilapia (Oreochromis mossambicus) that were exposed to environmentally relevant concentrations (Wang et al, 1994).…”

Section: Exposure To Glyphosate and Metabolites In Aquatic Environmentmentioning

confidence: 99%

Impact of glyphosate and glyphosate‐based herbicides on the freshwater environment

Annett

Habibi

Hontela

2014

J of Applied Toxicology

443

243

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Glyphosate [N-(phosphonomethyl) glycine] is a broad spectrum, post emergent herbicide and is among the most widely used agricultural chemicals globally. Initially developed to control the growth of weed species in agriculture, this herbicide also plays an important role in both modern silviculture and domestic weed control. The creation of glyphosate tolerant crop species has significantly increased the demand and use of this herbicide and has also increased the risk of exposure to non-target species. Commercially available glyphosate-based herbicides are comprised of multiple, often proprietary, constituents, each with a unique level of toxicity. Surfactants used to increase herbicide efficacy have been identified in some studies as the chemicals responsible for toxicity of glyphosate-based herbicides to non-target species, yet they are often difficult to chemically identify. Most glyphosate-based herbicides are not approved for use in the aquatic environment; however, measurable quantities of the active ingredient and surfactants are detected in surface waters, giving them the potential to alter the physiology of aquatic organisms. Acute toxicity is highly species dependant across all taxa, with toxicity depending on the timing, magnitude, and route of exposure. The toxicity of glyphosate to amphibians has been a major focus of recent research, which has suggested increased sensitivity compared with other vertebrates due to their life history traits and reliance on both the aquatic and terrestrial environments. This review is designed to update previous reviews of glyphosate-based herbicide toxicity, with a focus on recent studies of the aquatic toxicity of this class of chemicals.

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“…Hedberg and Wallin (2010) showed that pesticides inhibit intracellular transport of the melanopores of the fish, Xenopus laevis resulting a change in body colouration. Similarly, the change of the body colouration of the tilapia in the present experiment may be due to the toxicity effect of Trebon ® .…”

Section: Discussionmentioning

confidence: 99%

Toxic effects of Trebon®, a synthetic pyrethroid based insecticide formulation, on Oreochromis mossambicus (Family: Cichlidae)

Chandrasekara

2016

Sri Lanka J. Aquat.

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Trebon ® (active ingredient: Etofenprox) is a recently developed potential pyrethroid insecticide formulation and reported to bring about adverse effects to non-targeted organisms in agricultural fields and associated habitats. The toxic effects of Trebon ® on fingerlings of tilapia (Oreochromis mossambicus) were studied in the present investigation following standard laboratory experimentation procedures.Results revealed that the 24-hr and 96-hr LC50 s of Trebon ® were 0.0657 mg L -1 and 0.0087 mg L -1 respectively which are nearly 23 times and 172 times below its recommended field dose which is 1.5 mg L -1 . It therefore appears that Trebon ® brings about mortality to tilapia fingerlings at concentrations that are milder than the field dose within a short period of exposure. Gill hyperplasia, deformation and telangiectasis of secondary gill lamella, mucosal cell proliferation, lamella disorganization and fusion were observed in the insecticide exposed test fishes. The liver tissues were also damaged with intracellular vacuolation, aggregation of melanomacrophages, blood congestion and focal necrosis. The severity of these damages increased with the level of dosage and the exposure period. The fingerlings suffered respiratory distress while the body coloration gradually changed into a pale hue upon exposure to Trebon ® .

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Effects of Roundup and glyphosate formulations on intracellular transport, microtubules and actin filaments in Xenopus laevis melanophores

Cited by 50 publications

References 28 publications

Effects of glyphosate-based herbicides on embryo-larval development and metamorphosis in the Pacific oyster, Crassostrea gigas

Effects of glyphosate-based herbicides on embryo-larval development and metamorphosis in the Pacific oyster, Crassostrea gigas

Impact of glyphosate and glyphosate‐based herbicides on the freshwater environment

Toxic effects of Trebon®, a synthetic pyrethroid based insecticide formulation, on Oreochromis mossambicus (Family: Cichlidae)

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